ID A0A158P3X4_ATTCE Unreviewed; 746 AA.
AC A0A158P3X4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
GN Name=105627814 {ECO:0000313|EnsemblMetazoa:XP_012064482.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012064482.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012064482.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADTU01008609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012064482.1; XM_012209092.1.
DR AlphaFoldDB; A0A158P3X4; -.
DR STRING; 12957.A0A158P3X4; -.
DR EnsemblMetazoa; XM_012209092.1; XP_012064482.1; LOC105627814.
DR GeneID; 105627814; -.
DR KEGG; acep:105627814; -.
DR eggNOG; KOG1978; Eukaryota.
DR InParanoid; A0A158P3X4; -.
DR OMA; MPVRRQI; -.
DR OrthoDB; 1105861at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00084; HMG-box_SF; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 557..615
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 557..615
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 398..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 85427 MW; C946822BEE06EFA6 CRC64;
MPILALDIKT VKLITTTQII TSVYAVVKEL IENAIDADAD NIEINLVDNG TSLIEVKDNG
YGISKKDAPY MALPSYTSKI ANFEDLDALR TFGFRGEALS AVCAVAEVTI ITKTEEDNVG
TSYVMNNDGQ IVNCESCHRS KGTTVQVRNL FKQVPVRRQI IMNTKKANQT IKLLEILMQC
FGICKPNVRI QFRVNNNIMF TKPSLNNIRE AVNHILGRKI MSNMEWIESK DAEFTLQLML
PSKKVQDLSE ISYPDLHYIL VNNRPIKHKA LEKLANDLIL EHFKQESYRK KIIFLMYITL
SPMDIDINLE PNKDAILFKD QNKVLNAVDK CIRKFYGLKA TEIVEQNVSL DTSVCYEDYA
SNPNENIAEW PACKKRKIQE SIIQENIVKE KSILNNSNEC KKSSQNDQQN DNQTHNQKHH
EDALALTTLI QSPNLSDSDS NDSFSTTTMI KDKVADERLT LSQLPTVDLG EDFDFIEEIE
NSNISMNKND AKTKENIQEK EKITMEMWSK GQVIGLKGGT DIKSDIATEK LNDNLNNKLD
ETLESNRAHV DHKDLNFLKH VRLQVTKENP TLTAAQTARK ITDFWKQLSS EERGYYRDLA
QEEEKEHKTH EKPEGKINAN KVVSGKNKNR LLQLFEKMKN AKNERRENLN MRTIVPWIID
RAKIITRSDF ENEHIIGQLT SNLWVATICE QMWVVDITGL IKGLKVTNID VNKIDAKRIE
LLLKQWLVER DDMSVMHSIH KFAKKV
//
