ID A0A139CR60_9EURY Unreviewed; 804 AA.
AC A0A139CR60;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
DE Flags: Fragment;
GN ORFNames=AWU59_972 {ECO:0000313|EMBL:KXS43717.1};
OS Methanolobus sp. T82-4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX NCBI_TaxID=1794908 {ECO:0000313|EMBL:KXS43717.1, ECO:0000313|Proteomes:UP000074030};
RN [1] {ECO:0000313|EMBL:KXS43717.1, ECO:0000313|Proteomes:UP000074030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T82-4 {ECO:0000313|EMBL:KXS43717.1};
RA Wolfe R., Daly R., Wrighton K.;
RT "Methanolobus T82 Annotated.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC fragments with terminal 5'-phosphates, ATP is simultaneously
CC hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC -!- SIMILARITY: Belongs to the HsdR family.
CC {ECO:0000256|ARBA:ARBA00008598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXS43717.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSRV01000022; KXS43717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139CR60; -.
DR STRING; 1794908.AWU59_972; -.
DR PATRIC; fig|1794908.3.peg.2414; -.
DR Proteomes; UP000074030; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd18030; DEXHc_RE_I_HsdR; 1.
DR CDD; cd22332; HsdR_N; 1.
DR CDD; cd18800; SF2_C_EcoR124I-like; 1.
DR Gene3D; 3.90.1570.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR InterPro; IPR004473; Restrct_endonuc_typeI_HsdR.
DR InterPro; IPR040980; SWI2_SNF2.
DR InterPro; IPR021810; T1RH-like_C.
DR NCBIfam; TIGR00348; hsdR; 1.
DR PANTHER; PTHR30195:SF15; TYPE I RESTRICTION ENYME HINDI ENDONUCLEASE SUBUNIT; 1.
DR PANTHER; PTHR30195; TYPE I SITE-SPECIFIC DEOXYRIBONUCLEASE PROTEIN SUBUNIT M AND R; 1.
DR Pfam; PF04313; HSDR_N; 1.
DR Pfam; PF18766; SWI2_SNF2; 1.
DR Pfam; PF11867; T1RH-like_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT DOMAIN 292..474
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT NON_TER 804
FT /evidence="ECO:0000313|EMBL:KXS43717.1"
SQ SEQUENCE 804 AA; 91736 MW; EBA9F070F3960446 CRC64;
MSCIVSESEV EEAALEILTE LGYGYFYGPD IAPETPDSQR VTYSDVFLIE RLRAAIATLN
PHIPSPAREE ALKKVVRTES QDLIHSNQVF HNMLVNGVDV EYRNNEGEVV YDKVWLFDFK
EYSNNEYIAV NQFTVVENRN NRRPDIVLFI NGLPLVVMEL KRPEDDSEYE DDDLIWTAYN
QFQTYKDEIP SLFRYNAFLI ISDGQEARAG TITSSRQWFT SWKTIDGENT ADFLIPEMEV
LLKGMCNKDV ILDLVQNFMV FEGDHGPIIK KLARYHQYHA VNKAVQNTIE ASRPDGDRRC
GVIWHTQGSG KSLSMIFYAG KLVVDMDNPT IVVITDRNDL DGQLFESFAR CSSLLRQHPV
QANTGAELRD LLSVASGGIV FTTIQKFLPE NSEDSFPALT ERSNVIVIAD EAHRSQYGLE
MKMSQKDDEA RFSYGFAKHM RDALPNASFI GFTGTPIEFD DRNTPAIFGD YIDIYDIEQA
VKDGVTVKIF YENRLSRIDI VAEARNTLDT QFALLTEDRE EYESEKLKSR WSRLDAVVGS
KSNLKKLAAD IIPHFESRVA TPEGKGMIVC MNRRTCVDLY NEIIALRPNW HDDDDLKGAV
KVIITGSAAD EKSMQPHIRS KSKRMKIRDR MQDPDDPLKI VIVCDMWLTG FDAPCLHTMY
FIKWLKGHTL MQAIARVNRV FKDKPGGLIV DYVGLLYDLK YAMANYTRSG GRGKPADLKD
EAVDLMLEKY EIVRDMFHGF NYRRILTASP KEKLTIVREG ADFILSLGRT EQQSKHERKR
FIQHVTELSK AFALSKPHAQ ADLI
//
