ID A0A154WFP2_9PROT Unreviewed; 1144 AA.
AC A0A154WFP2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AUP43_04860 {ECO:0000313|EMBL:KZD12306.1};
OS Oceanibaculum pacificum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Oceanibaculaceae; Oceanibaculum.
OX NCBI_TaxID=580166 {ECO:0000313|EMBL:KZD12306.1, ECO:0000313|Proteomes:UP000076400};
RN [1] {ECO:0000313|EMBL:KZD12306.1, ECO:0000313|Proteomes:UP000076400}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCCC 1A02656 {ECO:0000313|EMBL:KZD12306.1,
RC ECO:0000313|Proteomes:UP000076400};
RA Lu L., Lai Q., Shao Z., Qian P.;
RT "Genome sequence of Oceanibaculum pacificum MCCC 1A02656.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZD12306.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LPXN01000035; KZD12306.1; -; Genomic_DNA.
DR RefSeq; WP_067552619.1; NZ_LPXN01000035.1.
DR AlphaFoldDB; A0A154WFP2; -.
DR STRING; 580166.AUP43_04860; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000076400; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000076400}.
FT DOMAIN 5..489
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 519..789
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 940..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1144 AA; 125821 MW; 12A36E989ADE5CD7 CRC64;
MTTLLPDPAE AQRRAAHPRT SVWVGASAGT GKTKVLTDRV LGLLLQETKP ERLLCLTFTK
AAAAEMANRL NATLSDWAVM ADDALADRLL ALTGERPAPE VMTRARRLFA QVLDTPGGLK
IQTIHAFCQA LLRRFPLEAD IAPHFEVMDE QTARELLLAA RDRMLASARA GQDAALSEAL
SLVTARVNED SFAALMDALA SERGRLDRLL ARHGGLEGLV AAIHARLDVP VGLSDRELIR
DACADAAFDA AALRRAIAVL DGGKATDKKL AAALDGFLAA TDRLPLYANY CGGFLTQKGE
IRARLVTADI AAANPWLMPL LLREAERLIR LEARCRAVRV AAATAALLRL GDAMLATYRR
VKQARALLDY DDLILGTRDL LRSGDGIAAW VLFKLDGGID HVLIDEAQDT NPEQWELIEA
LTGEFFAGLG AREETRTIFA VGDVKQSIYS FQRAEPAEFT RMRDEFRHRA GLVEKAWDEV
ALHTSFRSTE TVLELVDAVF ALDPARQGVV EGTEPLRHLA FRRGQAGRVE LWPLIAPKER
EELEPWQPPV VVRPGDSPRA SLATAIARRI RDWIGRDMLP SKQRPVRAGD ILVLVRRRGG
FVEELVRALK ALEVPVAGID RMVLTEQLAV MDLMALGDFL LLPEDDLTLA TVLKGPLVGL
TEEQLFEIAW NRKGGLWAAL QAAPQDWAQD ATRLLGDLLG RVDYLRPYEL YAEALGHRRG
REKLIGRLGY EADDPIDEFL ARALAYEREH VPSLQGFLAW LRAAQGEIKR DLEAGRDEVR
VMTAHGAKGL QAPIVILPDT AALPILPPPL LWTRDDVQGG LMLWSPNAAS DDAVAGAARE
TAKRRQQEEY RRLLYVALTR AEDRLIICGW ETRKKTPDEC WYRLVEQAMR DRGRELACDF
IDRGAVGRVL ENPQNVTVTI QEKPHRAPIQ PLSPEAWARA MPAAEPSPSR PLTPSRPSGE
EPSVRSPLSV DSETEAARFK RGTLIHRLLQ TLPDVLAERR TAAAARFLAR PVHGLDAAQV
AAYAAEALAV LDDPTFGAIF GPGSVAEVPV VGRIGQGEDS IVISGQIDRL LVSETEALIV
DYKTNRPPPL EAHQVSPVYL RQMASYQAAL EAVYPGRAIR CALLWTDGPR LMPLPDAILA
PYRP
//
