ID A0A151WMD5_9HYME Unreviewed; 2660 AA.
AC A0A151WMD5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KYQ49003.1};
DE Flags: Fragment;
GN ORFNames=ALC60_12059 {ECO:0000313|EMBL:KYQ49003.1};
OS Trachymyrmex zeteki.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=64791 {ECO:0000313|EMBL:KYQ49003.1, ECO:0000313|Proteomes:UP000075809};
RN [1] {ECO:0000313|EMBL:KYQ49003.1, ECO:0000313|Proteomes:UP000075809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tzet28-1 {ECO:0000313|EMBL:KYQ49003.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYQ49003.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex zeteki WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ982944; KYQ49003.1; -; Genomic_DNA.
DR STRING; 64791.A0A151WMD5; -.
DR Proteomes; UP000075809; Unassembled WGS sequence.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000075809}.
FT DOMAIN 1161..1356
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1496..1654
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2332..2366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2405..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2604..2660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2604..2622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2623..2660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KYQ49003.1"
SQ SEQUENCE 2660 AA; 302562 MW; 46F6A5DE1803EAF5 CRC64;
LPCRFGPENP HSRMNEKRSK KCLIEISRYR FSLVISGLTK MLQRVNELTP STSSQRPFQS
KDQDRQESII IVLDTLEKCL ANTPKDTTKF EEAMNVKLLL REICQFIGMP YDSPQTKMIR
DLASKVLFAL SLNFFNAVFN RISARLQELP NSGDENSDCS DIELMQYINF DVHRLTRLLN
EIIQKVRQLT GKKSAYLVIM NPLEKAIWNW MDTYPQEFAD MQKQPNEDLS KACEELFDIL
DTFVAEKKSR AASVWPLQVM LLILSPKVLE IVNADTGPPD SPRYSKKKQF VDSVKRSLRM
HGSSSSRQLS EAAAVTCVNL IKAATYVSND SITNVVLILA QQLMDDLMTL LFNPSKPFSR
GQNYSAQDID LMIDCYISSF RIDPVNNEAF FKFCLNVNYP STYQIFTQPR LPWWPETSLV
YSYGTDLRNM FTDTLNKMTQ NCSNTPLRMI HNFSLKSKEE MANSKNLLLV LVRLIHVDPM
LMLHSYGTAG HEIQRSTLEL INGLVSLVHQ PTMPDIAHEA MEALLVLHHP DKVKAWNPEA
PLDTFWDASS QVVFSISQKL IQHQIFNYTT ILKWLREILS CRNKVTSKQA HVKLEVVCLM
YLWSIDMEAV LVSMSCFALL CEEAEILCGS DGVAVTCLLP NYQLYLELAQ ASTVLISAHG
ETRLYYQEYN YGRVTLQKKI LSLLRKIEHC VNGIQPAWEE TFRNWEATSR QLSNYPKSKT
EDVQVEPFCR GNVKRRAAHQ NSEHEMEEQI NEWANMTGFL CSLGGVCLQR RSPNRPPYGV
FPFNPEHKKG LIKQQDSVSG LSNSNQEAQC CPVTQFIFNL LRLLICNNEK LGNQIQKHVK
ELVAHEMSPA LYPILFDQIK NFVEKFFDPH GHVVVSDLNT QFIEHTIFIM KNILDSTTDQ
PSEYLGMTSI EGMMLAIVRY VRHLDKTVHS ILIKTKLCQL VEAMMKRRDD LAFRQELKFR
NKLVEYLTEW VMCTHPHSST TANDILTYAT DLDQASMEAV GALLRGLPLQ PEDSDRVELM
EAKSELFSKY FTLFMKLMNY CNGPSSTSED KDVVPRPTLT TNKVAILRNT AIQAMSNLLS
ANIDSGLRHS IHLGYNTDLQ TRAAFMEVLT KILQQGTEFD TLAETVLADR YEQLVQLVTM
ISDKGELPIA MALANVVTTN QMDELARVFV TLFDAKHLLS PLLWNMLYRE VELTDCIQTL
FRGNTLGSKI MSFCFKIYGT SYLQGLLEPL IIPLLDNSTI SFEVDSARID SNENIEQNGE
NLTMLTQKVF NAIVSSADTF PPQLRSMCHC LYQVLCKRFP QSPQSNIVAV GTVIFLRFIN
PAIVSPQESG IINKPVPHDI KRGLMLMSKI LQNIANHVEF SKEQHMLPFN NFLRTHFEIG
RRFIIQIASD CETIDQTSHP MSFVSDANVL ALHRLLWNHQ EKIGDYLSSS RDHKAVGRRP
FDKMATLLAY LGPPEHKPVD SHSLFSTTYV RMSRWANKDM SSTNFEEIMM KYNMHEREEF
KSIQSMNIFY QAGTSKQGYP VFYYISRRFK LGETNGDLLI YHVILTLKPF YHSPYDVVVD
LTHTCSDNRF RTEFLQKWFY VLPTAAYENL HAVYIYNCNN WVREYTKYHD SILAPLKGNR
KIAFIDGQGK LNDVIDVEQQ KLPGATLSLD EDLKVFTGVL KLSHKEMRVS VKIGPTTLQI
THIDRSKVLS QSILLNDVYY ASEIEEVCLV DDNSFVLSIS NEAGPLTFAH NDCNSIVQNI
AHIRSRWTLS HPNSLSVHSK IRPKDVPGTL LNMALLNLGS PDPNLRTAAY NHLCALTATF
GLKIEGQLLE TSGICIPSNN TIFIKHLSET LAANDPHLTL EFLKECMQGF RESTIELKHL
CLEYMTPWLS NLVRFYKPHD EGKRQKQVTE ILDDLITLTV QEIEMYPSIQ AKIWSTIGML
PELIDVVLDI FLQRSARYGL GSPMAEIMAD TAVALASGNV ELVAKKLINK VCRIVDKTCM
SPTTQLEQHI MWSDIAILAR YLLMLSFNNC LDVGKLVCSG SLTMRASTHG LVINSIHSLC
TCSSPAFSED THRILRMSLD EFSLPKFYLL FGISKVKSAA GTAFYKHPNS SNKPVNEKWL
SSDQRSAYGT QDKERLYLTS LEVIPRALIV FGCISKSITD QDMKQLLKIL MKALESFNDI
NLIEAIVMCL TRLQPLLRPE SPIHRYLFWV ATSVLELDET SLYASGLALL EQNLHTLDSQ
GTFDEKTLEH VMMSTREPLE CQFKQLDHTV GLSFKSNFHF ALVGHLLKGY RHPTPTTVTR
TVRVLTMLLA IIAKPSKRDK FEVTPESVPY LTALVAVSEE VRSRCHIRHS LDKSLHDSSG
SSDVLDTLPS RNTEMPGASN PTSRRQKTWD LLDQSALTQA KQQKQSAQMQ LVTNKTGRLL
FKSQRSLSVP SAKDDKSTDN TEQQRDRSTR VSLSNENNVL LDPEVLTDFT TQTLVLTMLA
TLVKYSTSEN ETRILYEYLA EATIVFPKVF PYVHNLLDAK INSVLSSCQD QVILNAVQTI
IQNMIACEDS NQHHLQHYLQ NCGFRGLWRF AGLYTNSNCT PENAELFVNC LKAMVEILEK
YLIQESNSKE EVIRKSKRAN NYQTDFTSKT KSSPVQEQTR VSTEIDVHAD RNTDNKRDDS
IDIRRAEDTG GDDGGGHSRS
//
