ID A0A143G4B0_9GAMM Unreviewed; 350 AA.
AC A0A143G4B0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:AMW79064.1};
GN ORFNames=AMD27_09300 {ECO:0000313|EMBL:AMW79064.1};
OS Acinetobacter sp. TGL-Y2.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1407071 {ECO:0000313|EMBL:AMW79064.1, ECO:0000313|Proteomes:UP000076238};
RN [1] {ECO:0000313|Proteomes:UP000076238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TGL-Y2 {ECO:0000313|Proteomes:UP000076238};
RA Zhang G.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP015110; AMW79064.1; -; Genomic_DNA.
DR RefSeq; WP_067659427.1; NZ_CP015110.1.
DR AlphaFoldDB; A0A143G4B0; -.
DR STRING; 1407071.AMD27_09300; -.
DR KEGG; acv:AMD27_09300; -.
DR OrthoDB; 9771084at2; -.
DR Proteomes; UP000076238; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000076238};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 9..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 350 AA; 38149 MW; 1ECCF0377796374A CRC64;
MTQQILAYAA LDSKSPLVPF KFEQRKARAD DVIIDIEYCG VCHSDLHQAR NDWGGSQYPI
VPGHEVVGRV KSIGSAVTKF KVGDLVGIGC MVDSCRTCSA CHEGLEQYCE QGNTGTYNSL
DRHDKSVTYG GYSQTIICSE AFVLKVPENL DTQAVAPLLC AGITTWSPLR HWKVGPQSKV
AVVGLGGLGH MAIKLAHALG AEVTLFTRSA SKEADAKVLG ANHIVLSTDE KQMKAARNQF
DLIIDTVPYD HDLKPYIPTL ALSGTLVLVG YLGQISANSV PMIMGRKSIA GSLIGGIQET
QELLNFCGEH NIVSDVEMID MQNINDAYER MLKSDVKYRF VIDLKSLKDE
//
