ID   A0A135LTZ7_PENPA        Unreviewed;       790 AA.
AC   A0A135LTZ7;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Peptidase M3A/M3B {ECO:0000313|EMBL:KXG52432.1};
GN   ORFNames=PGRI_087160 {ECO:0000313|EMBL:KXG52432.1};
OS   Penicillium patulum (Penicillium griseofulvum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=5078 {ECO:0000313|EMBL:KXG52432.1, ECO:0000313|Proteomes:UP000070168};
RN   [1] {ECO:0000313|EMBL:KXG52432.1, ECO:0000313|Proteomes:UP000070168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG3 {ECO:0000313|EMBL:KXG52432.1,
RC   ECO:0000313|Proteomes:UP000070168};
RX   PubMed=26729047; DOI=10.1186/s12864-015-2347-x;
RA   Banani H., Marcet-Houben M., Ballester A.R., Abbruscato P.,
RA   Gonzalez-Candelas L., Gabaldon T., Spadaro D.;
RT   "Genome sequencing and secondary metabolism of the postharvest pathogen
RT   Penicillium griseofulvum.";
RL   BMC Genomics 17:19-19(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXG52432.1}.
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DR   EMBL; LHQR01000026; KXG52432.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A135LTZ7; -.
DR   STRING; 5078.A0A135LTZ7; -.
DR   OMA; KNFQSAM; -.
DR   OrthoDB; 735202at2759; -.
DR   Proteomes; UP000070168; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070168};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          296..788
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   790 AA;  89559 MW;  ECEBCFCDEB3CE5DA CRC64;
     MSFGSPDKFI SPSVPSFPFK RRIPPIITLT SRVHLVAALL AILIVAPFLR IPARLSSALG
     HLRTNVSIRS LTTSSMAPAH LRKPPQAPPI FTATPQSVVA DAERLIKSSR AIQDKVVAEI
     KPEAATFDNV VRPLAQDDNE MGLESHILGF YQAVSTDSKL RDASSKAEEL MDEFFIEAVM
     REDVFTLFDA VLRRNESLDP ESRRLLEKEH KDFVRNGLGL PAGPQRLRFK EIKKRLSQLS
     IEFQKNLNEE NGGIWFTPEQ LAGVPKDVLD GLKKGEGENA GKLWLSFKYP DLFPTMKYAI
     DPEIRRQVMI ANENKCNQNV PLFRETIILR DEAARLIGYP NHAAFRIEDK MAKTPETVNK
     FLGDLRDRLT AGGKKETQKL LDLKNATDPK ADGRYYLWDH RFYDRLMLEK DYSLDQQLIA
     EWFPLQTTIE GMLKIFEELF GLEFVEIVGE DRAAIAPTGQ GNDIVWHEDV QVYSVWNDEG
     EGSGFVGYLY LDLFPREGKY GHAANFNLQP GFIGKDGNRR FPATALVCNF TKPQPKKPSL
     LKHDEVVTLF HELGHGIHDL VSRTIYSRFH GTSTVRDFVE APSQMLENWC WTPSQLRSLS
     RHYSTLSPEY LASWQEAQDG EKAKTQPSER IPDDVIENLI RTKHVNDSLF NLRQLHFGIF
     DMTVHEPKTH ADIEALPLSA TYNRLRQEIT QMDGPEALGA GSEWGHGEAT FGHLIGGYDA
     GYYGYLSSQV YSTDMFYTVF KDDPMNKAAG RRYRYQVLEK GGSQDEMKTL TEFLGREPQT
     DAFYKDLGLA
//