ID A0A136NDB5_9BACT Unreviewed; 484 AA.
AC A0A136NDB5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000256|ARBA:ARBA00019562};
DE EC=1.1.1.42 {ECO:0000256|ARBA:ARBA00013013};
DE AltName: Full=IDP {ECO:0000256|ARBA:ARBA00029765};
DE AltName: Full=NADP(+)-specific ICDH {ECO:0000256|ARBA:ARBA00029990};
DE AltName: Full=Oxalosuccinate decarboxylase {ECO:0000256|ARBA:ARBA00031098};
GN Name=leuB {ECO:0000313|EMBL:KXK44160.1};
GN ORFNames=UZ05_CHB002002706 {ECO:0000313|EMBL:KXK44160.1};
OS Chlorobi bacterium OLB5.
OC Bacteria; Chlorobiota.
OX NCBI_TaxID=1617412 {ECO:0000313|EMBL:KXK44160.1, ECO:0000313|Proteomes:UP000070057};
RN [1] {ECO:0000313|EMBL:KXK44160.1, ECO:0000313|Proteomes:UP000070057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLB5 {ECO:0000313|EMBL:KXK44160.1};
RA Speth D.R., In T Zandt M., Guerrero Cruz S., Dutilh B.E., Jetten M.S.;
RT "Genome based microbial ecology of anammox granules in a full-scale
RT wastewater treatment system.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH;
CC Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42;
CC Evidence={ECO:0000256|ARBA:ARBA00023554};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXK44160.1}.
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DR EMBL; LLZO01000315; KXK44160.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A136NDB5; -.
DR PATRIC; fig|1617412.3.peg.2837; -.
DR Proteomes; UP000070057; Unassembled WGS sequence.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006097; P:glyoxylate cycle; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.30.70.1570; -; 1.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR014273; Isocitrate_DH_bac-typ.
DR InterPro; IPR040978; Isocitrate_DH_TT1725_C.
DR InterPro; IPR046997; Isocitrate_DH_TT1725_C_sf.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR NCBIfam; TIGR02924; ICDH_alpha; 1.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF43; ISOCITRATE DEHYDROGENASE [NADP]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR Pfam; PF18324; Isocitrate_DH_C_bact; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 6..337
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 484 AA; 53666 MW; 9BB8F719225A0857 CRC64;
MSENTPITVA YGDGIGPEIM QATLDVILAA GAKLDIEVIE IGEKVYSRGN TAGIEPSAWD
SLLRTRVFLK APITTPQGGG FKSLNVTTRK TLGLYANIRP CYSYYPFVET KHPVMDVVIM
RENEEDTYAG IEYRHTDQVT QCLKIISEPG SEKIIRYAFE YARANKRKKV TCFVKDNIMK
ITDGLFHKIF DKIGEEFPDL EKETWIVDIG AAKLATSPEQ FDVIVMENLY GDILSDVTAQ
MTGSVGLAGS ANIGDKCAMF EAIHGSAPRR AGQNSANPSG LLLGAVMMLA HIKQSDVAQK
VHNAWLKTIE DGIHTYDIFR EGTSKEKVGT KEFAQAVIAR LGQKPAKLKD VTYNDFEVKS
YDHYDYKKIK KAKKETVGCD IYLHWNEGSA NELGEKLSSL AVSGLKLVMI SNRGVKVYPH
GNAETFCVDH WRCRFQSVNE GESVNHSKII EQLNTLQNAG YDFIKTENLC TFDGVPGFSL
AQGQ
//