ID A0A151NAS3_ALLMI Unreviewed; 2358 AA.
AC A0A151NAS3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|EMBL:KYO33910.1};
GN ORFNames=Y1Q_0024524 {ECO:0000313|EMBL:KYO33910.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO33910.1};
RN [1] {ECO:0000313|EMBL:KYO33910.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO33910.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO33910.1}.
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DR EMBL; AKHW03003627; KYO33910.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KYO33910.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1358..1902
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2010..2318
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2326..2358
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2358 AA; 267452 MW; 16B23643D0B628CB CRC64;
MAEPGLGMAS MIPALRDLGS AGPEDYPSVV QKPRQILGQF VDRILTDVDL VALELAKKND
SLPSSVMLLD FIQHIMKSSP LMFVSVSENL PEAECSCIEF TGYESALQDR KAHIGTICTI
FVDVLGSQVD QEYVVSPLYA ALKTEGLEII QEFQHWNQLD ASDTDGWSSS SDEVPEKRKR
LSLSIKNQKK SLVPPVLNSV NMNVKSTLWN AVNKKAESLI FLLEQDTLPA DVLQTVEGIT
VILRLAALCT VHCSPPNSNS VDHKITRSLS NHKRNATLSS DSVVNVQLTW ISSAFIMRIV
KLCRKLLEAA AQIDNLEPVI DRIVKIVDAL FYIQVKSQLD DQILENLCEI LSLPWIYSHL
DDSSFSSDLL VLSQKIAHGF APQIQSHCIF LLSLFPRNIH LDWRKSLYHW ALQSSHEVVR
GSCIKGFPVL LHHVGVKSYS TVPNTLLNQV KDESELVKKA CASITGKLAC CLSGTFKLIP
YLTEPDTEHV KYDILCSSLT VSSTHEDARS VKTFVFKPFL NLLESRVPSS VKLDPDKDVR
VAFSDHIRNI LESLDSEEGF IKELFVSRIK EAYTNAKISR NNELKDTLIL TTGDIGRAAK
GDLVPFALLH LLHCLLSKSA SVAGAAYTEI RALAAAKSIK LQAFFSQYKK PICQFLVESL
HSSQVIAISN TPCQSSELQK QETIHHREVA LNTLSEIANV FDFPDLNRFL SRTLQVLLPD
LAAKASPAAS ELIRTIARQL NVNRREILIN NFKYIFSHLV CSCTKDELER ALHYLRNETE
IELGSLLRQD YQGLHNELLL RMGEHYQQVF NGLSILASFA SHDDPYQGPR DITSPELMAD
YLQPKLLGIL AFFNMQLLSS SVGIEDKKMA LNSLMSLMKL MGPKHISAVR VKMMTTLRTG
LRYKDDFPEL CCRAWNCFVR CLDHAYLGSL LSHVIVALLP LIHIQPKETA AVFYFLIVEN
RDAVQDFLHE IYFLPDHPEL KEIQKVLQEY RKESSKSTDL QTMLQLSMRA IQHGNVDVRI
HALTSLKETL YRNQEKLTKY VTDSETVEPI ISQLVTVLLI GCQDANPQAR LLCGECLGEL
GAVDPGRLDF STSETQGKNF TFVTGVEDPN FAFGLLMELT RAFLAYADNV RAQDSAAYAI
QELLSIYECR ETKIDCSGSR LWRRFPENVQ EILEPHLNTR YKSYQKAVNW SKMKKPIYLS
KLGNNFAEWS ATWAGYLITK VQHELASKVF NCCSIMMKND FKVTIYLLPH ILVYVLLGCS
QEDQQEVYAE IMAVLKHDDL CNRRLQDSAL DLSQLSTQTV FSMLDHLTQW ARHKFQMLIA
EKTTSKSSRD KGDVKSSSEN YGEYQNVTRF LDLIPQDTLA VASFRSKAYT RAVMHFESFI
TEKKQNIQEH LGFLQKLYAA MHEPDGVAGV SAIRKAEPSL KEQILEHESI GLLRDATACY
DRAIQLEPDE IIHYHGVVKS MLGLGQLSTV ITQVNGVLAN RSEWTSELNT YRVEAAWKLS
QWDLLENYLA SDVKSTTWSV RLGQLLLSAK KKNATAFCET LKVVRAEQIV PLSAASFERG
SYQRGYEHII RLHMLCELEH CIGPLFQQSD GDHGKDSLNW CARIEMTQNS FRAKEPILAL
RRALLSLIKR QDYSELVGEC WLQSARVARK AGHHQTAYNA LLNAGESTLS ELYIERAKWL
WSKGEVHQAL IVLQKGVELC FPENKTPSDT KSQLIHGRAM LLVGRFMEET ANFESNAVMK
KYKDVTVFLP EWEDGHFYLA KYYDKLMPMV TDNKMEKQGD LIRYIVHHFG RSLQYGNQFI
YQSMPRMLSL WLDFGAKGYE CEKAGRSERV QMRNDLAKIN KVITEHTNYL APYQFLTAFS
QLISRICHSH DEVFVVLMAI VAKVFLAYPQ QAMWMITAVS KSSYPMRVNR CKEILNKAIH
MKASLGKFIG DATRLTDKLL ELCNKPVDGN SSTLSMSIHF KSLKKLVEEQ TFSEILIPLQ
SVMIPTLPST VGTHSNHDPF PGCWAYIAGF DDTVEILASL QKPKKISLKG SDGKSYIMMC
KPKDDLRKDC RLMEFNSLIN KFLRKDAESR RRELHIRTYA VIPLNDECGI IEWVNNTAGL
RSILIKLYKE KGIYMTGKEL RQHMLPKSAP LSEKLKMFKE ILLPRHPPVF HEWFLRTFPD
PTSWYNSRSA YCRSTAVMSM VGYILGLGDR HGENILFDSL TGECVHVDFN CLFNKGETFE
VPEIVPFRLT HNMVNGMGPM GTEGLFRRAC EVTMRLMRDQ REPLMSVLKT FLHDPLVEWS
KPVKGNTKTQ VNETGEVVNE KAKTHVLDIE QRLQGVIKTR NRIKGLPLSI EGHVHYLIQE
ASDENLLCQM YMGWAPYM
//
