ID A0A151PFL6_ALLMI Unreviewed; 868 AA.
AC A0A151PFL6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL5 {ECO:0000313|EMBL:KYO47798.1};
GN ORFNames=Y1Q_0019856 {ECO:0000313|EMBL:KYO47798.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO47798.1};
RN [1] {ECO:0000313|EMBL:KYO47798.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO47798.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO47798.1}.
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DR EMBL; AKHW03000416; KYO47798.1; -; Genomic_DNA.
DR RefSeq; XP_014451343.1; XM_014595857.2.
DR AlphaFoldDB; A0A151PFL6; -.
DR GeneID; 106736924; -.
DR CTD; 114882; -.
DR OrthoDB; 1018068at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13286; PH_OPR5_ORP8; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF218; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 8; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT TRANSMEM 849..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..242
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 38..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 805..832
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 54..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 99103 MW; 33AA3F463A40C887 CRC64;
MKEEGPLRRR FSSCAGISST VFPLRTDGRK LVRNASFGGY NELSPTLPGF DKGKDDGSQS
KEDSVHSMSK SKSESKLYNG SEKDISSASS KLTKKESLKV QKKNYREEKK RATKELLSTI
TDPSVIVMAD WLKIRGTLKS WTKLWCVLKP GVLLIYKTPK NGQWVGTVLL NACELIERPS
KKDGFCFKLF HPLEQSIWAV KGPKGEAVGS ITQPLPSSYL IIRAASESDG RCWMDALELA
LKCSGLLKRT MIREGKEHDL NVPAENTHVS FYGLLRANNL HSAENFPLND SEIERQHFKD
QDLYSDKSDK ENDHDHDESD NDGLGKSEES DSDTSERQDD SYIDPEPIDD LKETTYLEEA
HEELGEAGEA SQTEVVSEEN KSLIWTLLKQ VRPGMDLSKV VLPTFILEPR SFLDKLSDYY
YHADFLSEAA LEENAYNRLK KVVKWYLSGF YKKPQGLKKP YNPILGETFR CMWIHPRTNS
KTFYIAEQVS HHPPVSAFYV SNRKDGFCLS GSILAKSKFY GNSLSAILEG EGRLMFLNRG
EDYVMTMPYA HCKGILYGTM TLELGGTVNI TCEKTGYSAT IEFRLKPFLG NSDSVNQISG
KIKLGKEVLA ILEGHWDSEV FISDKKTEVS ETFWNPTDEI RQRRLTRYTV KFEEQNDFES
EKLWQQVTRA INNKDQTEAT QEKYVLEEAQ RRAAKERKLK GEEWICKLFE QDLVAGEWHY
RYADTRPWDL LNDMIQFEKD GAIQTKVRHR TPMVSVPKIK RKLASQQKKG ECGFSSPEPD
NQDSSGSEAQ LLKHNTRIRK KGTDLGELQS AIESIKETQE DIKRDIMALR NRVTSNLPPL
DNNFLQLKHY VFILLLVLLQ FIVNFLFK
//
