ID A0A143HIE4_9GAMM Unreviewed; 543 AA.
AC A0A143HIE4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=TldD protein {ECO:0000313|EMBL:AMX01277.1};
GN ORFNames=A3224_00605 {ECO:0000313|EMBL:AMX01277.1}, SAMN05660479_01439
GN {ECO:0000313|EMBL:SFC30377.1};
OS Microbulbifer thermotolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=252514 {ECO:0000313|EMBL:AMX01277.1, ECO:0000313|Proteomes:UP000076077};
RN [1] {ECO:0000313|Proteomes:UP000076077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAU221 {ECO:0000313|Proteomes:UP000076077};
RA Lee Y.-S., Choi Y.-L.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AMX01277.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAU221 {ECO:0000313|EMBL:AMX01277.1};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SFC30377.1, ECO:0000313|Proteomes:UP000181967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19189 {ECO:0000313|EMBL:SFC30377.1,
RC ECO:0000313|Proteomes:UP000181967};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP014864; AMX01277.1; -; Genomic_DNA.
DR EMBL; FOKT01000004; SFC30377.1; -; Genomic_DNA.
DR RefSeq; WP_067150096.1; NZ_JAPHQH010000001.1.
DR AlphaFoldDB; A0A143HIE4; -.
DR STRING; 252514.A3224_00605; -.
DR GeneID; 76606544; -.
DR KEGG; mthd:A3224_00605; -.
DR OrthoDB; 9803213at2; -.
DR Proteomes; UP000076077; Chromosome.
DR Proteomes; UP000181967; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF10; CONSERVED PROTEIN; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000076077}.
FT DOMAIN 60..124
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 158..278
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 287..535
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 543 AA; 59832 MW; 28E3FB2566BF43FA CRC64;
MDRRKFLQLS GAGLGFSMLP LSGVAVAEAK LTQSGIDIAV KKELADAALN TATKLGASYA
DVRIGRYLNQ FVITREMKVQ NVVNTESLGM GVRVIANGTW GFAATNDMTV DGISRAAAQA
VATAKANSRY QEEPVQLAKQ KGFGEVSWRT PIQKNAIAMP LAEKVDLLME VNKAALDSGA
DFVNSMLFLV NEQKYFASTD GSYIDQDVHR LWAPFEVTAV DKKSGAFRSR RGLSQPVGRG
FEYLDGRKED KIQSQTVLYR DSYDMLEDAR LAAEQAREKL SAKSVKPGKY DLVLDPSHLW
LTIHESVGHP LELDRVLGYE ANFAGTSFAT IDKWRSGKFQ YGSDKVNFVA DKVQPGSLGA
VGYDDEGVKT GSWELVKDGV LVNYQAIRDQ VHMLGQKASH GCCYADSWSS VQFQRMPNVS
LMPGKETLSV EDMIKDVEKG IYIIGDGSFS IDQQRYNFQF GGQLFYEIEN GKITGMLEDV
AYQSNTQEFW NACSQICDKR DYRLGGSFFD GKGQPQQVSA VSHGSATARF NGVNVINTKR
KLG
//
