ID A0A158PMY6_ANISI Unreviewed; 2002 AA.
AC A0A158PMY6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Sodium leak channel non-selective protein (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:ASIM_0001063601-mRNA-1};
GN ORFNames=ASIM_LOCUS10194 {ECO:0000313|EMBL:VDK42501.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001063601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001063601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK42501.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRR01030987; VDK42501.1; -; Genomic_DNA.
DR WBParaSite; ASIM_0001063601-mRNA-1; ASIM_0001063601-mRNA-1; ASIM_0001063601.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF2; PROTEIN CBR-NCA-1; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1039..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1136..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1250..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1332..1353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1365..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1396..1416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1428..1454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1475..1503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1576..1600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..434
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 489..701
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1000..1280
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1386..1610
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1813..1835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2002 AA; 230705 MW; 1B2DB9F54894E91F CRC64;
MFKCSTAKEQ IPTRSLIFVD RILLIRNQFM TLDYPPHSNQ HQATAIYLKR IFSIPKTTFE
QHLSEKTAFT VTKAAVISSA MLARKNSAQR GALNTTRDSI VALADILTTV ETSKSRSGMK
ETFRNYTHLS DLLQSAALVS ALRIACVISL ITVCVHTPVT FQYFWPLTYV VFIMDFISTF
ILTTEAIIRV KVYGTFSRSE SYFRDRWSQF DFFLLIFHWL SLLLHAYERI TRFFPWMGFV
YHEWYGVIRC VRPLIIIRLI RLVVKFKLPK NRIQQLLKRS SQQVQNVTTF FVFFMALYAI
LGIQVFGRMD YHCILKDADP RNISIADLAI PDTMCSMKGE GGYECPDNMV CEKIKMTAKE
EGFYGMFNNF GASVFTVYLA ASEEGWVYVL YDCMDSLPSY WAFLYFVTLI FFLAWLVKNV
FIAVITETFA EIRVQFSEMW QKTDVTFDDG LKQKLEITED GWRLVKFDSE LNRKGGGPIE
LQQILRSTAF QCFITGIVLI NAAINASKLI YAGRFQTGFT ILFNIECIVK IFCYGFRGFF
KRPIYKFELI LCIGSTLNIV PYLYERNYFT IFQGFRLLRL IKASPILEDF VYKIFSPGKK
LGGLVIFTIT FVVICTAISL QLFCSVPKLV YFKTFPQAFM AMFQIITQEG WTEFVVEVLR
MIDDNMVPFV AIYFVAYHLF CTLIVLSLFV AVILDNLEMD EELKRVKQLK AREATTTMRT
TLPWRLRVFE KFPARPAMVE LKRVDNDFPL PKVRDSFTHQ FATVHNDNNP EDCADSTVTK
SVMQSVPLLR HRRKNKPIIR HVGPISLKAS ISTIVEESNR NRATNPDTFT FATHLNRVPT
RLWRKETQHK TTPTLARAKQ MLIEKMTENG DVLRHPDTAP NKSQKLGEID IRALQQKRHM
AEMKRTIAFH DFSFVPDVIH GSNKFLHQKK NDFRNRIEED LRENHLLFDR PLFLIGRDSP
IRRFCKNIVY AKYEAEIEGN GTGKPPRRYK ELHTLIGLMT YLDWTMVIVT ALSCISMLFE
SPWPTTGENL VFNNFYLQIM DYLFVLFMTF ELVVKILANG LFFTPKAVVR DFGGVMTMFI
YITSVVFLLH MPTHVEINSL NQLLLIFRAM RPLRIYTLVP HIRRVVVELF RGFKEILLVT
ILLVVVMFVF ASVGVHIFGG KLAACNDPLI KNRENCTGVF WQKIFVTRLD VYGKNDDELH
PSILVSRVWT NPRNFNFDHV GNAMLALFET LSYKGWNVIR DIVWQRVGPW AVVFIHIYVF
IGCMIGLTLF VGVVIKNYTE NRGTALLTVD QRRWHDLKAR LKMAQPLHVP PKPSESSKLR
NRFYELSMSR PFSQIFGALV VINSATLCIP WSVEEEAERH ENDDDYKLFF ATALSAIINI
LFAAEVPTSR RNRIDLLITA LGLFWVVVHF FIALPAEKFS KEAKLKEFTY TFGYIIVILR
FFTIAGCLFC IPLTRNSFVW KITMLCSGRN GTLKMLMLTV VMSMFRSLFI ITAMFLFVLF
YAYTGVILFG MVKYGQAVSK HVNFRTGSEA MVVLFRSITG EDWNDIMHDC MRSPPLCYWA
EGANYWETDC GNYYGAIIYF CSFYVIITYI VRNLLVAIII ENFSLFYSSE EDALLSYADI
RNFQIVWNMV DVEQKRTIPV RRVKFLLRLL KERLEVDPNK DRLLFKHMCY EMERLHNGDD
VSFHDVLYML SYRSVDIRKS LQLEELLQRE EVEYIIEEEV AKQTIRTWLE VCLKRMRTPS
QVSALLKESH SQNSIFLSDY LKGSVSGPAS ITRGGTTQSS VVSGAVSQHL VEPQLIVSKV
DLIEPITMQD QSNLGADDGL VEKKNKKSTG GSRSSIPDLM SSNIFQEAAK KFMLGGAHKK
SISAYLNKIS DTEAAQKQGP ISRLAAAARL TSQKVESRIS QHKSSYHAPA GLSEVNEFGE
EGGLKSQRSE YYGQRRLSVP DISRPSIAHS VDKDVFRLGA QLKQTPATIA NPAFIHLAMI
DESLQKDRIN DVKWWWRIVD VE
//
