ID A0A151P2Y6_ALLMI Unreviewed; 3362 AA.
AC A0A151P2Y6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=Y1Q_0013497 {ECO:0000313|EMBL:KYO43432.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO43432.1};
RN [1] {ECO:0000313|EMBL:KYO43432.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO43432.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO43432.1}.
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DR EMBL; AKHW03001146; KYO43432.1; -; Genomic_DNA.
DR STRING; 8496.A0A151P2Y6; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 714..858
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 995..1148
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1321..1469
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1930..2020
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2166..2214
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3362 AA; 384636 MW; 4A23F3044E5AA4BA CRC64;
MGIWPLKLAL SIEAKAWKML LCRYLNEEYK KKMTDIISFI TEYLKKLSRP IRDLDDVRFA
MEALSNIRDK EIQIDMTLGP IEEAYTILNR FEVEVTKEES EGVDTLRYSF NKLLTKAVSV
QDELVQVQPK FKSSLLESVA VFREDVSNFE TSYETEGPMV PNIPPQEASN RLQLYQANFD
ELWRKFVTYS SGEQLFGLPV TDYEVLHKIR CRKLPKGLKN WQAFLDLKKR IDNFSESCPL
LEMMTNKAMK QRHWNRIAET TEHPFDVESD SFSLRNIMEA PLLKHKEDIE DICISAIKEK
DIEAKLSQVV ESWGGQSLSF SAFKGRGELL LKGTESSEII TMMEDSLMIL GSLLSNRYNT
PFKKEIQNWV YKLTTSSDII EEWLVVQNLW VYLEAVFVGG DIAKQLPQEA KRFQNIDKSW
IKIMQRAHEN PNVINCCVGD ETMGQLLPHL HEQLEVCQKS LTGYEKFLKN IIINSLHKPH
LPSISDNVNE VQFHVKDYDR ILAVISREGE KIPLDTPVNA KGPVELWLLD LLRVQQSSLH
GIIRAAYYQI SDSGYQLLNF LNHFPAQVGL LGIQMMWTHD SEEALRSAKD DRKIMQVTNQ
RFLDILNTLI GQTTHDLSKY DRVKYETLVT IHVHQRDIFD DLVKMHIKSV SDFEWLKQCR
FYFKEDFDQV LVSITNVDFV YQNEFLGCTD RLVITPLTDR CYITLAQALG MNMGGAPAGP
AGTGKTETTK DMGKALGKYV VVFNCSDQMD FRGLGRIFKG LAQSGSWGCF DEFNRIELPV
LSVAAQQIYI ILTARKERKK QFIFSDGDCV DLNPEFGIFL TMNPGYAGRQ ELPENLKIQF
RTVSMMVPDR QIIMRVKLAS CGFIDNVVLA QKFFVLYKLC EEQLTKQVHY DFGLRNILSV
LRTLGAQKRA RPDDSELSTV MRGLRDMNLS KLVDEDEPLF LSLINDLFPG LLLDSNTYVE
LQAAVTNQVE EAGLINHPPW NLKLVQLYET SKVRHGLMTL GPSGSGKTTV ITILMRAMTE
CGHPHREMRM NPKAITAPQM FGKLDTATND WTDGIFSTLW RKTLKAKKGE NIFLILDGPV
DAIWIENLNS VLDDNKTLTL ANGDRIPMAP TCKLLFEVHN IENASPATVS RMGMVYISSS
ALSWRPILQA WLKKRSSQEA DVLQNLYDRI FEPTYTYMKL NLNPKVELLE CNYIMQSIHL
LEGLIPSKEE GGISTVFHLH KLFSFGLMWS LGALLELDSR DKLEAFIRAH DNKLDLPEIP
VETNQTMYEF YVTDYGDWEH WSKRVQEYVY PTDSVPEYAS ILVPNVDNVR TQFLIDTIAK
QHKAVLLTGE QGTAKSVMIK AYLKKYDPEQ HLSKCLNFSS ATEPFMFQRT IESYVDKRMG
STYGPPGGRK MTVFVDDINM PIINEWGDQI TNEIVRQMME MEGMYSLDKP GDFTTIVDVQ
LIAAMIHPGG GRNDIPQRLK RQFSIFNCTL PSNASIDKIF GIIGSGYFHP CRKFSPEICD
VIKKLVPTGR ILWQWTKTKM LPTPSKFHYI FNLRDLSRIW QGMLTIKAEE CNNITTLMAL
FKHECTRVIA DRFITDEDVA WFDKTIFRAV EECMGAGLES VLQNEPYFVD FLREMPEPTG
EEPEDFVFEA PKMYEEIPTF EFLCERLQAY QKSYNEYIRG SFLDLVFFKD AMTHLVKISR
IIRTACGNAL LVGVGGSGKQ SLSRLASFIA GYRIFQITLT RSYNVSNLTD DLKLLYKVAG
AEGKGITFIF TDNEIKDEAF LEYLNNLLSS GEISNLFARD ELDEITQGLI SVMKKELPRN
PPTYDNLYEY FISRAKKNLH VVLCFSPVGE KFRARSLKFP GLISGCTMDW FNRWPKEALV
AVASYFLSEF NMVCSTSVKA RVVETMGLFH DIVSESCDNY FQRYRRRAHV TPKSYLSFIN
GYKEVYADKL ENINEQAERM QIGLSKLMEA SESVAKLSQE LAVKEKELAA ASIKADKVLA
EVTVSAEAAA KVKNEVQGVK DKAQKIVDEI DSEKVKAETK LEAARPALED AEAALNTIKP
VDIATVRKLA KPPHLIMRIM DCVLLLFQKK IDPVTLDPEK PCCKPSWGES LKLMSGPFLQ
SLQQFPKDSI NEETVELLQP YFNMEDYTLE HGKKVCGNVA GLLSWTQAMA IFYSINREVL
PLKANLAKQE GRLKVANAEL AQAQEALDEK QAELDKVQAK FDAAMKEKMD LLNDAEMCRR
KMQAASALID GLSGEKVRWT QQSKEFRAQI NRLVGDVLLC TGFLSYCGPF NQSFRNLLLK
DLWEAEMRIR KIPFTENLNL ISMLVDPPTI SEWNLQGLPG DELSIQNGII VTKATRYPLL
IDPQTQGKTW IKKKEQGNEL QVTTLNHKYF RTHLEDSLSL GRSLVIEDIG EELDPALDNI
LEKNFIKSGS SYKVKVGDKE IDVMNTFKLY ITTKLPNPAF TPEINAKTSV IDFTVTMKGL
ENQLLRRVIL TEKQELEAER IKLMEDVTFN KRKMKELEDN LLYKLSATKG SLVDDESLIG
VLRTTKQTAA EVAEKLYVAG ETQVKINTAQ EEYRPAATRG SILYFLITEM SMVNNMYQTS
LAQFLKLFDQ SMAKSEKSPL PQKRISNIIE YLTYETYMYS VRGLYENHKF LFTLLLTLKI
DLQRGHVKTR EFQALIRGGA ALDLKACPPK PFRWILDMTW LNLVELSKLP QFSEIMNQIL
RNEKGWKSWF DKDAPEEEVI PDGYNDSLDT CRKLLLIRSW CPDRTLSQAR KYIADSLDEK
YTEPVILQLE KTWEESDTRT PLICFLSMGS DPTIQIDSLA RKLKLECRTI SMGQGQEVHA
RKLTQMSMQQ GGWVLLQNCH LGLDFMEELL ETLLTAEIPD ESFRVWITTE PHLKFPITLL
QISIKFTNEP PQGVRAGLKR TFSGINQDLL DVSNLPMWKP LLYTVAFLHS TVQERRKFGP
LGWNIPYEFN SADFTASVQF IQNHLDECDI KKGISWSTVR YMIGEVQYGG RVTDDFDKRL
LNCFARVWFS EKMFESAFSF YTGYKIPVCK TLEQYQEYIQ SLPAMDSPEV FGLHPNADIT
YQSNTAADVL DTITNIQPKE SGGGAGETRE AIVYRLAEDM LDKLPSDYIP HEVKNRLIKM
GHLNSMNIFL RQEIDRMQKV ISILRNSLND LKLAIEGTII MSESLRDALD NMYDARIPQL
WKRVSWDSST LGFWFTELLE RNTQFSTWIF EGRPPVFWMT GFFNPQGFLT AMRQEATRAH
KGWALDTVTI HNEVLKQAKE EITTPPAEGV YIYGLYLDGA GWDRRNSKLT ESAPKILFTP
LPVVHIFAIN TTGPKDPKLY VCPVYKKPRR TDLTYITVIY LRTIVSPDHW ILRGVALLCD
IK
//
