ID   A0A151NIY9_ALLMI        Unreviewed;       858 AA.
AC   A0A151NIY9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Calcium-activated chloride channel regulator 2 {ECO:0000313|EMBL:KYO36766.1};
GN   Name=CLCA2 {ECO:0000313|EMBL:KYO36766.1};
GN   ORFNames=Y1Q_0020820 {ECO:0000313|EMBL:KYO36766.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36766.1};
RN   [1] {ECO:0000313|EMBL:KYO36766.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36766.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- SIMILARITY: Belongs to the CLCR family.
CC       {ECO:0000256|ARBA:ARBA00006398}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO36766.1}.
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DR   EMBL; AKHW03002907; KYO36766.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151NIY9; -.
DR   STRING; 8496.A0A151NIY9; -.
DR   eggNOG; ENOG502RIMV; Eukaryota.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR004727; CLCA_chordata.
DR   InterPro; IPR013642; CLCA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; TIGR00868; hCaCC; 1.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF66; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 2; 1.
DR   Pfam; PF08434; CLCA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00023049};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..858
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007586099"
FT   DOMAIN          313..484
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   858 AA;  94659 MW;  0DF1B5F1CE78886B CRC64;
     MSRGRGAGAA LRPLALLALL ALALAGGGDA AVLLQDGAYD GLLLAVHPRV PEDPKLLASI
     QDMITEASFY LFSATKNRFY FRNAKILIPP TWKANNYEKP KQESYDKADV IVAAPYWKHG
     DDPYTLQYGE CGKMGKYIHF TPTFLLNDKL IAVYGSRGRV FVHEWAHLRW GVFDEYDSDR
     PFYITGQNRV EVTRCSSNLT GIYVCEKKSC TEGNCVINQL TGLFIEGCAF IHERNQTAAA
     SIMYMQSLSS VAEFCDESNH NREAPNMQNR MCDYRSTWEV IMKSMDFKNN PPLNTTSLLP
     PPTFSLLQKR DRVVCLVLDV SNSKDGTNWI NQLHQAAELY LLQIVEENSY VGIVTFSHSG
     EIKTQLRQIV SNDIRTQLAS FLPTAPTSEG TNVCAGLQLA FEVIRKHDGS IYGSEIILVT
     DGEDSGVKKC FSDVINSGSV IHTIVLGQSA AKEIEQFSRE TGGLNFFVSD RLNSNDLIDA
     FCGILSGSGD TFNQSIQIES TGESTQGYKQ FRRTVTIDST VGRDTFFVVT WQTTEPPKIT
     LLDPHGKNYT NENFSIDIIF HIARLQIPGI AEAGKWTYTL TNTHLSPQVL TITVTSRAAN
     STIPAITVKA HMNRDTNYYP SPMVAYAQVG QGLSPVLGAN VTAIIEPENG DPIILELFDN
     GAGSDVVRND GVYSKYLFSF RGNGKYNLKV RVQVSEIIKL HAATPWSHAL YIPGYVENGT
     IQMNGPRPSV TSNDDIQIKV GGFSRTISGG YFTVSEVPTS PDTDVFPPCK ITDLSAKTED
     DKVILSWTAP GGDLDQGQAA TYEIRTSESP LELRDNFDEA TVVNTSSLTP HYAGYKEIFS
     FKPAAFATRN TTIIYVAA
//