ID A0A151B4Q1_9CLOT Unreviewed; 1802 AA.
AC A0A151B4Q1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Diguanylate cyclase DosC {ECO:0000313|EMBL:KYH34879.1};
DE EC=2.7.7.65 {ECO:0000313|EMBL:KYH34879.1};
GN Name=dosC {ECO:0000313|EMBL:KYH34879.1};
GN ORFNames=CLTEP_12010 {ECO:0000313|EMBL:KYH34879.1};
OS Clostridium tepidiprofundi DSM 19306.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121338 {ECO:0000313|EMBL:KYH34879.1, ECO:0000313|Proteomes:UP000075531};
RN [1] {ECO:0000313|EMBL:KYH34879.1, ECO:0000313|Proteomes:UP000075531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19306 {ECO:0000313|EMBL:KYH34879.1,
RC ECO:0000313|Proteomes:UP000075531};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium tepidiprofundi DSM 19306.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYH34879.1}.
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DR EMBL; LTBA01000009; KYH34879.1; -; Genomic_DNA.
DR RefSeq; WP_066823998.1; NZ_LTBA01000009.1.
DR STRING; 1121338.CLTEP_12010; -.
DR PATRIC; fig|1121338.3.peg.1233; -.
DR OrthoDB; 9805474at2; -.
DR Proteomes; UP000075531; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0052621; F:diguanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleotidyltransferase {ECO:0000313|EMBL:KYH34879.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000075531};
KW Transferase {ECO:0000313|EMBL:KYH34879.1}.
FT DOMAIN 8..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1496..1627
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 1802 AA; 211331 MW; 3E87B8EAC3F8CA02 CRC64;
MKIINNRYRI IRKLSHSKVK SSFLVSDVLK NSKRVKIDIL NSEYIPEKLI NFYVESFIKL
SNIISSNIIR VYDFGLVKFI DSKALEKKQY FYTSEYFEKS EKLIDVVNIE DNENILEFFV
QICYAINYLH LRGMFYNSIN TDNILIIKDN GTKRVMLKDM ASIELEKYFY SQGKGNIKYS
SKSSILYNNM ASNSTDMYLL GESMFYLLCK KNNRFEETYA YDELIEKIDE FALYHCDNEF
DLNILKIIRN MVKEPSDRQF ENIGQVIEEI NKTFNKQYKY YKRNEIERLT FNFELIGREY
EKSEVIKTYD MIKNGAISSS FIFIHGEMGI GKTKLLKNIE YTLRLDGANI YSSYGLNMVN
KGTNKAFIEI LKKIIIESNN INLSKYDSEL IKFIPELSKR RNVIPSKPLD GNKEKLRLIN
RSSGFVNEVI CNRKVVFIID NFHLADEFTI DFFKYLLFHD LGNFLFVVSY CDGECLLNKE
FIRFMNEIFQ KSNSKRILLE GLNIGQTSKM IQNILNMPKE PMKFTESIYA KTRGNPLFVK
EIIKNLFTKK IIYIDKKTGQ WFTDYKNEEL PIPINIEQAV LVQIKETDEF SYKILSIISI
FNKPVSINII KEFIDADKEK IEKTVECLMT KGVLCKHIED KGFAYDYYNM ILKNAIYNKI
CIEDRNKNHK LAAAILENQY KDGREEYLQE LIYHLERSYQ KQKIIDYCVK NSQKMLKFKN
TSDALKNLEK ALSMYDKESV EQNKIDIVYL IANIYFENSE YDLAMTYFRN LIDISINVGN
KIYQIYAMNK IAKIYMDRNK FDIMKDIIKE VEKLLRNVKC IEGYIEWSYL QAYVYLINQE
YKKGEELCEK SLKLCGNKCY ELKGRLYNIL GNIYLQNSET DKAIMCFKAS IINFEVVKQI
KGVIIASNNI GVIYGDFYQN FDEALKYYYK ILKICIDNNF ILWETKVKTN IASIYFNKTN
YKMVIEYLEN VIDVCEKNNF KGYLFNAYVV IANTYLRINK FDKAFKYYQI SSDEMDEQID
KIRFSGEYRI MEAELHLKFG DIKIAKESIG KALNIYKYEK SILKTKAELL LFIINILDGQ
ENIDDNIIVE FKDILGRYSN IENRLEIIYE VCIHLYKNKK NDLLYKIFNY AEKLDCDIKQ
KCIKAKRLFL KSLFEKNELK KLELLINALD MSKDDKCICW NIYVDMGDYY FRRSRYYYAL
IYYFEACHVA KSLLLSIPEN YRVNFAKFKC ISEPFNKFIN AKNYINNCSY LDVCNKGITS
LGDINELFSF VDYNDVINDE KIICFARKLY NLSFYDDVRD INDVLIYLNN NDVSNINMIN
KYMAYMTLAS TSLIILDEND EFNVIASTSA NTVLDKDKLK IINKVKDTSN VLMVSKFYNS
LYEVGILPKD MSAVMCLPII INDVYDDCFE DNRRKNMFDR EIIQGYIYME SNRSLNNFTY
TTLKECLIVS KLVGVILDKI KIKTDASIDK LTGTLTRKYL ELNIKEVLEK ANNYGGKFSM
IMFDLDDFKS INDNFGHQTG DFVLSKICEI VKKSIRKSDI LGRYGGEEFI VILPNTDIDD
AEIVAEKLRS NVHNSRLLGD KREITISMGL VNYPRHAQWG NELIEKVDQA LYVAKENGKN
QYRVWSDEFK DTIKRSNKLS GIITGNSVQD QRNVLTMIEL VNLIDEELSK DEKIFKFLGR
IIETTEAEKG MLAIVKNGRI EKKYCREIFK SKYVENINYN ENIINFVISK KEGTYLIDWD
NITKYNNITG VPDWNSVICV PITQNKTVLG VVYLCVSTAQ KEFNFGDFNF VNILSELAIP
II
//
