ID A0A151N502_ALLMI Unreviewed; 802 AA.
AC A0A151N502;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|EMBL:KYO31777.1};
GN Name=TPCN1 {ECO:0000313|EMBL:KYO31777.1};
GN ORFNames=Y1Q_0022849 {ECO:0000313|EMBL:KYO31777.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO31777.1};
RN [1] {ECO:0000313|EMBL:KYO31777.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO31777.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO31777.1}.
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DR EMBL; AKHW03004053; KYO31777.1; -; Genomic_DNA.
DR RefSeq; XP_019349269.1; XM_019493724.1.
DR AlphaFoldDB; A0A151N502; -.
DR STRING; 8496.A0A151N502; -.
DR GeneID; 102559623; -.
DR CTD; 53373; -.
DR eggNOG; KOG2301; Eukaryota.
DR OrthoDB; 5403296at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..315
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 426..675
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 768..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 93715 MW; 5A20DDBF98414503 CRC64;
MHLEDCESPV ERSCCLIELD ANDGGNYDIV NDVSSPAAGD CCSRQSSARH NWEMNYQEAA
IYLQEGENND KFFTHPKNAK ALAAYLFAHN HLFYLMELTT ALLLLLLSLC EAPAVPMLRL
GIYVHATLEL FALVVVVFEL SMKMRWLGFH TYIRHKRTMV KTFVLFVQFI EAIVVLVRQT
SHVRVTRALR CIFLVDCRYC GAVRRNLRQI FQSLPPFIDI LALLLFFMVI FGILGFYLFS
PNHSDPYFNT LENSLVNLFV LLTTSNFPDV MMPSYARNPW SCVFFIVYLS IELYFIMNLL
LAVVFDTFND IEKKKFKSLL LHKRTAIQHA YRLLITKQNP SGISFKHLEG LLRFYKPRMC
ARDRYLTFKA LNQSNTPLVS LKDFYNFYEV VGLKWKAKRN REHWFDELPR TAFLIFKGIN
ILVKSQAFQY AMYTVVAVNG IWILVETFML QGGNFLPRDV PWSYIVFLTI YGVELLLKTT
GLGPIEYLSS GWNFFDFLVT LFAFLGLLTL AFNMEPFYFI VVLRPIQLLR LFKLKKRYRN
VLDTIFELFP RMASLGLTLL IFYYCFAIVG MEFFAGVVYP NCCNTSTVAD SYRWLNHTVG
NKTVVEEGYY YLNNFDNVLN SFVTLFELTV VNDWYIIMEG VTSETSHWSR LYFMTFYIVT
MVVMTIIVAF ILEAFVFRMN YMRKNQDSEE DNGIVLEKEI FKEEMVAVTE LYKINCATSE
VAQLQKIIVQ MDKYEQPSML FLGRRSRTKS DLSIKMYEEE IQEWYEEHSR KEEYQQRQEA
LPSSSNNPLK PLGLRQRSQT VI
//
