ID A0A158P0A3_ATTCE Unreviewed; 5126 AA.
AC A0A158P0A3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Ryanodine receptor {ECO:0008006|Google:ProtNLM};
GN Name=105626523 {ECO:0000313|EnsemblMetazoa:XP_012063211.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012063211.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012063211.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; ADTU01004756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADTU01004757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012063211.1; XM_012207821.1.
DR STRING; 12957.A0A158P0A3; -.
DR EnsemblMetazoa; XM_012207821.1; XP_012063211.1; LOC105626523.
DR GeneID; 105626523; -.
DR KEGG; acep:105626523; -.
DR eggNOG; KOG2243; Eukaryota.
DR InParanoid; A0A158P0A3; -.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4445..4471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4642..4662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4736..4755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4922..4944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4998..5021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..148
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 576..801
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1030..1213
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1442..1664
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1365..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2268..2287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2910..2937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3567..3595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3855..3875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4490..4512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4529..4575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4533..4552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5126 AA; 581424 MW; 4F563B29EAF475C9 CRC64;
MADSEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHLNS DMYLACLSTS
SSNDKLAFDV GLQEHSHGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
NDLSVVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSPAPS
QNLVIYEGGS VMSQARSLWR LELARTKWAG GFINWLHPMR IRHLTTGRYL GVKENNELYL
VDRNEATIET STFWLRQEKD DQKIILEDKD LEVIGMPIIK YGDSTVIMQH ATTCLWVSYK
SYETKKKGVG KVEEKQAVLH EEGKMDDGLD FSRSQEEESR TARVIRKCSS LFTQFITGLE
TLQVNRRASM FFQNVNLNEM VMCLEDLINY FAQPEDDMEH EEKQNKFRAL RNRQDLFQEE
GILNLILEAI DKINVITSQG FLVALSGDES GQAWDQISGY LYQLLAAIIK GNHTNCAQFA
NSNRLNWLFS RLGSQASSEG TGMLDVLHCV LIDSPEALNM MRDEHIKVII SLLEKHGRDP
KVLDVLCSLC VGNGVAVRSS QNNICDFLLP GKNLLLQTQL VDHVASVRPN IFVGRVEGSA
LYQKWYFEVT VDHIEQTTHM MPHLRIGWAN TAGYMPYPGG GEKWGGNGVG DDLYSFGFDG
AYLWTGGRKT QVVQSATEPY IRKSDVIGCA LDLTVPVITF TFNGTHIMGS FRNFNLDGMF
FPAISCSSKL SCRFLLGGDH GRLKFQPPEE FSPLVESLLP QQILSLDPCF YFGNMNKVVL
AGPWLVEDDT AFVPAPVDTS MVNLPAYVEQ IRDKLAENIH EMWAMNKIEA GWIFGEVRDD
LRKIHPCIVQ FERLPAAEKR YDTQLAVQTL KTILALGYYI TMDKPPSRIK TLRLPNEPFL
QSSGYKPAPL DLSAITLTPK MEELVDQLAE NTHNLWAKER ISQGWTYGLN EDSEMRRSPH
LVPYPKVDEA IKKANRDTAS ETVRTLLVYG YMLDPPTGEQ HEALLLEASR LRQLSFRTYR
VEKHYAVSSG KWYFEFEVLT AGPMRVGWAK ADCMPGSMLG SDENTWAFDG YNVTKVHAGT
HESFGHKYQV GDIVGCFIDV ADRTISFSLN GELLMDALGG ETSFADVQGD SFVPAFTLGV
GQKARLTFGQ DVNTLKFFTT CGLQEGYEPF CVNMNRLVTY WYTKDQPIFE NTDDMADTRI
DVARIPAGSD TPPCMKISHN TFETMEKANW EFLRLSLPVI CQSSFITEGE KLRRWQEIKT
RQNRLLAEQI EQGQQTAPSG HLEQIMKSGF SMSDIKGLQR NYSEDAAEAD EMMKESPLPM
QRGKPARPPR KSSFYGSRLD NAISDAEMNG YGEMNGDIKD EKKKRGRSPF RFFSRKTKSP
ETKSKTPEPQ IRADISDKST KTLGSKSAKT PQIRVSTTDL KVIPPQIPER NVPKAMSVLT
GSGVEAIGNE IFDAECMKLM NEYFYGVRIF PGQDPTHVYI GWVTSQYHLH TKDFNLSRVR
KASVAIIDDY DRLVEQVDRQ SCYMVRADEL YNEVTQDASG KGASQGMFVG CFVDIATGWV
SFTCEGKETS HKFKMEPDTK LFPAIFVEAT SKEILQIELG RTSTTLPLSA AVLQNSERHV
IPQFPPRLKV QCLKPHQWAR VPNQSLQVHA LKLSDIRGWS MLCEDAISML ALHIPEEDRC
IDILELIEMD KLLSFHAHTL TLYAALCYQS NYRAAHALCQ HVDQKQLLYA IRAEYMSGPL
RQGFYDLLIA LHLESHATTM EVCKNEYIIP LGQELKDLYE NYEMKHSLRY LETESIRPQM
KMTEISDQAI ENIKNLYSPH FPLDVVRDYV MMALNEAVEV NQVHNRDPIG GSNENLFLPL
LKLVDRLLLV GMLRNEDIFK LLIMINPETW DPSFDKEGKD EHKKGLLHMK MAEGAKLQMC
YLLHHLNDIQ LRHRVESIIA FAYDFVGELQ ADQLRRYIEI KQSDLPSAVA AKKTKEFRCP
PREQMNAILS FKNLDLEEDP DNPCGEDLIV KMNEFHSELM SYVSLTALQE AANAANEPAE
EIQKPGAMKR LFNFINAVKE LEEESKPEAE PEKKTPEEVF RKVLISTIVN WAEESQIETP
KLVREMFSLL VRQYDTVGEL IRALEKTYIV NNKTKDDVAL MWVGLSQIRA LLPVQMSQEE
EALVRERLWK LVNNHTFFQH PDLIRVLRIH ENVMAIMMNT LGRRAQAQSD AQTQAQAAEG
EPASKEKDTS HEMVVACCRF LCYFCRTSRQ NQKAMFDHFD FLLENSNILL ARPSLRGSTP
LDVAYSSLME NTELALALRE HYLEKIAIYL SRCGLQSNSE LVEKGYPDLG WDPVEGERYL
DFLRFCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG EGLLRAIIEA NKMSERIADR
RKVHDEAEGT TMMMQFEHPL PESDEDEDYI DTGAAILNFY CTLVDLLGRC APDSSVIEQG
KNESLRARAI LRSLVPLDDL QGVLSLRFTL LNPAAGEERP KSDTPSGLIP GHKQSIVLFL
ERVYGIETQE LFYKLLEEAF LPDLRAATML DRNDGYESEM SLAMNRYIGN SILPLLIKHS
KFYNEADNYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF LVALTSQMQP SMLLKLLRKL
TVDVSKLSEY TTVALRLLTL HYDRCAKYYG STGSTGQGAY GASSDEEKRL TMVLFSNIFD
SLSKMDYDPE LFGKALPCLT AIGCALPPDY SLSKNYDDEW YGSKSASTQS PDGPYNPQPI
NTSSVVLNND LNQIVQKFSE HYHDAWASRK LENGWTYGEQ WSDVNKTHPR LKPYNMLSDY
ERERYKEPVR ESLKALLAIG WSVEHAEVDV PSTNRSSMRR SSKSQGDSAN PFNYNPHPVD
MTNLTLSREM QNMAERLADN AHDIWAKKKK EELTTCGGGI HPQLVPYDLL TDKEKRKDRE
RSQEFLKYLQ YQGYKLHKPN RGGTETEVAG AIAAVELRFA YSLLEKLIAY LDKATINMKL
LKPSDTFSRR NSFKTSTRDI KFFSKVVLPL MEKYFSTHRN YFIAVATATN NVGAASLKEK
EMVAALFCKL ASLLRSRLAA FGADVRITVR CLQVLVKGID AKSLVKNCPE FIRTSMLTFF
NNTADDLGHT ILNLQEGKYS HLRGTHLKTS TSLSYINSVV LPVLTAMFDH LAACEYGSDL
LLDEIQVASY KMLASLYTLG IDASLTHDRK YLKTEIERHK PNLGSCLGAF SSCFPVAFLE
PHLNKHNQYS LLNRIADHSL EAQDIMTKME SSMPTLETIL NEVDQFVESE KTYNDAPHVV
DVILPLLCSY LPFWWAQGPD NVSPTENTYV SMVTSDHMNQ LLKNVLKLIK KNIGNENAPW
MTRIAAYTQQ IIINSSEELL KDPFLPLAER VRKRTDTMFH KEESLRGFIK SSTDDTSQVE
AQIQEDWQLL VRDIYSFYPL LIKYVDLQRN QWLRNNISEA EDLYNHVAAI FNIWSKSQYF
LREEQNFISA NEIDNMVLIM PTATRRPATV SDGTAPSGGG KKKKKHRDKK RDKDKEVQAS
LMVACLKRLL PVGLNLFAGR EQELVQHCKD RFLKKMPESD ISEFAKTQLT LPDKIDPADE
MSWQHYLYSQ LGQKKDAMEP VKAQQLEDVV ARITDMAKVL YGLHMIDHPQ QQSKSQYRSV
VSIQRKRAAT KPPPSRDGWK RVLCAARKRA AIACLRSEPL YKLRRHRAIN IFARTYYELW
LQDENVGQEV MIEDLTQSFE DAELKKMDKA EDEGKPDPLT QLVTTFCRGA MTERSGALQE
DPLYMSYAQI ISKSCGEEEE EGEEEGGGEE EGGASIHRPM HKLMEQEMEK QKLLFHQARL
ANRGVAEMVL LHISACKGIP SEMVMKTLEL GISILRGGNI EIQRGMLNHL KEKKDVGFFT
SIAGLMNSCS VLDLDAFERN TKAEGLGVGS EGAAGEKNMH DAEFTCALFR FIQLTCEGHN
LDWQNYLRTQ AGNTTTVNVV ICTVDYLLRL QESIMDFYWH YSSKELIDPA GKANFFKAIG
VASQVFNTLT EVIQGPCAQN QQALAHSRLW DAVGGFLFLF SHMQDKLSKH SSQVDLLKEL
LNLQKDMITM MLSMLEGNVV NGTIGKQMVD TLVESASNVE LILKYFDMFL KLKDLVSSPS
FLEVDLNNDG WVYPKDFKEK MEQQKSYTSE EIEFLLACCE TNHDGKIDYV TFMDRFHEPS
KEIGFNLAVL LTNLSEHMPN EPRLARFLET AGSVLNYFEP FLGRIEILGG NKKIERVYFE
IKESNIEQWE KPQIKESKKT YFYNTVVEAG EKEKLETFIN FCEDAIFEMQ HASALMTVEE
SGGIGKARES SYTYMTEDDE ERNKDPIRRG IQAIKDGVYF FFYMFSPTNI KNKIAEMQQM
TIPELFIGFF KMIFYAFYYS GFGVGCVIKY FMRLLLTLMR GPHVEEPVVI KEEEEKPSRH
LPALPPTPDE SNLQVQAFGM DITKEEGGQI KLAPHESTTS TPQSSIEETG ESTPEEGTGE
DGARAEGGES EPPVTLADLL GGEQARAQAA AAAEAAAAQQ AAMAAVEAEA KQEISVEPST
GSSIDLSQYS HRIVSFLARN FYNLKYVALV LAFCINFMLL FYKVSSLADD SDEEGSGQIA
DLLTEISGEG TSGLAGSGME IGSGSGENGS EEEDEEVQEF VEVSEDYYYM AHVMRLLAAL
HSIVSLAMLV AYYHLKVPLA IFKREKEIAR RVEFDGLYIA ETPEEDDIKA HWDKMVISAK
TFPVNYWDKF VKKKVRQKYS ETYDFDYISN LLGMEKTSFS QQEEEGSGLI HFIVNIDWRY
QIWKAGVTIT DNAFLYSLWY FTFSILGNYN NFFFAAHLLD VAVGFKTLRT ILQSVTHNGK
QLVLTVMLLT IVVYIYTVIA FNFFRKFYIQ EEDDETDKKC HHMLTCFVFH LYKGVRAGGG
IGDEIGEPDG DDYEVYRIMF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ LDNVKTNMES
NCFICGLGKE YFDAVPHGFD THVQQEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ
RCWDFFPVGD CFRKQNETVE EEAKKK
//