ID A0A133Q8E2_STALU Unreviewed; 142 AA.
AC A0A133Q8E2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Na(+)/H(+) antiporter subunit B1 {ECO:0000256|ARBA:ARBA00018332, ECO:0000256|RuleBase:RU368067};
DE AltName: Full=Mnh complex subunit B1 {ECO:0000256|ARBA:ARBA00031664, ECO:0000256|RuleBase:RU368067};
GN ORFNames=EQ812_03800 {ECO:0000313|EMBL:TBW72977.1}, HMPREF3225_00767
GN {ECO:0000313|EMBL:KXA39136.1};
OS Staphylococcus lugdunensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=28035 {ECO:0000313|EMBL:KXA39136.1, ECO:0000313|Proteomes:UP000070063};
RN [1] {ECO:0000313|EMBL:KXA39136.1, ECO:0000313|Proteomes:UP000070063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJR7738 {ECO:0000313|EMBL:KXA39136.1,
RC ECO:0000313|Proteomes:UP000070063};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TBW72977.1, ECO:0000313|Proteomes:UP000293637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E7 {ECO:0000313|EMBL:TBW72977.1,
RC ECO:0000313|Proteomes:UP000293637};
RA Williams M.R.;
RT "Quorum sensing between bacterial species on the skin protects against
RT epidermal injury in atopic dermatitis.";
RL Sci. Transl. Med. 0:0-0(2019).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000256|RuleBase:RU368067}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000256|ARBA:ARBA00011568, ECO:0000256|RuleBase:RU368067}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU368067}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368067}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B
CC family. {ECO:0000256|ARBA:ARBA00009425, ECO:0000256|RuleBase:RU368067}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXA39136.1}.
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DR EMBL; LRQI01000029; KXA39136.1; -; Genomic_DNA.
DR EMBL; SCHB01000002; TBW72977.1; -; Genomic_DNA.
DR RefSeq; WP_002459551.1; NZ_SCHB01000002.1.
DR AlphaFoldDB; A0A133Q8E2; -.
DR STRING; 28035.B6N84_09525; -.
DR GeneID; 58090187; -.
DR PATRIC; fig|28035.7.peg.778; -.
DR eggNOG; COG2111; Bacteria.
DR OMA; HPGFLMP; -.
DR Proteomes; UP000070063; Unassembled WGS sequence.
DR Proteomes; UP000293637; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR InterPro; IPR005281; CPA3_sub_B.
DR InterPro; IPR007182; MnhB.
DR NCBIfam; TIGR00943; 2a6301s02; 1.
DR PANTHER; PTHR33932; NA(+)/H(+) ANTIPORTER SUBUNIT B; 1.
DR PANTHER; PTHR33932:SF4; NA(+)_H(+) ANTIPORTER SUBUNIT B1; 1.
DR Pfam; PF04039; MnhB; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU368067};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU368067};
KW Hydrogen ion transport {ECO:0000256|RuleBase:RU368067};
KW Ion transport {ECO:0000256|RuleBase:RU368067};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368067};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368067};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368067}; Transport {ECO:0000256|RuleBase:RU368067}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368067"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368067"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368067"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368067"
FT DOMAIN 10..133
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 142 AA; 15660 MW; 3A36EE1377267F6E CRC64;
MNRQKNNLML QYAAVIIALL ISLFAVTLFL AGHYTPGGGF VGGLLISSAL VIITIAFDIK
TMRRIFPWDF KILIGIGLVF CVTTPIASWL YGENFFTHTE FNVPLPLLAP MHMNTPMFFD
FGVLCAVVGT VMTIIITIGE ND
//
