ID A0A151P0J4_ALLMI Unreviewed; 2259 AA.
AC A0A151P0J4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ATP-binding cassette sub-family A member 1 isoform B {ECO:0000313|EMBL:KYO42636.1};
GN Name=ABCA1 {ECO:0000313|EMBL:KYO42636.1};
GN ORFNames=Y1Q_0000303 {ECO:0000313|EMBL:KYO42636.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO42636.1};
RN [1] {ECO:0000313|EMBL:KYO42636.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO42636.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO42636.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03001382; KYO42636.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF49; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA7; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:KYO42636.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1652..1674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1694..1720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1732..1751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1763..1787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1850..1867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 894..1125
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1909..2141
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1130..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2221..2243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2222..2243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2259 AA; 248393 MW; 07D94FD9B2D6CF51 CRC64;
MGFGTQLGLL LWKNFTYRRR QTIQLAIELL WPLFLFFILI SVRQSHPPFE QHECHFPSKA
LPSAGTLPWI QGIICNANNP CFQYPTAGEM PGTVGNFNGS IISRLFADAR RVLLHPDSRQ
ALSHLAQLLP ALRRLRGDEA QWTALPVRDY LKANETFSEF LRANASAPPG LADQLLGARL
SPRILSLAAS GLSLQDVVCN ASVLAEVLVV PGAGALGTLQ PWLCSLPAPT LQALERSFLS
QVDVTRVLAE WLGSGADDVA GTVEALVAVL RGAETLAEEV SAMHSFADLR RELGALGGST
SPQGAFAALS RLACGHANST GLRIPSLNWY EDSDVRAFLS RNSSEPRAVA LDNGTNPYCK
ELIRSLESNP LSRILWRSIK PLFVGKILYT PPSPGARRIM AEVNRTFQEL AVLREVGGAW
QELGPRLYTF LNSSLEMQAL QELLGAPATT PLLAQRLAGT SWNLSTVRDY LAGPRGWRDT
YAELDQVLGT LSQFIECVSL DKIEAVGSEE ELVSRALELL EARQFWAGVV FLPPTGNATG
DPAPHIRYKI RMDIDDVTRT NKIKDRFWDP GPAADPFSDL RYVWGGFVYV QDLVEQAVTR
VLTGTTRRTG LYMQQMPYPC YVDDVFLRVL NRSLPLFMVL AWIYSVAMMV KGVVHEKEAR
LKETMRIMGL SRGTLWLSWF LSSLLPFLLS SGLLVLILKL GDILPYSDPA VVFLFLVAFA
VATIAQCFLL STFFSRANLA SACGGIIYFS CYLPYVLCVA WRDRVTFPLR VLVSLLSPVA
FGFGCEYFSL YEEQGVGIQW YNLNASPVQG DPYNFATSVA LLLGDACLYG LATWYIEAVF
PGQYGIPKPW NFPFLRSYWF GESSLEGQVP HPTSAPSSAK VLVEEPPAGL EPGVSICNLV
KIYRGSSRAA VNGLSLDFFE GQITSFLGHN GAGKTTTMSI LTGLLPPSAG TAYILGRDVR
SEMDAIRSTM GVCPQHNILF DILTVEEHVW FYGRLKGLSG RQVAAETEQL LRDVGLPHKR
REPTRCLSGG MQRKLSVAIA FVGGSRVVVL DEPTAGVDPY SRRGIWDLLL KYRQGRTIVL
STHYMDEAEL LGDRIAIIAQ GRLCCCGSPL FLKTHLGTGY YLTLVKREPG TRERPAPQGS
SGSITIAGKK DDSDSEHSCD TGLGSEQCSE SSTVDVPQLS ALVQKLVPGS RLVEDIGHEL
LYVLPSSGAK DGSFGELFRE LDTRLGELGV SGYGVSDTTL EEIFLKVAED TGADTSRSGP
PGAPQRVRAT PASADTLRAL SEDGDLEAAE ADLAEEPQET DALRGPEDRG SHQLTGWALT
RQQLRALFLK RLLYARRSTR GFLAQIILPA VFVCMALLFS LLVPPFGEYP PLRLEPWMYE
QQFTFFSDDA PGDPDSACLL GALLAEPGFG TKCMKDALEP RELCPPALQG EGFHTPAVPP
ALEEVFRSGN WTPDDPSPPC KCSSPQSRKM LPECPEAAGG LPPPQVQRGT GDILQNLTGR
NISDYLVKTY PKIIRQGLRN KKWVNEQRYG GISLGARSLQ GLPLAEEVTN AVREIRAVLN
VTEGSPLDRL LGNLSNFIAG LDTHDNVKVW FNNKGWHAMV SFLNVVSNGV LRANLPPGAD
PTRYGITAIN HPLNFTKEQL SEAALMATSV DVLVSICVMF AMSFVPASFV LFLIEERVSQ
AKHLQFVSGM TPGVYWLGNF AWDMCNYLVP AALVVLIFLG FQQKSYVSAD NLPSLVLLLL
LYGWSITPLM YPASFLFSVP STAYVALTCI NLFIGINGSM ATFVLELFTD KKLNDINRVL
KKVFLVFPHF CLGRGLIDMV KNQAMADAFE RFGDKRFVSP LCWDLAGKNM FAMALQGIVF
FLVTLLVQHR FFLTLRPFAV KLPALGEEDE DVAREREKVL SGARQGDVLV LENLTKVYRR
RKVPAVDRLC LGIPPGECFG LLGVNGAGKT STFKMLTGDT EVTLGDARLK GHSVLCDMQA
MHQSMGYCPQ FDAINDLLTG REHLEFYSRL RGVPEDEAPR VAQWGISKLG LAPYADRPAG
GYSGGNKRKL STAIALIGCP PVIFLDEPTT GMDPGARRFL WNCVLSVIKE GRSVVLTSHS
MEECEALCTR MAIMVNGRFR CLGSGQHLKN RFGDGYTIVL RVGGSSPDLQ PLEQFMQETF
PTIALRERHR GTLQYQLPAR RNSLAHVFST LAAQRARYCL EDYSVSQTTL DQVFLHFAKD
QSDEGTASQG PPAPGSVSPS PWTRITRFLQ DERYQESRV
//
