ID A0A151NSY5_ALLMI Unreviewed; 2598 AA.
AC A0A151NSY5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Filamin-B {ECO:0000313|EMBL:KYO39908.1};
GN Name=FLNB {ECO:0000313|EMBL:KYO39908.1};
GN ORFNames=Y1Q_0013035 {ECO:0000313|EMBL:KYO39908.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO39908.1};
RN [1] {ECO:0000313|EMBL:KYO39908.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO39908.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO39908.1}.
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DR EMBL; AKHW03002161; KYO39908.1; -; Genomic_DNA.
DR STRING; 8496.A0A151NSY5; -.
DR eggNOG; KOG0518; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 23.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 23.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 23.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 29..135
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 152..255
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 263..361
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 363..461
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 462..558
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 559..651
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 655..751
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 752..854
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 855..953
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 954..1048
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1049..1141
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1142..1236
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1237..1336
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1337..1429
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1430..1525
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1526..1622
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1635..1726
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1741..1810
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1810..1902
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1900..1989
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1992..2084
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2186..2267
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2269..2362
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2366..2458
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2503..2597
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2146..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2598 AA; 277143 MW; 1A288AFB4522F74C CRC64;
MSSQEAPGEE AEEMPATEKD LAEDAPWKKI QQNTFTRWCN EHLKGANKRI GDLQRDLSDG
LRLIALLEVL SQKRMLRKFH ARPNFRQMKL ENVSVALEFL DRERIKLVSI DSKAIVDGNL
KLILGLVWTL ILHYSISMPM WEDEDDEDAK KQTPKQRLLG WIQNKVPQLP ITNFHRDWQD
GKALGALVDN CAPGLCPDWE TWDPNQPVEN AREAMQQADD WLGVPQVIAP EEIVDPNVDE
HSVMTYLSQF PKAKLKPGAP LRSKQLNPRK ALAYGPGIEP QGNRVLQPAH FTVETLEAGM
GEVLVYVEDP EGHTEEAKVV ANNDKKRTYS VSYVPKVAGL HKVTVLFAGQ NINKSPFGVN
VGLALGDASK VTARGPGLEP VGNVAHKPTY FDIYTAGAGA GDVAVTIVDP QGRRDTVEVV
LEDKGDSTFR CTYRPVLEGP HTVHVSFAGA PVPRSPFPVH VAEACNPNAC RATGRGLQPK
GVRVKEVADF KVFTKGAGSG ELKVVVKGPK GIEEPVKVRE VGEGVYECEY YPVLSGKYSV
TITWGGYAIP RSPFEVQVAP EPGLQKVRAW GPGLETGMVG KSADFVVEAI GTEVGTLGFS
IEGPSQAKIE CDDKGDGSCD VRYWPTEPGE YAVHVICDDE DIKDSPFIAH ILPAAPNCFP
EKVKAFGPGL EPTGCIVDRP AEFTIDARGA GKAELKIYAQ DAEGFPIDIK VKDNGDGTYR
CVYVPTKPIK HTIILAWGGV NIPKSPFRVS VGEGSHPEKV RVYGPGVEKT GLKASEPTYF
TVDCSEAGQG DVSIGIKCAP GVVGPAEADI DFDIIKNDND TFTVKYTPPG AGLYTIMVLF
ANQEIPSSPF RIKVDPSHDA SKVKAEGPGL SRTGVEVGLP THFTVHTKGA GKAKLDVQFS
GPTKGPATRD VEIIDNHDYS YTVKYTALQQ GNLSVVVTYG GDPVPKSPFT VGVAPPLDLS
KVKVQGLNSK VDVGRDQEFT VNTRGAGGQG QLDVRITSPS RRPIPCKVET GTGDARPVQY
MPPEEGPYKV EVAYDGHPVP GSPFAVEAVM PPDPSKVCAY GPGLKGGFVG KPAPFTIDTK
GAGTGGLGLT VEGPCEAKIE CQDNGDGSCS VSYLPTEPGE YAINILFAEA HIPGSPFKAD
IQPLFDPSKV TASGPGLERG RAGETATFLV DCSKAGEAEL TIEIISDAGV KAEVLIQNNR
DGTYTITYTP ACPGAYTITI KYGGLPVPKF PARLTVDPAV DTSPIKVYGP GVEPRGVLRE
VTTEFTVDAR ALTKTGGSHI KARVVNPSGA KTDTYITDNA DGTYRVQYTA YEDGVHRVEV
TYDDVPVPKS PFRVAVAEGC DPSRVRAYGP GLEGGLVNKA NRFTVETRGA GTGGLGLAIE
GPSEAKMSCK DNKDGSCSVE YIPFTPGDYD VNITFGGRPI PGSPFQVPVK DVVDPSKVKC
TGPGLGAGVR ARVPQTFTVD CSKAGRAPLE VVVLGPSGLA EPVEVRDNGD GTHKVNYTPA
TDGPYTVAVK YAGQEVPRSP FKIKALPAHD ASKVRASGPG LSAAGVPASL PVEFTIDARD
AGEGLLTVQI LDPEGKPKKA NIRDNGDGTY TVSYVPDLTG RYTITIKYGG DEIPFSPFRT
HALPSGDASK CLVTVSIGGH GLGACLGPTI QIGEETVITV DAKAAGKGKV TCKVSTPDGA
ELDVDVVENH DGTFDIYYTA PEPGKYVITI RFGGEHIPNS PFHVLATDEP VVPATESLRP
FNLVIPFTVQ KGEITGEVRM PSGKKGRPRI TDNKDGTVTV QYSPTEKGLH EMDIKYDGNH
IPGSPLQFYV DAVNARHVSA YGPGLSHGVV NKPATFTIIT KDAGEGGLSL AVEGPSKAEI
TCQDNKDGTC TVSYLPTAPG DYSIIVRFDD KHIPGSPFTA KITGDDSMRT SQLNVGTSTD
VSLKITETDL SMLTASIRAP SGTEEPCLLK RLPNRHIGIS FTPKEVGEHV VSVRKSGKHV
TNSPFKIVVG PSEIGDASRV KVWGAGLAEG RTFQLSDFIV DTRSAGYGGL GLSIEGPSKV
DINCEDMEDG TCKVTYCPTE PGTYVINIKF ADKHVPGSPF MVKVTGEGRM KESITRRRQA
PSIATIGSTC DLNLKIPGNW FQMVSAQERL TRTFTRSSHT YTRTERTEIS KTRGGETTRE
VRVEESTQVG GDPFPSVFGG FLGREGLGAF STIARSQEAE FSIWTREAGA GGLSIAVEGP
SKAEIAFEDR KDGSCGVSYV VQEAGDYEVS IKFNDEHIPD SPFVVPVASL SDDARRLTVT
SLQETGLKVN QPASFAVQLN GARGLIEAKV HTPSGGVQEC CVSELDSDKS AIRFIPRENG
VHSIDVKFNG RHIPGSPFKI RVGEQSQAGD PGLVTAYGPG LEGGTTGVCS EFFVNTVNAG
AGALSVTIDG PSKVQLDCQE CPEGHRVTYT PMAPGSYLIS IKYSGPHHIV GSPFKAKVTG
PRLSGGHSLH ETSTVLVETV MKSAGAAVAV AAARGPGFPA MPKFSSDASK VVARGPGLSK
AFVGQKNTFT VDCSKAGSNM LMVGVHGPKT PCEEVYVKHV GGRVYNVTYT VKETGDYVLI
LRWGDENVPG SPFRVSVP
//
