ID A0A151BG20_9ARCH Unreviewed; 256 AA.
AC A0A151BG20;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Type II methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.113 {ECO:0000256|RuleBase:RU362026};
DE AltName: Full=N-4 cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU362026};
DE Flags: Fragment;
GN ORFNames=AYL31_010660 {ECO:0000313|EMBL:KYH38831.1};
OS Candidatus Bathyarchaeota archaeon B26-1.
OC Archaea; Candidatus Bathyarchaeota.
OX NCBI_TaxID=1779370 {ECO:0000313|EMBL:KYH38831.1, ECO:0000313|Proteomes:UP000075365};
RN [1] {ECO:0000313|EMBL:KYH38831.1, ECO:0000313|Proteomes:UP000075365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B26-1 {ECO:0000313|EMBL:KYH38831.1};
RA He Y., Li M., Perumal V., Feng X., Fang J., Xie J., Sievert S., Wang F.;
RT "Evidence for homoacetogenesis among multiple lineages of the archaeal
RT phylum Bathyarchaeota widespread in marine sediments.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|RuleBase:RU362026};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU362026}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYH38831.1}.
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DR EMBL; LUCD01000103; KYH38831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151BG20; -.
DR STRING; 1779370.AYL31_010660; -.
DR Proteomes; UP000075365; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU362026};
KW Restriction system {ECO:0000256|RuleBase:RU362026};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|RuleBase:RU362026};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 50..246
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
FT NON_TER 256
FT /evidence="ECO:0000313|EMBL:KYH38831.1"
SQ SEQUENCE 256 AA; 29627 MW; E6CA7491FEDE7A83 CRC64;
MKELRRSPSR PLQPRSNREG EKTVKVLRID DSHIVIFDDF RNVELDEKAD LVFADPPFGI
GFKGNLQTYH RTPDALSYVE VPKEEYPDFI RSLLEWSYNV LKDSGSMWLL SGWNNLRVVL
DAVEDAGFTQ INHCIWKYQF GVFTRRRFTT SHYHLLLLAK DPNNYTFNKP EHYAEDVWYI
KRPYRHGVET AGNELPDELV EKCIRTSSNK GDLVVDPVLG SGTTMRVCLK TGRRCIGIEI
NPALEKRIKQ KLGLNP
//
