ID A0A139TPZ3_9BACT Unreviewed; 378 AA.
AC A0A139TPZ3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Putative thiazole biosynthesis protein ThiH {ECO:0000313|EMBL:KXU53659.1};
GN ORFNames=HMPREF3039_02191 {ECO:0000313|EMBL:KXU53659.1};
OS Akkermansia sp. KLE1798.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1574265 {ECO:0000313|EMBL:KXU53659.1, ECO:0000313|Proteomes:UP000070454};
RN [1] {ECO:0000313|EMBL:KXU53659.1, ECO:0000313|Proteomes:UP000070454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLE1798 {ECO:0000313|EMBL:KXU53659.1,
RC ECO:0000313|Proteomes:UP000070454};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU53659.1}.
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DR EMBL; LTZM01000046; KXU53659.1; -; Genomic_DNA.
DR RefSeq; WP_067572701.1; NZ_KQ971087.1.
DR AlphaFoldDB; A0A139TPZ3; -.
DR PATRIC; fig|1574265.3.peg.2132; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000070454; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 50..275
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 378 AA; 42774 MW; B72ACE0B99FF8B66 CRC64;
MSFSEELSTL TAHPSPLVRR FMSLLEPVDD ARLEAMAQES RRLTRLHFGR TIRLFAPIYL
SNECINNCKY CGFSRDNPII RTTLTVDEVV QEARYLHGLG LRSILLVAGE HPKFVSDGYI
QKCLDALHPF IPSLGLEIGP LPDDRYAEIV HHGAEQLAVY QETYDREVYE TLHTAGMKKN
FNWRLDCPER AYQGGFRRIQ IGALFGLAPW RREAVALAAH LDYLQKHCWK AALSVAFPRM
RPYAGNYEYE PDPELMLDDR HFVQLMTALR ICFPKIGMSV STREPEPMRN ALMHLGMTHM
SAIARTEPGG YTGVGTATAH LTVRGNVVDL PEEKKGQCKA TEQFEISDQR SPEQVVCAIR
GAGLEPVWKD WDSGLDVV
//
