ID A0A151NP70_ALLMI Unreviewed; 530 AA.
AC A0A151NP70;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=HMG box-containing protein 1 {ECO:0000256|ARBA:ARBA00017229};
DE AltName: Full=HMG box transcription factor 1 {ECO:0000256|ARBA:ARBA00030708};
DE AltName: Full=High mobility group box transcription factor 1 {ECO:0000256|ARBA:ARBA00030026};
GN Name=HBP1 {ECO:0000313|EMBL:KYO38621.1};
GN ORFNames=Y1Q_0023345 {ECO:0000313|EMBL:KYO38621.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38621.1};
RN [1] {ECO:0000313|EMBL:KYO38621.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38621.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Transcriptional repressor that binds to the promoter region
CC of target genes. Plays a role in the regulation of the cell cycle and
CC of the Wnt pathway. Binds preferentially to the sequence 5'-
CC TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by
CC interaction with RB1. Disrupts the interaction between DNA and TCF4.
CC {ECO:0000256|ARBA:ARBA00025095}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO38621.1}.
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DR EMBL; AKHW03002440; KYO38621.1; -; Genomic_DNA.
DR RefSeq; XP_006257874.2; XM_006257812.2.
DR AlphaFoldDB; A0A151NP70; -.
DR STRING; 8496.A0A151NP70; -.
DR GeneID; 102574562; -.
DR KEGG; amj:102574562; -.
DR CTD; 26959; -.
DR eggNOG; ENOG502QR1P; Eukaryota.
DR OrthoDB; 2882425at2759; -.
DR PhylomeDB; A0A151NP70; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd21988; HMG-box_HBP1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR003652; Ataxin_AXH_dom.
DR InterPro; IPR036096; Ataxin_AXH_dom_sf.
DR InterPro; IPR039655; HBP1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR15499; HMG BOX-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR15499:SF3; HMG BOX-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08517; AXH; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00536; AXH; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF102031; AXH domain; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51148; AXH; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 216..358
FT /note="AXH"
FT /evidence="ECO:0000259|PROSITE:PS51148"
FT DOMAIN 450..518
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 450..518
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 162..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59244 MW; 9658482666B48B3D CRC64;
MATGLSDNLE HPNMVWEVKT NQRPNAVQKL LLVVDKRTSG MNESLELLKC NENLPSSPGY
ASCDDEHMEL DDLPELQAVQ TDSTPNALFQ LSADVSHQEY SRPSWNQHTS NENSESAYSC
ENGVNWLTEL ANIATSPQSP LMQCSFYNRS SPVHIIATSK SLHSYARPPP GSSESDPGFS
KHHLDETPVR HERANSESES GIFCMSSLSD DDDLGWCHSW PSTVWHCFLK GTRLCFHKGR
NKEWQDVEDF ARSEGCSNEE ELPMRTYKGY GSDGLKLISH EESVSFGESV LKLTFDPGTV
EDGLLTVECR LDHPFYIKSK GWSSFYPSLT VVQHGIPCYE IHIGDLCLPP GHPDAINFDD
SGVFDTFKSY DFTPMDSSAV YVLSSMARQR RASLSCGGSG SQDSERSECS KNCVSSGSSQ
LSSNSLYSKA GKSHSSGTAS TVSATSPNKC KRPMNAFMLF AKKYRVEYTQ MYPGKDNRAI
SVILGDRWKK MKNEERRMYT LEAKALAEEQ KRLNPDCWKR KRTNSGSQQH
//
