ID A0A126ZGR9_9BURK Unreviewed; 1160 AA.
AC A0A126ZGR9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=AX767_18725 {ECO:0000313|EMBL:AMM26156.1};
OS Variovorax sp. PAMC 28711.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=1795631 {ECO:0000313|EMBL:AMM26156.1, ECO:0000313|Proteomes:UP000070169};
RN [1] {ECO:0000313|EMBL:AMM26156.1, ECO:0000313|Proteomes:UP000070169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 28711 {ECO:0000313|EMBL:AMM26156.1,
RC ECO:0000313|Proteomes:UP000070169};
RA Park H.;
RT "Complete genome of Variovorax sp.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP014517; AMM26156.1; -; Genomic_DNA.
DR RefSeq; WP_068632695.1; NZ_CP014517.1.
DR AlphaFoldDB; A0A126ZGR9; -.
DR STRING; 1795631.AX767_18725; -.
DR KEGG; vaa:AX767_18725; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000070169; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000070169}.
FT DOMAIN 623..784
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 805..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1160 AA; 129430 MW; 4153500B8EADE392 CRC64;
MDLPPLTAGK RFTLPRPPLS ADALLLSQLA TREKAMGHAT AVFTADANDA QRLIDEIAFF
APELRCALFP DWETLPYDSF SPHQDLISER LATLWRISQK EADVVLVPAT TALYRLAPPS
FLAGYTFHFK TKQKLEESKL KAQLTLAGYS HVTQVVSPGE YAVRGGLIDL FPMGSLVPFR
VDLFDDEIDS IRTFDPDTQR SLYPVPEVRL LPGREFPMDD DARARFRSRW REMLDGDPTK
SRIYKDMGNG VATAGIEYYL PLFFEETATV FDYLGTETTV VLHGDLEPAF QHFWQDTGER
YRLVRGDPER PALPPETLFL NAEQFYQRAK PLAQLAIRGD VATDTPYAEF DKLPPFAVVR
GADDPLTGLK AHIRATPHRV LVIAESNGRR ESLLDFLRAS GVSPPAFDSL AEFEASPDEK
IGIATAALAS GFAWREQGID FVTETELFAT APTTRRRNKK QEQVSDVEAL IKDLSELNVG
DPVVHSAHGI GRYRGLIHMD LGQGKDAEGK PLLQEMLHLE YADKATLYVP VSQLHLISRY
TGVSADEAPL HKLGSGQWEK AKRKAAEQVR DSAAELLNIY ARRALRQGHA FRYSAADYEV
FANDFGFEET ADQKAAIHAV IQDMISPQPM DRLVCGDVGF GKTEVALRAA FIAITGGKQV
ALLAPTTLLA EQHYQTLVDR FAKWPVKVAE VSRFRSGKEV STALKGLADG NVDIVVGTHK
LLSESTKFAN LGLLIIDEEH RFGVRHKEQM KALRAEVDVL TLTATPIPRT LGMALEGLRD
LSVIATAPQR RLAIKTFVRN EGTGVIREAV LRELKRGGQV YFLHNEVETI ENRRQKLEEI
LPEARIAVAH GQMPERELER VMRDFVAQRY NLLLCSTIIE TGIDVPTANT IVMSRADKFG
LAQLHQLRGR VGRSHHQAYA YLMVPDTEGL TKQAAQRLDA IQQMEELGSG FYLAMHDLEI
RGAGEVLGEN QSGNMMEIGF QLYNEMLSEA VRSLKEGKEP DLLSPLHVTT EINLHAPALL
PDNYCGDVHL RLSFYKKLAT AKTSDQIDTL LEEIVDRFGK LPPQAQTLID THRLRVLARP
YGVVKVDAAP GVIHITFKKD PPVDSMAIIH LIQKNKHIKL AGNEKLRIER ELKEPKERAQ
MVRDVLRSLG QPKVQEPVAA
//
