ID A0A151NLN2_ALLMI Unreviewed; 1190 AA.
AC A0A151NLN2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=Y1Q_0022021 {ECO:0000313|EMBL:KYO37732.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO37732.1};
RN [1] {ECO:0000313|EMBL:KYO37732.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO37732.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO37732.1}.
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DR EMBL; AKHW03002600; KYO37732.1; -; Genomic_DNA.
DR RefSeq; XP_014461051.2; XM_014605565.2.
DR RefSeq; XP_019343949.1; XM_019488404.1.
DR AlphaFoldDB; A0A151NLN2; -.
DR STRING; 8496.A0A151NLN2; -.
DR GeneID; 102563002; -.
DR KEGG; amj:102563002; -.
DR CTD; 2911; -.
DR eggNOG; KOG1056; Eukaryota.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15449; 7tmC_mGluR1; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001256; GPCR_3_mGluR1.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01051; MTABOTROPC1R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 613..875
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 903..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 133032 MW; C850880D33E1922C CRC64;
MCRQEKPMKF VTWIWMTSCN KMIGVLLVFF PAIFLEIDIL PRNTGRKILL SGASSQRSVA
RMDGDVIIGA LFSVHHQPPA EKVPERKCGE IREQYGIQRV EAMFHTLDKI NSDPVLLPNI
TLGSEIRDSC WHSSVALEQS IEFIRDSLIS IRDDKDGINR CISEAQSQHQ ARVKKPIAGV
IGPGSSSVAI QVQNLLQLFD IPQIAYSATS IDLSDKTLYK YFLRVVPSDT LQARAMLDIV
KRYNWTYVSA VHTEGNYGES GMEAFKELAA QEGLCIAHSD KIYSNAGEKS FDRLLRKLRE
RLPKARVVVC FCEGMTVRGI LIAMRRLGVL GELQLIGSDG WADRDEVIEG YEPEANGGIT
IKLQSPEVLS FDDYYLKLRL DTNTRNPWFP EFWQHRFQCR IPGHPLENPN FQKNCTGNET
LEDSYVQDSK MGFVINAIYA MAHGLQNMHL SLCPGHVGLC DAMKPIDGSK LLEFLIKSSF
IGISGEEIWF DEKGDAPGRY DIMNLQYIKP NHYDYVLIGT WHEGVLNIDD YRIQMNRSGI
VRSVCSEPCL KGQIKVIRKG EVSCCWICTP CKENEFVQDE FTCKACDLGW WPNVVLTGCE
PIPVKYLQWS NIESIVAVVF SCLGILVTMF VTLIFVLYRD TPVVKSSSRE LCYIILAGIF
MGYICPFTLI AKPTITSCYL QRLLVGLSSA MCYSALVTKT NRIARILAGS KKKICTRKPR
FMSAWAQVLI ASILISVQLT LVVTLIIMEP PMPILSYPSI KEVYLICNTS NLGVVAPVGY
NGLLIMSCTY YAFKTRNVPA NFNEAKYIAF TMYTTCIIWL AFVPIYFGSN YKIITTCFAV
SLSVTVALGC MFTPKMYIII AKPERNVRSA FTTSDVVRMH VGDGKAPCRS NAFLSIFRRK
KPGVGNPNSN GKSVSWSEPG GRQVPKGQHM WHRLSVHVKS QESGCNQTAV IKPLTKSYHG
QSKSMTFSDI SSKTLYNVVE EEENEPARFN QPSSPSMVVH RRVMTTPPLQ AMAEETHLFL
PEQTPKSLPP QQKSIMEQLQ GVVNKFATGI PDFNSVIPVP NAGNGVRPLY PPPLLLQQQA
LPLQMASFSE EPVSPPAEEA ESEKLKLIQG YVYERPDNPE DEEEEKEQAT SKLTLEDSPA
LTPPSPFRDS VASGSSVPSS PVSESVLCTP PDVTYASVIL RDYKQSSSTL
//
