ID   A0A137QY52_9AGAR        Unreviewed;      1660 AA.
AC   A0A137QY52;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=AN958_08703 {ECO:0000313|EMBL:KXN92250.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN92250.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN92250.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN92250.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ961916; KXN92250.1; -; Genomic_DNA.
DR   STRING; 1714833.A0A137QY52; -.
DR   OrthoDB; 147843at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 2.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KXN92250.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1074..1260
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1361..1628
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1660 AA;  187405 MW;  BCBB1D33836D5C67 CRC64;
     MDSEPSIDTY AWETMSESLV IDSVFILIHL ANTWLQKLAS VGSIALGEID KKLFARTTLL
     LSNESPISDN LVQEAALKAT AILVRSFPET AAFMATQLRR FVTSPLPLFE FEFAEGRAPP
     LAAAAKCLAL CIKLAPGDDL IMSNMYSLLN FIAATSKDTH DDLQGPDAHD PGTLHSLETG
     LRGLSEDEKR LTGISTISVV TRLALEFYTE EVTKLTISML LQRLRSAEPT VEAAIAYNLV
     DLALIAPEGS FIDIIRSFSA INRSANPDDP RFSNNMVLAA QTRLAQDLNR RPELFGMYLT
     ELLTLFLDKG VAIQNLRIGN PQVKIDDMIE QLASLLLPID ALLVHTNFKP WENTSPEAVS
     LFRNLWFLCV LFNFTATDDK DGTAMDWLRP ALRRIAAKTP PMVVEETHDA FASDIEYNTV
     IRQEYADSVL VKQRTRLTKY IMLRSSELRS LSTGQVVFLL AMHDIESLRA LEGLPSSLVT
     YFINESLNKN PVLSACMEGI AEQVIRGCQA ALTTKASQQA LPKRLSGELR QLVISSTHRI
     AKAREVASKY LNRLLVSFPS LMCDPHLVYA ILEVLTLLQR GTENEFIDEY EPTWEYHSDR
     ANITIQLTDN CQTRKEILDN LSRNANSWFE LALSRAPLEL QSTLQKYLAV NQSVTGTDSA
     ELGASIAERF GKDVGPVHRH LFSLKSLSRW NMDQAKTLTS QIAIKSYYLG EAAGFRFVGK
     EYCKSVRGAD TPQSEICALR EKLQSTMADI RSKNSSLTIQ ELRRLLYRCA AVLVSLDRCD
     YDLLHYVVTL PFAVATPSAM VVAAEIWSWL IAEKSACEVA LTSEIVSAWS LTIKHGRGIF
     SRHINYHDPF ESPIVYAPTD KEFMEKELTS ARKLLSPHIL VLHLLYSRLQ AARYYQPNIM
     FLIQQLVLRS TRNHKRFSTH ALAREPRFSF LLFGFEALKS SHLDAFCENL LREALYRLAF
     SWYSARAQWT YGADRAQLHA DLKALSEFLS YLQTDTVRGL PSISSLSPLQ SVSRTSCKTK
     LKPVYSLKRF LDYSARLRDL STPLRLLTES ELFRLSVWIN PTNDSKRSTD LVGATERGLI
     DTSWLDLIRC VWNIDPAIAI SLTERFKSPL VRNEVARLVR SSPKDVLGIS DAVHLLLGDG
     FDPNVRRDHK YLLLWAPVSP ITANTFFERR YNNQPQILQY AHRVLEEHPV ELTFFFIPQI
     VQALRYDTLG YVAQFIFETA KISQLFCHQI IWNMKANCFK DDAAEIEDPL KPTLDLMTDA
     VVNSLSGEAR DFYDREFNFF NEVTSISGKL KPFIKKTKPE KKAKIDEEMT KIRVDVGVYL
     PSNPDGVVVD IDKKSGRPLQ SHAKAPFMAT FKVRKERVEV ESDPDSVVDG AGIERRTEYD
     VWQQAIFKVG DDCRQDVLAL QVIAIFKNIY TNVGLPLYLF PYRVTATAPG CGVIDVVPNA
     TSRDEMGRAK VNDLLDFFIA KYGGQDTVAF QRARLNFVQS MAAYSLACYI LQIKDRHNGN
     IMIDGEGHIV HIDFGFLFDI DKLISLQGVK FEPNSFKLNH EMIVLMGGRY SQGYQLFQSL
     TVKAFLAIRP YAEQIVNTVQ LMLDTSLPSF KGEPTIRRLR DRFALQLNDR QAAEFMMSTI
     RNAHENVRST AYDEFQRVSE PPPNAIPSLI LPLHSCKTVR
//