ID A0A139HAD0_9PEZI Unreviewed; 706 AA.
AC A0A139HAD0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 03-MAY-2023, entry version 21.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=AC578_8153 {ECO:0000313|EMBL:KXS99401.1};
OS Pseudocercospora eumusae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=321146 {ECO:0000313|EMBL:KXS99401.1, ECO:0000313|Proteomes:UP000070133};
RN [1] {ECO:0000313|EMBL:KXS99401.1, ECO:0000313|Proteomes:UP000070133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 114824 {ECO:0000313|EMBL:KXS99401.1,
RC ECO:0000313|Proteomes:UP000070133};
RA Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT link between parallel evolutionary changes in Pseudocercospora fijiensis
RT and Pseudocercospora eumusae and increased virulence on the banana host.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXS99401.1}.
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DR EMBL; LFZN01000092; KXS99401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139HAD0; -.
DR STRING; 321146.A0A139HAD0; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000070133; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 2.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000070133};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 217..411
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 484..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 76486 MW; CD25AD062C319594 CRC64;
MAQPTQLAYR TSKHIGVFDA APVYEAVPGF QRPEGNLRCS VYSPDGRFFA WASPEHVTVV
DASKGHVVTT LPADNVFELG FSPAGTFIIT WQRPSKDDEG NAVKNLKVWR TIDENAGEHG
ERAVVGKFVQ KNQTGWNLQY TQDEQFCARC VNNEVQFYES KDLATVWNKL RVEGVTDFAL
SPGKTNSVAV FVPERKGQPA AVKVFNVPQF TAPVSQKTFF KGDKVQLKWN QEGTSLIVLA
QTEVDKSNKS YYGETNMYIL SANGGFDSRI TLDKEGPIHD VTWSPNSKEF GVVYGYMPAK
TTIFNHRAIA QHSFNLGPRN TILFSPHGRF VIVAGFGNLA GQMDIYDLSK NYEKVCTIEA
SNASVCEWSP DGKHILTATT SPRLRVDNGI RIWHVGGGLM YNEDMTELYQ VTWRPQSATQ
HPVENALHPV PTPHPSALAY LGTRKTPSKP AGAYRPPGAR GTATPLAFKR EDEGGAAFVR
EMMSGKDPAT NGFGPRAPRP RHVPGAETVS GDLPPGAAPG GGVSLAQDGD ENLSKAALKN
KKKREAKRAK EAEAKSQGLQ APGQNGEGPH DRSQRSRSRS NTQRSNQQHG SRPHSRRRDA
PPPVNTGQPH SGAPAATKGR ANGAAVAPAA PAAAAAAEAP ELSVTSPGAG TPEEKKIRSL
LKKLRAIDDL KMRQAGGEKL EGTQVLKIGT EEQVRKELTA AGYTGD
//