ID A0A136PPX2_9ACTN Unreviewed; 1973 AA.
AC A0A136PPX2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KXK60529.1};
GN ORFNames=AWW66_18400 {ECO:0000313|EMBL:KXK60529.1};
OS Micromonospora rosaria.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=47874 {ECO:0000313|EMBL:KXK60529.1, ECO:0000313|Proteomes:UP000070620};
RN [1] {ECO:0000313|EMBL:KXK60529.1, ECO:0000313|Proteomes:UP000070620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 803 {ECO:0000313|EMBL:KXK60529.1,
RC ECO:0000313|Proteomes:UP000070620};
RA Yang H., He X., Zhu D.;
RT "Whole genome sequence and analysis of Micromonospora rosaria DSM 803,
RT which can produce antibacterial substance rosamicin.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXK60529.1}.
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DR EMBL; LRQV01000068; KXK60529.1; -; Genomic_DNA.
DR RefSeq; WP_067367776.1; NZ_LRQV01000068.1.
DR OrthoDB; 3406074at2; -.
DR Proteomes; UP000070620; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000070620};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..443
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1350..1424
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 904..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1973 AA; 218467 MW; E44FB069A1B959D5 CRC64;
MPESRATKRR ETGLEIAVVG MAGRFPQAED IDQFWANLVE GVDAISRFTD DELLGVGVAK
AALDDERYVR AKGVFPNIEY FDAEFFNYAP ADATLLDPQV RALHEEVFHA LEDAGYSAEG
RPEVIGLFLG ATNNLPWETH TLTRHILESG MTFTGMQLND KDFAATRIAY ALDLKGPAFT
LHTACSTSLV AIDMACRNLW TGSCQIALAG GSGLTLPHKN GYRYQENMIH SPDGHCRPFD
KDAAGTVEGN GVGVVVLKRL ETALRDGDHV YAVIKGSAVN NDGNRKVGYT APSIEGQAEV
IRKAYRVANV PTAEVSYVET HGTGTSLGDP IEVEALRKAF GTGEPGATGL GSLKASIGHL
DTGAGVASLI KVCKILQHRT VPRSLHFKEL NPNVDLDGSP FYVVAEQQEL RPKRSKTDEV
LPLRAGVSSF GIGGTNAHVV LEEAPEARPA SSTGRTYNTF VVSASSADAV GRIKRNFVDY
LAAHPDLDGS DLAWTLQNRQ RRLAHRYAVE FGDVAQLRER LQESLDADEP SAQVHKNARR
DAYFLFSGLG AQHLRMARGL YETEPDFRAH LDECFTISAA QGHEVPREVF FGDSAEAERQ
LNNIGTTQIL LFMLETSMAR TLIGWGLKPK GMIGHSTGEL AAAYVAGVFS LADGIRLVQA
RGSLMDTTVE GALTSVRAPE DVVRGMLTDE SAIAAVNGPE DCTVSGTPRA VAEVERQCAE
REIKFSHIEA DHAYHSQYMD SMLGRFREVL DQVTLHQPKI PYLSNVTGTW ITAAQATDRE
YYCSHARETV RFAAGVEAIL ERGGTLFVEV GPGKSLSSFV RAIGRDAEVT TVNMLRHRME
EVSDEEHLAR AVKKLWENGV SLDWKAFHKG RHPRKVTLPL YPFEKVEYPV DIEQFQRLVE
GQTDAGPRAA TVQPTRQAVT GTEATTGPVP ASRLAWAPSM RPSSTGKEQP KVLIALTDDR
RGLKRVLDGV AHWRTLYVSF GPQYRFDRLS GAVVRPGHDD DLRRLLDDLE RHALAGDTVV
VDRTDHPSLV TTLRGLCAAI PDMRERCVKD VVVLDTGDLL GAHGDVVPLL IGLNHEHPTF
RVRALRCDAS LDDRAGRAAW REHLQTELEA HRPDDVAVSY ERGRRLVPRL VPLDGAVAAA
GRATRTALLA RRRDVENVVR DLAGANPART VEILPFDLGS DPGGTRVGVV DERITVLPVV
TGSTWEELAG TLSGGLRALP AVDEVVLWDT PSRDGATDGP DQRRLLGLLT EVGREQRIPC
YVLSRPGLDR DGWDRHVTTW FADNERAAAE AGITRLYSFA DLREADRSVL DLLPRMRDAG
IRTAYHGVDL LRAQAAAKLV DVEVESGRAD ERQAIAAVIE REVRTLLGFS EIDGRADIFD
IGLDSVKLVQ FTNALDRNGY KVLAKEVYNH PTIAGLAAFI ERTVTRGGSE DMSFDSLAVL
LEQRLGAPCV FREVKSGRDE DTLVVLAVAG LDEALKKRVV REFTELRVPT EFVPHYVVAG
GPDDIGMGLD FEALRASAGL PSYPGGYAAV FDEIDRRQEE LRRSIGAQPV KWTYPISAMQ
KQHFATESRL QLYLIQLREL VDLDVLQQAL CDVIGRHGLM RSFLTRSFGR FRWKEFEAPE
VIALPRLDMS GLEPHEQEEL RAELVKREWS MDFKVVDKPM YQVVLITYND RSHDLLFQFD
HSIFDAASGQ LFRGDLLKRY EELMAGTGRA MPIAKSYRHL QDQIAKGPVD ITSDELIEKF
DLVEYVRYAK TIQERSARFA NSPIRDVRYS VELDRLRNAD GTEPDLFYLV VHLYARVVSR
LLGIDKVALI TLLQSRVFED KDYSEVMGMV LGSLPVLVPA ERDTMRDLDG IITDKVRMMN
KNNVSFLNLV QNVRSIVKHR KVLSVMGKTL RPTCLLNFVG NVEDEYDAIW DMTLAQLTDD
QAKLDYADCY CVSKVGNGRL DLLLLSKWVE DPHELIRILD DEVEYLTSRV SAG
//
