ID A0A136ILI9_9PEZI Unreviewed; 1438 AA.
AC A0A136ILI9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Dicer-like protein 1 {ECO:0000256|ARBA:ARBA00020797};
GN ORFNames=Micbo1qcDRAFT_127314 {ECO:0000313|EMBL:KXJ85785.1};
OS Microdochium bolleyi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ85785.1, ECO:0000313|Proteomes:UP000070501};
RN [1] {ECO:0000313|Proteomes:UP000070501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG DOE Joint Genome Institute;
RA David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA Barry K., Grigoriev I.V.;
RT "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT beachgrass.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; KQ964274; KXJ85785.1; -; Genomic_DNA.
DR STRING; 196109.A0A136ILI9; -.
DR InParanoid; A0A136ILI9; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000070501; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF62; DICER-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 2.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070501};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 18..199
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 337..499
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 534..624
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 951..1094
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1145..1308
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
SQ SEQUENCE 1438 AA; 162412 MW; 2AC8110065C00078 CRC64;
MEESRRITTS PREYQVELFE KAKQQNTIVV LDTGSGKTLI AALLLHHTID QEYEDRKQGH
PNRISVFLVD KIALAKQQHR VLKQNLDCNI ACFAGDAGNV PRTQEFWQKQ LDENMVIVCV
GAVLQKCLHR SYISMEQINL LVFDEAHHAK REHPYARIIT DFYASSKALR LPRIFGMTAS
PVDAKTDFDQ AASELEGLLH SKIATVGDPS LLKSSICKAE EHTVEYNIPF DPFDTALSQR
LQPLLGSIRA ADKLFVYAKL CTAELGPWCA DHLWRMALDE NEDGLGKLKI SLEGSVHDVA
ALNDAMEAAH AAQDIVVAHQ FAELSSSPLL LTNKVHKLVE LLRHTFRPGR DKCVIFVSKR
LTASLLVEVL QNQAVSLPGI EAARMIGTGR SGWGEPSMTI RDQMRTIQRF LDGCLNVLVA
TSVAEEGLDI PDCNMVIRFD PCNTMIQYIQ SRGRARQARS RLYYFVQLGH SGHRALLLDI
QEQENQMRQF CATRPEDRRV DAAGASIESL LSKRAKERVF TIPSTGAKLT YRVSLELLAD
FAHSLEDKDG CKVSPTYIVR PIPGGFKAEV TLPEGSPVTS MAGIRETSKQ LAKCAAAFDM
CKELRRKKCL DEWLRSVFTK RLPAMRSAKL ALTSTKVAEY QMQIKPAIWC VLGLPEEVYL
TVVRLKSREP LQRRSVPLAF MTRTPMPKIG DIPLFFAGKR NAALELLPLL QPMKLGKEQV
RILTIFTLRI FRDIFSKKYA VEPDKLPYYL APMSQQCSDL KDIDPRSLLE SLDWDNLTYV
ESTDFVATNS LTHDQLCDRY VVDPHNGARK FYTNRVVTHL RGSDPQLSAA PRSARIIRAT
RDSPDDIWNY SVGLWSNARS KIQRNEDLPV IEAEHISIRR NLLDSTEEIE PDATCYLVFQ
TLEISALKPA IVATAYTLPA MIFRLESALI ALEACAASGL GAIAPPLALP ALTKNSDNTD
EHDQEQVNFQ QGMGENYERL EFLGDSFLKM STTIALYARE PDTSEFFQHV NRMVLINNKN
LYETGLKFGI PNKIRSRAFN RRLWYPEGLM LLQGKKNDSI LGSREAKKTS HTLAAKTIAD
VCEALIGAAY LTAREHGNMD LAVLAVTKFV NAKEHTMEKW EDFYPTYSIP HWQKVKPSAA
QETLADKLKE KLGHRFESPT LARCAFTHPS YSSLFEGVPS YQQLEFLGDA LLDMVCVDYL
FQKYPRADPQ WLTEHKMAMV SNQFLAYLCV SLDLHGHMQT THMELKQQIM RYADTVNLAR
EDAEAKAEAV GLARHEHAKD FWMQLHKPPK ALSDIVEAYI GAIFVDSEFD FSQVQKFFET
HVLPHFVDMQ LYDTFASKQP ITLLINTLQE RFHCQRARIM SRTVPKVGRG ASVMDDEGVC
FIMIHGAKVQ DGCAESERYA RIKVAKELNK TLEDMEIREF RRKYACDCKL PEGASVGF
//
