ID A0A139IP44_9PEZI Unreviewed; 4337 AA.
AC A0A139IP44;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=AC579_1324 {ECO:0000313|EMBL:KXT16533.1};
OS Pseudocercospora musae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=113226 {ECO:0000313|EMBL:KXT16533.1, ECO:0000313|Proteomes:UP000073492};
RN [1] {ECO:0000313|EMBL:KXT16533.1, ECO:0000313|Proteomes:UP000073492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 116634 {ECO:0000313|EMBL:KXT16533.1,
RC ECO:0000313|Proteomes:UP000073492};
RA Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT link between parallel evolutionary changes in Pseudocercospora fijiensis
RT and Pseudocercospora eumusae and increased virulence on the banana host.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXT16533.1}.
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DR EMBL; LFZO01000035; KXT16533.1; -; Genomic_DNA.
DR STRING; 113226.A0A139IP44; -.
DR Proteomes; UP000073492; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000073492}.
FT DOMAIN 1920..2058
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2211..2363
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2575..2725
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2917..3083
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3179..3263
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3405..3446
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4337 AA; 490580 MW; 0BE92B17E496FA67 CRC64;
MEGPVVQGVN GLGAANGTPP APAPTPASSA VDPQAIIKYL SNVLEVTLGA TDDELRGPGS
LLHESVIEET LARCLRFALE AQVALYVLKQ ASAAGTQGKE NGTYTNGDRE HHQDTYVLSS
EVSYSNRTVG CVAFLKRPSS IVPDVALSQQ VSVVNMSLPG NLGAEGAGPT VSPYESLHSF
VKGALTPFFE AAARGSESTG KKLRSDGESR TGISGARRKL ADLEITLQNL QQNIEVEAPR
LQIHEAVQMQ LNEANGDWQA AAVTIPDSIV TDSSMLNRLQ NMANDWIKQI REFTRITDDR
AVGTTSQEKN FWLAMETAID GIESQLASGG VKLTMTILEK AKRHGITASF QSDTRLKETK
DTVARYNQLF HGFPIEELLA APTVEKLREA LDDVFSHLNK KLRICPYPIK RALPLVEAIS
ADVDARIHQL LHGRKLMHMS FPDFRRQIEE VQTVWMFWDD NVKEFTNVAR DVTRRRNDKF
IPIKINRRHD KTQDRIKYIF KFRDDHEQLQ NTIANVLGPE EDSADLTDAA NGPVIVEEMG
DVDAAEEIAQ AYTAVKDVDV LDISPEGERL WTQAETAYNE RTARVENSII ARLRDRLAVA
KTANEMFRVF SRFNALFVRP KIKGAIAEYQ AQLLSNVRDD IDGLQKRFTH QYGQSESHGM
AQLHDLPPIS GAIIRAKQIE RQLDNHLSKV EDILGHKWRD HTDGARLNQL CDGFKRKLDT
KPIFEDWLRD IDRRHLSISG RLFSVTQNRA RQNTLEIHVN FDSQVIILFK EVRNLLWLGF
NVPHAITNVS KEARRVYPYA VSLMESLNTF GQTNLAIENM SNVTDLISGY RNDVQKYIGK
GASLRWDTFV LAYDVHVSRS GEGSLSGGSD DKLHVRFVRD LGNAIATLQQ KVTTLSTIQV
TVEAALRELQ SCPFTHEAFS THLETLQRAI DQLNLESYSN IAIWVAKTNE KVLETLHARL
QQALKDWIED FEHGCGAEQP VQREAGTPNI DTFAHDIVMQ SQVIQLEPPL QDAKTGWLDN
VHTWIGTVCS LSRLQASRFE NALTVGSSGQ TTAYSELPIM CMDSLAELYD RIEGKLGVAQ
TYVDEWLQFQ SLWDLQLQQI QDDLGEELDL WLQLILEIRQ KRETFDTSGM RRSFGHLVIN
YEQVQAKVNA KYDQWQHDLL THFSSMFATR MVDVYSELQR ARKDLEGQSM QASSTSQAVS
FITVVQTVKR QTKVWEPEMD TFRQGQQTLS RLRFPYPKDW LYVEQVDHEW AALVEVLEKK
SKQINDHTEG LRTKIIAEDG VVSRRIAEMT EKWREERPES GSTPPAEATA SLESFDTELT
QLQEQYDMVS KAKEALELPA SPDNMLADLL AEVQDYKSVW ANLTVVWDQL NDLKDQPWNS
IQPRKLRQSI DNLIKTTKEM PSRMRSYAAF EHLQNHLRQL LKINPLLTEM RSDAVRERHW
TKIFKSLAPS KRYSALSMTL GDVWDLNLVA SEAVIRDVIA QAQGEMALEE FVRSVREHWQ
NYSLDLVPYQ TKCRLIRGWD DLFAKCSDHL NSLQAMRHSP YYKEFEEEAS SWEDKLNRIH
VLFDVWIDVQ RQWVYLEGVF TGNADIKHLL PVESSRFANI NSEFMNVLKK VYRSPQVLEV
LNIPDVQKSL ERLADLLNKI QKALGEYLEK ERVAFPRFYF VGDEDLLEII GNSNDTVRIA
KHLRKMFAGI AGLEIDDEQN INALVSREGE QMRLRSPISL IQTPKINDWL RALENGMRET
LSELLVEAIQ EYQGIEESDE AAFDVYVVKY PAQIVVLATQ AHWTAQVTAA LSQGVSGLQK
LFESLVNRLK HLAKSVLQEM EPVLRKKSEH LITEFVHQRD KTEQLIEGGA DSPDHYLWLL
QMRYEFDASA PPLDRLQVQV ANATLAYGFE YLGVPERLVR TPLTDRCFLT LSQALCQRLG
GSPYGPAGTG KTESVKALGV QLGRFTLVFN CDDTFDFQAM GRIFLGISQV GAWGCFDEFN
RLEERILSAV SQQIQNIQVG LRKRALDPSA QIDLVGRQLK VHPLTGMFIT MNPGYAGRSN
LPDNLKKLFR SVAMSKPDKE IIAEVMLFSQ GFSEAKTLSR QTVPFFDQCG ARLSKQPHYD
FGLRALKSVL VSSGGLKRAR LAAGSEQSSD VVVEPQIIVQ SIRETIAPKL VRDDALLMAE
VEEEAFPGVQ YMPASLDKLR EALQDIVEER KLVATDAWLT KVLQLYQIQS LHHGVMMVGS
SGTGKSTAWQ TLLAALQKVD GIEGVCHVID PKVMSKESLY GTLDSTTREW TDGLFTSILR
KVVDNLRGED SKRHWIVFDG DVDPEWVENL NSVLDDNKLL TLPNGERLGL PSNVRVMFEV
ETLKYATLAT VSRCGMVWFS DDTVDVDVML SRYIAQLRTA TFDDLEEDTG TPTSTEARLA
VQNLMAEILN RRLNENDFVR KGLQHCASMK HIMEFTSIRA LGTLFSLLRK SCRSVLEYNI
NHADFPLNDE QIEAYLSKKV LLAAVWSFTG DCPLVDRKAF GDYLAGLATL DMPVLAEQTS
LIDYDVSLPE ATWLSWQNQV PSIEVNTHSV TQTDLVIPTL DTVRHEDVLY SFLAEHKPLL
LCGPPGSGKT MTLFSALRKL PNMEVVGLNF SSATTPDLLV KTLEQYCDYK KSISGVTMAP
RQIGRWLVVF CDEINLPAPD KYGTQRVISF LRQLVEHGGF WRTSTRSWVS LERIQFVGAC
NPPTDAGRTP LGLRFLRHAP LVMVDYPGEL SLKQIYGTFN NAVLKIIPTL RGYADALTQA
MIQVYLQSQK RFTPEIQPHY VYSPRELTRW VRAIYEAVRP LETLSLEGLV RIWAHEALRL
FSDRLIADEE RQWTEEAVNR VALEHFPNIN EEQALQRPIL FSNWLSKDYV PVARDQLRDF
VKARLRTFCE EELDVPLILF NDVLEHVLRI DRVFRQPQGH LILIGVSGSG KTTLSRFVAW
MNGLSVFQIK VHGRYSSEDF DEDLRTVLRK CGCKGEKICF IMDESNVLDS GFLERMNTLL
ANGEVPGLFE GDEYATLMTA CKEGAQRQGL LLDSQEELYK WFTQQIVRNL HVVFTMNPPS
DGLGSKAATS PALFNRCVLN WFGDWSDQAL YQVAYELTQS VDIDKGNYTC PDSLPIEFDQ
LEMPLSHRDA VVNGMVHVHH SLRTFNDRLK RQQNKQTFLT PRQFLDFVAQ FVKLFNEKRD
DLEEQQRHLN VGLDKLRETV EKVSELKRSL AVKKSELERK DTEASEKLQR MVADQREAEQ
RRAASLEIQA ALEKQEKEVA KRREVVLNDL AKAEPAVEEA QRSVSNIKRQ HLTEVRSMQN
PPSGVKLALE SVCTLLGHKA ADWKSIVSIV RRDDFIASIV GYDNERQMTP QLRAKMRAEF
LNKEDFTFER VNRASKACGP LVQWVEAQVN YSEILDRVGP LREEVDQLQE EALQTKAEAK
AIENTLQELE QSIATYKSEY ASLISQTEAI KAEMTRVQSK VDRSMRLLNS LSSERGRWEE
SSKTFQVQME TIIGDVLLAS AFLAYAGLYD QQYRRAMLED WSLQLSASGI AFKAQNSLSE
YLSTADERQQ WHEHALPVDE LCTENAVMLK RYNRYPLIID PSGRVTEFLQ NESKDRRLTV
TSFLDGSFVK QLESALRFGN PILIQDAEHI DPILNHVLNK EYQRTGGRVL IQLGRQEIDF
SPAFKLYLST KDPSAPFAPD VCSRTTFVNF TVTQSSLKTQ TLNDVLKSER PDVDERRSNL
VKMQGEFTQR LRRLERMLLQ ALNESRGNIL DDENVIQTLE TLKNEAAEIT AKASETEGVM
NEVNNIMSTY EIIAQSCSAI FAVLEQLYHI HHFYQFSLQY FVNIFESVLR GAREANERDA
KKRIDSIVRA LFGKTYSETS ASLLQKDRLT FAVLLAQAAP FPMDKTLLDL LLDESVMGGD
VTTNPEQKQK AVTIASRITS VKELVGDVDN EAWQKFFSTE QAEHCVPGTA ATTNENDRVL
KELLLVKLFR MDRLVPATEH FVNTVFGQDF LDVAENLGRI AQETTASSPI ALCSTPGFDA
SYKVDQLVER QNASCTSVAM GSNESMSSAD SALASAAANG SWVLIKNVHL ATEWLQNLVK
RIDSLKPHPD FRLFLSMETS SKIPSSLLRT SRVLMYEQPA GIRANMRDTL TSLPDKAVSQ
PVEKARVHFL LAFLHAVVQE RLRYAPNLGW KGFWEFNDAD FDCSAFIIQW WTDHVARGRS
NIAPKCIPWD ILRCLIAEMY GGKVDNADDM SVLRSLVERT LTSDAFEDGF NLIGKVAEDE
SVGVALPGGS SKAVFLQWVK ESLPEREPPT YLGLPANAEK LLLVAHAKNM LGDLKTVMRV
LDEGEMDMAE AVTEGAA
//
