ID A0A139H3R7_9PEZI Unreviewed; 2367 AA.
AC A0A139H3R7;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=AC578_2899 {ECO:0000313|EMBL:KXS97115.1};
OS Pseudocercospora eumusae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=321146 {ECO:0000313|EMBL:KXS97115.1, ECO:0000313|Proteomes:UP000070133};
RN [1] {ECO:0000313|EMBL:KXS97115.1, ECO:0000313|Proteomes:UP000070133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114824 {ECO:0000313|EMBL:KXS97115.1,
RC ECO:0000313|Proteomes:UP000070133};
RA Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT link between parallel evolutionary changes in Pseudocercospora fijiensis
RT and Pseudocercospora eumusae and increased virulence on the banana host.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXS97115.1}.
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DR EMBL; LFZN01000152; KXS97115.1; -; Genomic_DNA.
DR STRING; 321146.A0A139H3R7; -.
DR OrthoDB; 246127at2759; -.
DR Proteomes; UP000070133; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000070133};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2135..2266
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2367 AA; 274172 MW; CBA70908135D439D CRC64;
MSGIPPPPPP GWVPPPPPGA PPGLSSSSAP PPPPGFQPLK DPQAEKLQQK KQKWLRQQRQ
RFAEKRKGGF VETQKADMPP EHLRKIVRDI GDVSQKKFSA DKRSYLGALK FMPHAVLKLL
ENMPMPWESS REVKVLYHVN GCLTLVNEVP RVIEPVFHAQ WATMWVVMRR EKSDRRHFKR
MRFPPFDDEE PPLSWSENIE DVEPLEPIQM ELDENEDEPV YEWFYDHRPL SDTSHVNGPS
YKEWNLSLTQ MATLHRLSNP LLSDTTDKNY FHLFDMPAFA TAKALNVAIP GGPRFEPLYK
DIDPNDEDFG EFNAIDRIIF RAPIRTEYRV AFPYLYNSLP RSVKLGIYSY PQTVYVKTED
PNLPPFYFDP VINPISSRSV APKNLTVSHE DEIFGAGNNE EPDEEDGGFS LPGEVEPFLD
DHDLYNDDTA SAIALWWAPY PFDRRSGKMV RAQDVPLVKQ WYLEHVPQGQ PVKVRVSYQK
LLKTYVLNEL HKKPPKAQNK QNLCRSLKST KFFQQTTIDW VEAGLQVCRQ GFNMLNLLIH
RKNLTYLHLD YNFNLKPIKT LTTKERKKSR FGNAFHLMRE ILRLTKLIVD AQVQYRLGNI
DAFQLADGIL YAFNHVGQLT GMYRYKYKLM HQIRSCKDLK HLIYYRFNSG PVGKGPGCGF
WAPAWRVWLF FLRGIIPLLE RWLGNLLSRQ FEGRHSKGVA KTVTKQRVES HFDLELRASV
MADLMDMMPE GIKQSKVNTV LQHLSEAWRC WKSNIPWKVP GLPKPIEDII LRYVKSKADW
WVSVAHYNRE RIRRGATVDK TVAKKNLGRL TRLWLKAEQE RQHNYLKDGP YVSTEEGVAI
FTTAVHWLES RKFQPIPFPS VSYKHDTKIL ILALERLREA YSVKGRLNQS QREELALIEQ
AYDSPGTTLA RIKRFLLTQR SFKEVGIDMN DNYSSINPVY DIEPIEKITD AYLDQYLWYQ
ADQRRLFPAW IKPSDSEVPP LLTYKWAQGI NNLSNVWSVD EGECNVMLET RLDKVYEKMD
ITLLNRLLRL IMDHNLADYI SSKNNVQLNY KDMNHTNSYG MIRGLQFSAF VFQYYGLIID
LLLFGLQRAS EMAGPPNAPN DFLQFRDRAT ESRHPIRLYT RYIDKIWIFF RFNADESRDL
IQRFLTEQPD PNFENVIGYK NKKCWPRDSR MRLMRHDVNL GRAVFWDMKN RLPRSITTIE
WDDTFASVYS RDNPNLLFAM NGFEVRILPK IRNMNDEFPT KDSVWALVDN QTKERTAHAF
LQVTAEDIAK FNNRIRQILM SSGSTTFTKI ANKWNTTLIA LFTYYREAAV STVELLDTIV
KCETKIQTRV KIGLNSKMPS RFPPAVFYTP KELGGLGMIS GSHILIPASD KRWSKQTDSG
VSHFRAGMSH DEETLIPNIF RYIIPWESEF TDSQRVWTEY SQKRLEANQQ NRRLTLEDLE
DSWDRGLPRI NTLFQKDRST LSFDKGFRAR TEFKLYQHMK SNPFWWTSQR HDGKLWNLNA
YRTDVIQALG GVETILEHTL FKATAFPSWE GLFWEKASGF EESMKYKKLT NAQRSGLNQI
PNRRFTLWWS PTINRANVYV GFQVQLDLTG IFLHGKIPTL KISLIQIFRA HLWQKIHESV
VMDLCQVFDQ ELDALGIETV QKETIHPRKS YKMNSSCADI LLFASHKWSV SNPSLLYDTK
DNMGLTTTNK FWIDVQLRYG DYDSHDIERY VRAKYLDYTT DSMSIYPSAT GLMVGIDLAY
NLYSAYGQYF PGLKQLVQQA MAKIMKANPA LYVLRERIRK GLQLYASESN QEFLNSQNYS
ELFSNQIQLF IDDTNVYRVT IHKTFEGNLT TKPINGAIFI FNPRTGQLFL KIIHTSVWAG
QKRLGQLAKW KTAEEVAALI RSLPVEEQPK QLIVTRKGLL DPLEVHLLDF PNISIRASEL
QLPFQAAMKV EKLGDMILRA TEPQMVLFNL YDEWLKSISS YTAFSRLILI LRALHVNQDK
TKLLLRPDKT VITQEHHIWP TLSDDDWVKV EVQLRDLILN DYGKKNNVNT SSLTNSEIRD
IILGMEISAP SMQRQQAAEI EKQQEQEQLT AVTTKTQNVA GEEMIVTTTS AYEQQSFASK
TEWRTRAIAT SNLRTRANNI YISSEDIRDD EHHFTYVMPK NILKRFIAIS DLRVQVAGYL
YGTSPPDNKQ VKEIKSIVMV PQVGSTRDIQ LPRNLPENEM LSGLEPLGII HTTAGNETNY
MTAQDVTQHA KLMAAHPSWD RKTVTMTVNF TPGSVSLSAW SLTPQGYQWG AENKDLGSDQ
PVGFQTGFGE KSQLLLSDKI RGYFLVPEDE RWNWSFLGSG FGEHEKGRVY VNVGVPRRFY
DDVHRPIHFQ NFAELEDVWV DRSDNLA
//
