ID A0A151M046_ALLMI Unreviewed; 1718 AA.
AC A0A151M046;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Xin actin-binding repeat-containing protein 2 {ECO:0000313|EMBL:KYO17897.1};
GN Name=XIRP2 {ECO:0000313|EMBL:KYO17897.1};
GN ORFNames=Y1Q_0011548 {ECO:0000313|EMBL:KYO17897.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17897.1};
RN [1] {ECO:0000313|EMBL:KYO17897.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17897.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- DOMAIN: Xin repeats bind F-actin. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
CC -!- SIMILARITY: Belongs to the Xin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00721}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO17897.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03006853; KYO17897.1; -; Genomic_DNA.
DR eggNOG; ENOG502QTAC; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd09442; LIM_Eplin_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR012510; Actin-binding_Xin_repeat.
DR InterPro; IPR030072; XIRP1/XIRP2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR22591; XIN; 1.
DR PANTHER; PTHR22591:SF1; XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF08043; Xin; 8.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS51389; XIN; 10.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00721};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT REPEAT 336..351
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 375..390
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 412..427
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 515..530
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 567..582
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 637..652
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 690..705
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 751..766
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 792..807
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT REPEAT 827..842
FT /note="Xin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00721"
FT DOMAIN 1148..1208
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 177..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1718 AA; 194998 MW; FE2C6404F8163768 CRC64;
MVAPSEGMKP AKLQGDRYTC TTPWISKEVE TERSLHSPTF KNQPGSHSIV SVKESNVRGG
KTVFGKMSSE NGQNKNFEAI IGYRKPVSGF PEEDSNQSGT EPLDFQDALP LKERMALYQA
AVSKVETSSS AINAIEESEA CTVPGGLARV KKQFEKADIA SSKNTFAQYQ YQHKSVQEMT
SRSQLKVSSS SKETERNEVT SKESQLEAFQ TEEVSHLEKA THETTRASNF AQHTEETVVN
AAMDEEISKI STQVLKEQFE RTAQEKADRE PATPAKQIKI ENEYQEIAWP SALTIPKDLY
SKQRNLYELK RLYKHIHPEC MSPEREYLEW DEILKGEVQS MRWVFENQPL DSIKDESPDP
SNIKSIADQE IIAGGDVKYT TWMFETQPID ALGSHSSDSA ENADKIPELA RGDVRTATWM
FETQPLDSMN KIHHDKEQET DETCVKDITG GDVKTVKSEL KEIKGDVKRS IKHFETQPMY
VIRDNLGQML EIKTVHREDI EKVVCGVSME ENIKGGVHKA KWLFETQALD TIKEDSEVTV
NNDNTTHLPP EEIIGGDKVV ATEEEKGDVR HQKWIFETKP LEQIREGKKE FVRTVKLEEI
DKGDVSSCKN IFESSGVNSF GKYHEVKTIR QEEILRGDVK SYRWLFETRP LDQFDESVKK
VQIIKGISSQ EVQSEDEESN TEQTTHIVKG DVKMCRWLFE TQPMELLYDK VQPLDAIKDE
SETTVKLHTI KDESVDINAE KTISVEEITK GDVKNYRMLF ETQPLYAIQD KEGYYHEVTT
VKKEEVIHGD GGDVKANKQL FESQGLKKDT YEPEESEIKI KEEIPQSDVK TTTWLFETTP
FHEFNESKAD EIGDVRMAKY KLMNQEPPEI QKEEIIKGDL GNIMMNLLSK RSTVKREITE
NERGDINMTI YSLLHKKDGN KIHHDEVIGG DVKRTIHNLL SSTMNNEITE RAKIDESERG
NVQFFTTCIE SGALDYLKMF QTGSNEIFTT QKQEEEGEII GGDVEEPENT SCHVHKEEII
KESSYQLKET EKPDVIPGDI KRTIESLEKA INKTNKVLKE AVVQGDLEST LRSLKEAHQS
LKRIDKECVI SNDIQNDGQN QLDTSAEEKI VEHQERKHAE DETVSRGLKV KREVRTEKSE
KLQLQEKEVC TLCQKKAYPM ECLIADKQIF HKSCFRCHHC SSKLSLGNYA SLHGQIYCKP
HFKQLFKSKG NYDEGFGHKQ HKELWNSKDQ SSSMGNVYAE EVNPSKDTPI KSKLSAQIDS
DVSSCTNYVY PETLEDNLKK SSERGKLKIT WPPSKGDASP KKTFSIEDEA KVNKPKWPPD
AFEEEACSIR TDISLGNNKA PYMEKTCSDL RQKEEQKKDD SVDPQQKQPA SFSSVSEREA
ATNINAAKVN EASNKEKDQE NKNVQDKMNE TKGSENKERS GKVVNESDNV VVQSPEKKPN
EKINETGGVE VLQVTNTDDQ TVLGNHKEIN LNNNNNYYTT FSHLSICRQE TSFSAMSKPI
TKFNHANCTE FEYAFEKIAN QPRNAELLDI SESQERDSKD VVSVSLDEQN SKDKDTSECL
VQFNKDATCQ KSCTSNLVLK ETTKITSPFD TELLSSGEEP KHGKHLTTIL SDTVKTPSFP
EKDDTHLDCG LLNSVDIIKN TPSPYSKEYG DYDTDLNDIN ICQEAEIIEV SENAISTSLD
LLSSKCIAVP SSQGDKAKSK QLTIEEQIKR NRCYDENE
//
