ID A0A151GBI0_9HYPO Unreviewed; 3204 AA.
AC A0A151GBI0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Non-ribosomal peptide synthetase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DCS_06362 {ECO:0000313|EMBL:KYK54404.1};
OS Drechmeria coniospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Drechmeria.
OX NCBI_TaxID=98403 {ECO:0000313|EMBL:KYK54404.1, ECO:0000313|Proteomes:UP000076580};
RN [1] {ECO:0000313|EMBL:KYK54404.1, ECO:0000313|Proteomes:UP000076580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 6962 {ECO:0000313|EMBL:KYK54404.1,
RC ECO:0000313|Proteomes:UP000076580};
RX PubMed=26975455; DOI=10.1038/srep23122;
RA Zhang L., Zhou Z., Guo Q., Fokkens L., Miskei M., Pocsi I., Zhang W.,
RA Chen M., Wang L., Sun Y., Donzelli B.G., Gibson D.M., Nelson D.R.,
RA Luo J.G., Rep M., Liu H., Yang S., Wang J., Krasnoff S.B., Xu Y.,
RA Molnar I., Lin M.;
RT "Insights into Adaptations to a Near-Obligate Nematode Endoparasitic
RT Lifestyle from the Finished Genome of Drechmeria coniospora.";
RL Sci. Rep. 6:23122-23122(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYK54404.1}.
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DR EMBL; LAYC01000003; KYK54404.1; -; Genomic_DNA.
DR STRING; 98403.A0A151GBI0; -.
DR InParanoid; A0A151GBI0; -.
DR OrthoDB; 1949608at2759; -.
DR Proteomes; UP000076580; Chromosome 03.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076580};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 978..1055
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1109..1522
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1613..1689
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2704..2782
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1597..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3204 AA; 351239 MW; 54D12E39BFB7B384 CRC64;
MHLLSGPPLQ GNPQGLALTR EEGSPETAYP LTKSQESIWL EYQKDASSTK YNVTLEWEIS
DATKGAPCVR QVLQAIYALT ERHAILRSTI TSIDGAPHLT EWNTGIVDPD IHMVCRNNTI
SEQSLSRLLR RPFSLEVDPP VRWTVIQCPT ALRVFLVGHH IVVDGHALSV LSKEFVVMLN
DDGAQLPPPP SFSSMNLIEQ QWLGSQSYLD SCKSVIDQVR TKNNSQWPRT TAAHKMTPEN
SAYRAIYTMH DFTIDELTAW GQQYSTTWFR VVSSVLALLV IDQTRPQFGM DEVLSVGFRG
RPEGMHACVG QFANSLPVKF PLWEAQKQTG TFKTLVALVS KNISMVKKSE LLSDMEIVPL
AKTLNLDYQP PRIAITCPPK LANDNCHLYP LEGSWDVLFY FEHHLAGVKL GVIYDPAFVS
STQLNSMKLL LRNLVTISRR PDALLSEMLE WIPTYASLPA AVQSPQGNPM KHVHHWIQAH
ADTSPNSMAL YSKEMKTSMT YGALDISAES KAKCLIVNGV PARGRVLINV RRGFQVIEWI
FAVFKCGSAF AYMDPTLAEK QKAIIVRNFK PSLVVDDAFL RDVYSSFQEG TSEVNTKITS
NNTAGDDLAY MIYTSGSTGE PKGVMVEHQN IAAFIQSSIS AARCGFGSRI LQLAAFTFDA
SILEWATALC TGGSLCFAQY PERLVGDYLA DVIDENKISF LQITPTALET LPVSRKVPTL
RYISVGGEAP SRETFAKWHS RVDLINVYGP TEAAVAVTYN LMEKATPLSK FVSAGIPNRG
TGIHICDEGF GPILEQGVGE ICISGAQVAR GYCENPTITA RNFAVHSSGI RMYRTGDRGM
FLDDGSLVVL GRIDRELKIR GFRIAPEEIE NAILEAGIGC HEASVQKSEN GLEMIAFVSP
ATISPSELRT LLRNSLPGYK VPSRFYPLPT LPKSTTGKID HKKVRMNLSK LTEEHDLGAS
LFPDDHASER KGYTSRASIQ ETTEEMVQRI WQQVLGASNS LPKDVNFFDV GGHSLLMPKL
HEGLKAAFPT ISVRLVDLFQ HSTIHSQTLL LQGNSGGRSE VVTPFETAPG SSTHSSLRVS
TVASPGIVTG ATSPAILTPP LVEIDTNHHS GVAIVGLAGR FPKAANANEF YDKLMDGYSG
ITDFKKRTEP EAIPEAIWVP RAGVLDNIER FDNDFWKLSK EDATDMDPQH RIFMEVAHEA
LADAGMEAAD LRRECVGLFI GAASDSYHLH TKSVIKDPFL LQTKSSMTPS ISARAAYHLN
LSGPNATVQT SCASSTVAFA MAYDAIRLGR CNVAIVGGVS IQLYEGGYLT RKGHILSTRG
ECNPFDSRAD GQVPSDAVTA VVLRGYTAAT EASTVSYANV MAAASGSDGA IDKAGFQVPS
ARGQAEVIKA AWRDAKVPSQ GLQYAEIHGS GTVVGDALEL EGLGLAMKEL KLDGTRIAVG
TAKGNIGNTQ QSSGLVSLIK LCKSMQNGLV PAIKGLDEVH PAIDDTLPID FARRRMRLHP
GNLLAVSALG WGGVNCHIVL GFPREHLLKR STKVLSESSF NHRILAAPRL KKAPIPVNHT
AASQVTFASD NSNDHPAPAT KPISLKERHV NEVKIDKAEQ IQHSRTQSDE NKQQKSDVEM
ELKKLWASVL VKPDTSISSS DSFLQIGGDS ISALRLVSVA RRHNIGLTVA MVFQHPQLSE
MAAHAKVVKD EMSGIVRPFS LISNNEVDEV MNEIRDQCGL WPEQTIEDAY PCTTLQEGLM
ALSVTRPGSY ILRNVFRLAS HVDVSRFKAA WEMTVKKCAN LRTRIVLVGD QHIQAEVTED
VLWRSVRTAN PKAFLKSDHK LVMGYGTPLS RYTLLEDEGS NPKRYFVWTA HHAVFDGWTM
QNIIKIFTSA YERSRIPSIR PFSAFVDYTM KLKAEESKAY WKEQLSGAQR SIFPFVEDEA
KIGQDTKTTT QILQLQQRSQ SSITKATIIR AAWAIVLARY NESDDICFGT VVSGRQAPVV
DVESVTGPMI ATVPVRVRLD KEQTVANFLH DVQAQALNMV PFEQFGLQNI AKVSDDAKKA
CELSNLIAVQ PMEQMSSFDG DCSEVFVQTD DDEYDANEIL ESYFTYPLVA QAKVFESHIS
FEVTHKVDVV SEARIVALGH HMEHVTAQLL MCADSSDDKT MLLGDLSVAG SWDLQQATDF
NMMEDPDSAD ACLHDVISQE SQKASSREAI YTKDVSFTYG DLDQHSTRLA HELVRAGVQG
ETVPFCFEKS AWEIVAMLGI LKAGAAFMPL DPSYPVRYRS KLMAQVSART VLASPQTSPL
FQSDAFNVIV LSSSSPFLTS TSSIEPQKLP QCTKNSAAYV LFPSKSTGKH RGVVIEHSAA
SSSFLALQKK LNIGTTTRHL QFSNYTSDTC IGEILGTLAC GGTICVPSED DQLQNLAAFI
TQARVNTAVL TPTVLETLIP GQTPTLTQIL VVGMKLTKDI VDVWADRVSL IRIYGPPEAC
NVATMHAFSS PEESTSIIGR GANSLAWIAD ILHPSRLAPI GCVGELVIQG PGLARGYLND
DEGTTHSFTD AVDFLPPQQI SRTAKFYRTG DLVQYNSDGE LEYVSRKATQ RKICGQRFDL
GDVEYRVREL GQGQISNLAA EVLQLQEVEF LAVFINLTED ETSTQATSIL PNTGPRQVFL
KDLEQRISER IPSYMVPSYC IPVSRLPKSA AGEIDRAALR QLAESLAAQD LLPYSASRGS
LFRDCSNDLE ARLRKIWAQV LGIPTESISV DDDFYQLGGD SIRIITLMKL MKKQLGISIS
ISTLIGRKTT VSRIAAIVQS SSSIASPSEM PQIDVMSKLL AITDEAWAAE ANLARIGAVA
TLSENATVFL TGATGFLGTE ILRQLLQKKQ IRTVAVLVRA TSTLQGLQRI KRTAVIAKWW
NDAYEEKLEI WTGDLGAKQL GLDGIYWNRL AGQAGDGNID AIIHNGAVVN WNDDYEKLQA
PNVDSTISLL KLAIASPAKP RLVYISGGIK TDPQDDRAKT SKKLAGTNGY AQTKYVSEAV
ISEIASRLSA STKQQQNRFS VVKPGLIIGT AKEGVANLDD FLWRITAAAA AMKIYPEESN
NSWLYVSDSS TLSQKITRQL IVQEGEAFVD LSLGLPTSQF WGLVNSELDI SCKPVPWESW
IRSAEEQMQK AGERHVLWPV QHFLGGLGYT VKTCSPAEEG SELPLAIKAN VRYLRRLGFI
QQQSQEPTQV KGDVLRRSHA GAVA
//
