ID A0A137P4S9_CONC2 Unreviewed; 486 AA.
AC A0A137P4S9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Metallo-dependent phosphatase {ECO:0000313|EMBL:KXN70006.1};
DE Flags: Fragment;
GN ORFNames=CONCODRAFT_27922 {ECO:0000313|EMBL:KXN70006.1};
OS Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638)
OS (Delacroixia coronata).
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Entomophthoromycetes; Entomophthorales;
OC Ancylistaceae; Conidiobolus.
OX NCBI_TaxID=796925 {ECO:0000313|EMBL:KXN70006.1, ECO:0000313|Proteomes:UP000070444};
RN [1] {ECO:0000313|EMBL:KXN70006.1, ECO:0000313|Proteomes:UP000070444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 28638 {ECO:0000313|EMBL:KXN70006.1,
RC ECO:0000313|Proteomes:UP000070444};
RX PubMed=25977457; DOI=10.1093/gbe/evv090;
RA Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA Spatafora J.W., Berbee M.L.;
RT "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT Walls of Algal Ancestors of Land Plants.";
RL Genome Biol. Evol. 7:1590-1601(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|RuleBase:RU003447}.
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DR EMBL; KQ964515; KXN70006.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A137P4S9; -.
DR STRING; 796925.A0A137P4S9; -.
DR EnsemblFungi; KXN70006; KXN70006; CONCODRAFT_27922.
DR OMA; NHTGHTN; -.
DR OrthoDB; 169704at2759; -.
DR Proteomes; UP000070444; Unassembled WGS sequence.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IEA:EnsemblFungi.
DR GO; GO:0030870; C:Mre11 complex; IEA:EnsemblFungi.
DR GO; GO:0035861; C:site of double-strand break; IEA:EnsemblFungi.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0004017; F:adenylate kinase activity; IEA:EnsemblFungi.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:EnsemblFungi.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IEA:EnsemblFungi.
DR GO; GO:0030145; F:manganese ion binding; IEA:EnsemblFungi.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:EnsemblFungi.
DR GO; GO:0006284; P:base-excision repair; IEA:EnsemblFungi.
DR GO; GO:0010791; P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing; IEA:EnsemblFungi.
DR GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR GO; GO:0035753; P:maintenance of DNA trinucleotide repeats; IEA:EnsemblFungi.
DR GO; GO:0010780; P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination; IEA:EnsemblFungi.
DR GO; GO:0097552; P:mitochondrial double-strand break repair via homologous recombination; IEA:EnsemblFungi.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000723; P:telomere maintenance; IEA:EnsemblFungi.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR NCBIfam; TIGR00583; mre11; 1.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003447};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003447};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|RuleBase:RU003447};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU003447};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003447};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU003447};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU003447};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU003447};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003447};
KW Reference proteome {ECO:0000313|Proteomes:UP000070444}.
FT DOMAIN 287..451
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KXN70006.1"
FT NON_TER 486
FT /evidence="ECO:0000313|EMBL:KXN70006.1"
SQ SEQUENCE 486 AA; 55559 MW; 5933B21A4C90A042 CRC64;
EKLKILISSD NHLGYMERDN IRGQDSINSF EEILNISNKK NVDMILLGGD LFHDNLPTRS
SLHACMSLIR QYTFGSGEKS SRSKLNIESD MTLNFMDRFG TANFLSGDFR VRLPIFSIHG
NHDDPSGVER LCSLDLLSTA GLVNYFGKFD RVDAIDVHPI LLTKGSVKVA LYGIGNVRDE
RLYRTFRNNN VNFYPPEDRD EWYNILVVHQ NRIAHSDTNF LPEAFLPKWM DLVIWGHEHQ
CIPNVEYNSE RSFQVLQPGS SVATALSIGE ADRKHAFILE VDSEKNGELK KIPLKTVRQF
EIDEISLSEF TELNSYTWEE ISVVIIDYIK KMVKKAEENF MALNKTATVV PLPLIRLKVT
YQEQISQLSP IRFYPLLEPL VANPKSCLKF YKQTPRKAKG EKSQSSGSQF NLSTQINLDN
LQLEDVLAEF NNATQFQLLP QTTLDRAVHK LIDKEDKYGV EKVIQGTVKE LQKGLTDEQV
LYKLDS
//
