ID   A0A151MRZ8_ALLMI        Unreviewed;      1200 AA.
AC   A0A151MRZ8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=HEAT repeat-containing protein 3 {ECO:0000313|EMBL:KYO27295.1};
GN   Name=HEATR3 {ECO:0000313|EMBL:KYO27295.1};
GN   ORFNames=Y1Q_0021226 {ECO:0000313|EMBL:KYO27295.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO27295.1};
RN   [1] {ECO:0000313|EMBL:KYO27295.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO27295.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO27295.1}.
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DR   EMBL; AKHW03005226; KYO27295.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151MRZ8; -.
DR   STRING; 8496.A0A151MRZ8; -.
DR   eggNOG; ENOG502QWR9; Eukaryota.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   CDD; cd05402; NT_PAP_TUTase; 1.
DR   CDD; cd13394; Syo1_like; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002058; PAP_assoc.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   PANTHER; PTHR13347:SF1; HEAT REPEAT-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR13347; UNCHARACTERIZED; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF03828; PAP_assoc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT   DOMAIN          725..831
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          887..947
FT                   /note="PAP-associated"
FT                   /evidence="ECO:0000259|Pfam:PF03828"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1045..1200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1059..1178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1200 AA;  131280 MW;  DC65B586A514A076 CRC64;
     MGKSRAKRFA RAPFSPAGTQ AGPGGDEPGQ ADCAAAELLD KLQNPSAEVR EFACASISKL
     LQQKHTIPDF LQRDVVRCLG PMLLDQSLAV RETAAGALRN LSACGGFEVC DDMVTKDIMT
     PLVALLKECS AGLDANQASP KKCKDTNKNY IEDIANEAVN VLWNVCECNG TAVSIFNKEG
     CLDAMLQYLK KFSTNVDLAI SAANCLQAVT EDNPELLSSF SSSAHQVLES VMLSSDTAME
     YILLRTLVAG TGWNIKDTIP SSSLASTVNA MLKIFSESLA IDAGETIIQM KEAETQRLKL
     AAEAETEENM DDMTDKSILN EDVEMEETPK GKARRKNNVL DLLPSDKLEL KQVTALLMAQ
     QTALEIIVNM CSSEDPSDDE WEELSSSDES DLFMENSYDE GSGLLMSPLC LSAEVHAALL
     NYLVPKKILD KTAFPNSVAV DLCAHSPSWK PLIKKLNVVQ CRALTCLHSI LLVADVDCLG
     GSSALQSLSQ HLSQLVFSQS VFPKDTEFLE AVTSALRALL QTMASKNISQ CITPEQLITL
     CEAGIQCSNV SVRVNVVSIL GIAGSVLAKV EDSAETLKMI GKFLLEVAVK DSSLVVAGEA
     LDALFDVFAD GKEAETAAVE IKLLPALKEF QPVFKMRIRK EGKKQYSTDQ FLLLWPGAQS
     AAPALGDGPA ARAQAGPAEP LYTGTPWKKR NYSQGVVGLH EEIIDFYKYM SPRAEEERMR
     MEVVNRIENV IKELWPNADV QIFGSFKTGL YLPTSDIDLV VFGKWETLPL WTLEEALRKH
     NVADENSVKV LDKATVPIIK LTDSFTEVKV DISFNVQNGV KAAQLIKDFI KKYPVLPYLV
     LVLKQFLLQR DLNEVFTGGI GSYSLFLMAV SFLQLHPRED ACIPSANYGV LLIEFFELYG
     RHFNYLKTGI RIKDGGSYVA KDEVQKSMLD GYRPSMLYIE DPLQPGNDVG RSSYGAMQVK
     QAFDYAYVVL SHAVSPIAKY YPNNETESIL GRIIRVTQEV ATYRDWISKQ WGIQSRTESS
     CNGNGVTLIV DTQQLDKCNN NLSEENEALG KSRSKTSETL SKHSSNSSSG PLSSSSSTLS
     SSSDVDSDGT PCKTSKQLSC RQSTTNRVGS QDVSLESSQS GGKMQNSQTA NTSSSMNKSQ
     HGSARLFRSS SNKGFQGPTN SSHGTSVTNK QHQGSKSHNQ YFHGKKRKHK RDAALSDLCR
//