ID A0A135LD63_PENPA Unreviewed; 950 AA.
AC A0A135LD63;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PGRI_036470 {ECO:0000313|EMBL:KXG46901.1};
OS Penicillium patulum (Penicillium griseofulvum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=5078 {ECO:0000313|EMBL:KXG46901.1, ECO:0000313|Proteomes:UP000070168};
RN [1] {ECO:0000313|EMBL:KXG46901.1, ECO:0000313|Proteomes:UP000070168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG3 {ECO:0000313|EMBL:KXG46901.1,
RC ECO:0000313|Proteomes:UP000070168};
RX PubMed=26729047; DOI=10.1186/s12864-015-2347-x;
RA Banani H., Marcet-Houben M., Ballester A.R., Abbruscato P.,
RA Gonzalez-Candelas L., Gabaldon T., Spadaro D.;
RT "Genome sequencing and secondary metabolism of the postharvest pathogen
RT Penicillium griseofulvum.";
RL BMC Genomics 17:19-19(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXG46901.1}.
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DR EMBL; LHQR01000067; KXG46901.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A135LD63; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000070168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..187
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 210..376
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 387..670
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 825..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 107024 MW; 72908D557D426120 CRC64;
MDIHHLSLHA RTNGADTFLE LIANPFRSAF TVTAIWASLG TSIGVTILLA LVFSLVRPRH
SLVYAPKVKH ADLKHTPPPV GKGIFAWVKP VINTREPQLI ETVGLDAALF LRFTKMCRNI
FICLSIIGCL VMIPVNITQS RSTTDHSASS AFNMMTPLNI DNPTAIWSQV VCAWAFDLIV
VYFLWRNYRV VRKLRRQYFQ SSEYQRSLHA RTLMITDIPP NSRADEGILR LTDQVNPTAA
LPRAAIGRNV RDLPRIIKEH EEAVRQLESV LAKYLKNPDR LPAKRPTLRP PRKQRNQLGS
GKVDAIDYLT VRIRVLEEEI KHGRASIDRR NAMPYGFASW DNIEHAHAVA WNARRKHPEG
ITVDLAPRPS DIIWENLPLS KSARKWKRLV NFIWVTCLTL VWIVPNGLIA IFLSNLSNLG
LVWPAFQTSL SGNPHVWAAV QGIASPALTS LVYLALPIIF RRLSIQGGSK TKTSRERHVL
GHLYAFFVFN NLIVFSLFSA AWYFVSFVID KTNNHEDAWQ AILESRMYAK LVSALCTVSP
FWVTYLLQRN LGAAIDLVQL VTMIWVWFAK TFLSPTPRQA IEWTAPPPFD YASYYNYFLF
YATVAFCFAT LQPIVLPVTA LYFGVDALLK KYLLMYVFIT KNESGGAFWR VLFNRLIFAT
ILANVIIALV AKSSGTWTMV FCVVPLPFLM LGFKFYCMKT FDSDCEYYNR ANLSDAEALG
VSKSDKKASD RLNSKFGHPA LYKPLLTPMV HAKAAAALKD IYQGRMDQGD TSEYSDIAMN
PMLASQPGKS AEPSPFEVVP ENHLDFSYYK DRADFRDEFG GGIYGRPEDL MTERSHTPRS
TLRGEWSPGS SRASSPAPSL PSMPPLSMHN GYEPPDPTGL VHPAFRVPLS RGDSGYPIDE
AESRLLTHAQ TPGQADIANP LDRWRTRGYG PVGQDDEPAY TSYDAYRPPR
//
