ID   A0A135VE26_9ARCH        Unreviewed;       373 AA.
AC   A0A135VE26;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AM325_10730 {ECO:0000313|EMBL:KXH70916.1};
OS   Candidatus Thorarchaeota archaeon SMTZ1-45.
OC   Archaea; Asgard group; Candidatus Thorarchaeota.
OX   NCBI_TaxID=1706444 {ECO:0000313|EMBL:KXH70916.1, ECO:0000313|Proteomes:UP000070149};
RN   [1] {ECO:0000313|EMBL:KXH70916.1, ECO:0000313|Proteomes:UP000070149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMTZ1-45 {ECO:0000313|EMBL:KXH70916.1};
RX   PubMed=26824177;
RA   Seitz K.W., Lazar C.S., Hinrichs K.U., Teske A.P., Baker B.J.;
RT   "Genomic reconstruction of a novel, deeply branched sediment archaeal
RT   phylum with pathways for acetogenesis and sulfur reduction.";
RL   ISME J. 0:0-0(2016).
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXH70916.1}.
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DR   EMBL; LRSL01000107; KXH70916.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A135VE26; -.
DR   STRING; 1706444.AM325_10730; -.
DR   Proteomes; UP000070149; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          4..183
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          186..281
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          299..365
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   373 AA;  40897 MW;  BEB2771C420CC666 CRC64;
     MVNKIAVIGA GLMGAGIAYV SAWNGFNVSI VDTKEEFIEK GMERIRTDVM TGIDKGKISM
     SDAEGLMSRL SPTINLEEAV KEADLVIEAI FENMDVKKEI FAKIDAAAPA HAILATNTSS
     LSIDELATAT KRPDKFIGMH YFSPVPAMKL LELVIGEKTS DETIAAVESV GKTQGKKTVR
     AKNSPGFIVN RILNPALREG ILMLERGEAT KEEIDTAMVS IGKAPAGPFS LGDFVGLDIA
     YNAMSTLYRE IGDCFKPPET LKNLVESGNF GMKTKKGFYS YGKEEEEPEP PKGADPQWIV
     ERINIPAIRE AMILVDDDIA NKEDIDMAMK LGASWPMGPF EMLDHFGIDK VRDFIKKLHE
     EFGDCYSIPK YLG
//