ID A0A151M9F7_ALLMI Unreviewed; 519 AA.
AC A0A151M9F7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Signal peptide peptidase-like 2A isoform C {ECO:0000313|EMBL:KYO21156.1};
GN Name=SPPL2A {ECO:0000313|EMBL:KYO21156.1};
GN ORFNames=Y1Q_0001442 {ECO:0000313|EMBL:KYO21156.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO21156.1};
RN [1] {ECO:0000313|EMBL:KYO21156.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO21156.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00004366}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO21156.1}.
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DR EMBL; AKHW03006295; KYO21156.1; -; Genomic_DNA.
DR RefSeq; XP_014461564.1; XM_014606078.2.
DR AlphaFoldDB; A0A151M9F7; -.
DR GeneID; 102571311; -.
DR CTD; 84888; -.
DR eggNOG; KOG2442; Eukaryota.
DR OrthoDB; 907832at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR PANTHER; PTHR12174:SF34; SIGNAL PEPTIDE PEPTIDASE-LIKE 2A; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..519
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007584881"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..142
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
SQ SEQUENCE 519 AA; 57478 MW; AD7980755A8E7B81 CRC64;
MGPAAPLQAL LCGLLLWLAS AQEGILHASG NGIPPVKKDY CILYNPVWTS LANSLDNVTS
NSLENLTSTV LCSYSDVPSG FINDKAVVVM RGNCTYLEKA RIAQKLGAKT LLIASKTALS
PLSGNKTDFK DVTIPVALVR YIDIMDMQTL GNRINVTLYS PPLPEFDYSM FVIFLIAVLT
VALGGYWSGV SEHEDLKAVA SPEDRETRRK KEENVTFTPL TVILFVVICC VMLVLLYFFY
KWLVYVIISV FFLASAMSLY NCLAALLQKI SFGQCRISCC NKSIEVRLIF LAGFCIAAAA
VWVVFRNEDR WAWILQDILG VAFCLNFIKT LKMPNFKSCV ILLGLLLLYD VFFVFITPFI
TKNGASIMVE VAAGPFGNSE KLPVVIRVPR LQFSALTLCG MPFSLLGFGD IIVPGLLVAY
CRRFDVQTRS LSSVYYVSCT LAYAVGMVLT FVVLALMKMG QPALLYLVPC TLITSSVVAW
RRKEMKKFWK GSSYQMMEHL DYTANEENAG TTNEQSGGQ
//
