ID   A0A139D5Y5_9FIRM        Unreviewed;       334 AA.
AC   A0A139D5Y5;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:KXS48944.1};
GN   ORFNames=AWL62_1483 {ECO:0000313|EMBL:KXS48944.1};
OS   Halanaerobium sp. T82-1.
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halanaerobium.
OX   NCBI_TaxID=1794808 {ECO:0000313|EMBL:KXS48944.1, ECO:0000313|Proteomes:UP000070487};
RN   [1] {ECO:0000313|EMBL:KXS48944.1, ECO:0000313|Proteomes:UP000070487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T82-1 {ECO:0000313|EMBL:KXS48944.1};
RA   Wolfe R., Daly R., Wrighton K.;
RT   "Halanaerobium-1 T82 Annotated.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the PdxA family. PdxA2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009464}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXS48944.1}.
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DR   EMBL; LSBN01000061; KXS48944.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A139D5Y5; -.
DR   PATRIC; fig|1794808.3.peg.1385; -.
DR   Proteomes; UP000070487; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR005255; PdxA_fam.
DR   NCBIfam; TIGR00557; pdxA; 1.
DR   PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR   Pfam; PF04166; PdxA; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ   SEQUENCE   334 AA;  36469 MW;  424EEF94DB14A211 CRC64;
     MSNYKNNIGI TMGDPAGVGP EIILKAFKDN HFKKSDRIVI IGDLNVLKKI NEKLSFNVLF
     NELGDNLNDL NTKYQEDKLN VVNLDNVDIK NLIPGKVSKN AGKAAVEFVL KGIDLAMDKK
     IDAVVTAPIN KKAIQTAGFK YPGHTEIFAE KTGAKDYAMM LYSDKLNVAH VSTHMSLLNA
     CKTLKKERVE KVIELANSSL KDLGIETPRI AVAGLNPHAG EQGLFGEEEI NEIKPAVDNA
     KEKGIEAYGP IPPDTVFVKA VNGEYDIVVV MYHDQGHIPV KLLGFDSGVN VTLGLPIIRT
     SVDHGTAFDI AWEGKAYDTS LIKAVEVAEK MAEK
//