ID A0A133S7L2_9FIRM Unreviewed; 290 AA.
AC A0A133S7L2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Phosphogluconate dehydrogenase, NAD binding domain protein {ECO:0000313|EMBL:KXA65680.1};
GN ORFNames=HMPREF3201_02475 {ECO:0000313|EMBL:KXA65680.1};
OS Megasphaera sp. MJR8396C.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1603888 {ECO:0000313|EMBL:KXA65680.1, ECO:0000313|Proteomes:UP000070314};
RN [1] {ECO:0000313|EMBL:KXA65680.1, ECO:0000313|Proteomes:UP000070314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJR9396C {ECO:0000313|EMBL:KXA65680.1,
RC ECO:0000313|Proteomes:UP000070314};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXA65680.1}.
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DR EMBL; LRVC01000125; KXA65680.1; -; Genomic_DNA.
DR RefSeq; WP_062413154.1; NZ_KQ958212.1.
DR AlphaFoldDB; A0A133S7L2; -.
DR STRING; 1603888.HMPREF3201_02475; -.
DR PATRIC; fig|1603888.3.peg.2391; -.
DR Proteomes; UP000070314; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 5..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30397 MW; 6879D8F1A7CE8DD2 CRC64;
MNTTTIGFIG TGVMGTGMIR NLLKAGFPVN IYTRTKSKAD ALISEGCQWF ESPSAVAAAS
DVVISIVGYP KDVEEVYLGD NGILKGKKGG TVIDMTTSSP SLAKEIYHKA KSLGIDALDA
PVSGGDVGAK NGTLAIMVGG DEDAFKAMNA VFSAMGKTLT YFGPAGSGQY AKMSNQIAIA
SNMMGVCEAI AYAQKSGLDP EKVIATLSSG AAGSWSLANL APRMVKGDTA PGFYIKHFIK
DMRIALESAA EMKLDLPGLT LAKKLYDKLA ADGMEDCGTQ ALFQWYANQK
//
