ID A0A158Q5E4_DRAME Unreviewed; 3616 AA.
AC A0A158Q5E4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=GAR domain-containing protein {ECO:0000313|WBParaSite:DME_0000714701-mRNA-1};
GN ORFNames=DME_LOCUS9877 {ECO:0000313|EMBL:VDN59904.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000714701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000714701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN59904.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYG01001194; VDN59904.1; -; Genomic_DNA.
DR STRING; 318479.A0A158Q5E4; -.
DR WBParaSite; DME_0000714701-mRNA-1; DME_0000714701-mRNA-1; DME_0000714701.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 8.
DR Gene3D; 1.20.58.60; -; 20.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 21.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 19.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 3389..3461
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 3537..3616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..341
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 390..417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1206..1233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1292..1379
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2445..2475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3086..3113
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3537..3581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3616 AA; 416035 MW; 5E9387306B62A14F CRC64;
MSGILETLNE ITSAVSQRFC FVTSTEDATL AYDRMQEVRM QLVSWSTKIR ESIDEVERLC
IDGADLLTPQ QFHTLKEQRN RLENVYNQLL RHTDKIIECL NELAKFLLEF TNESSIMHSL
INEKTREIAI IKAESGDLNC YEMSRAKAKA SLEEVISSEY RIKAISSLSS RIQEKLDAYL
VEMRIQYPET QFTSVDIHDL LDTLTRLQKD YEILLRSCHE LNAFLNKLKI CNATYSDNIT
KAEKLIVDIE HSISSIEEIA RNNSVDVDNA CILNELESLQ QATVDQIALN ENVSRSAFEL
DNALVGTDAH DRIVLENQQR IDDLERRQKR VRQRIEEDID SWRSKIAKSE GLREGLAGIL
NWLDDKEEQL SNAPLLPLSI DKLGEMYRDD ELAQRELTSH ENVLKDLSEE IAKLVSSNPN
SANRSLADQV ALAKKKFSSL SAISKAQGDN LYDLLIALKN IDKNSKLLDE RIEIVNDKFS
RVSLADTDSI VNIRAELDDI ISDWKEIQQQ NNWIHAVPNI IEGSSLEQKM TKIENAVDKV
ILRANDLTEQ QKCLLDQRKT FENLKNEFVC WLKTEENEIK ALGRISCNPV ELDAQRNACD
KLKTDHQCHR FDLEKLDELG SKLVEIDIET FAKTKSKSTS GRVTDAQATT VFRDLSCLRQ
QYDGIGQMIK ARFEKINSTN EKFCEWDLAR DDLSRWARNE CRLLDTECPV ALSMDDASKN
ILKLERLEKI CSKEKQPLIE NIRSKAALLM NDSELCDTHL IEISQAEFET HWSALEDQMT
IIKNRTNACK QLIQDYDNLD KWLKQKERMV SVIGAVSVDP KVIDSQVLQI EILQGEIDDQ
NMQRNKINEI AHELVTSNDA NSLQIVNRMD ALNLRWISLE ENVKTMKEAL QKIKNISLQF
AGLHRKIKLD LLEIHENIEK TGRSALTDQD NYNEHVEKFD FLTSQIGEVE KSLESLKTAV
LNSKAEEGAT MKEIEARLKW IRENRNRLAE LGPISTDPRT LPEQCNQIEQ IYQEVLDKEG
EITLLRAKLG DQIKKASNSA LKSIVESIVS EWNPLLIDVK SKKANVERTT DLVKQITSSF
ELFNAKQMQC KASMEQLSLS KLSQRYQKMN GVRRTFMRNL KNSIGAMSLN TDDNSNEIFE
LEQQIERQNV ELISLEALGQ KLEELAAGPS TNKIKRDIEN AINDWKILSR DVRNVTAKHM
QQKESLNRYE KCKEDAMNVL HSAEENLKNL TYDKENNKLT KDAIIKTLTD LESIWQLKNR
DLNAATKELQ NNAYYDGNKN LDDDVVKLEQ FYAHLTESLH DLRDEIEKKN DIFAHFKEDI
QELNKDFRKL INIELEPIAR TGEELQKQRN ECEKSLELLD DKAKKCEELN ERWKELSDNG
VINAAGNLMV LNQLDDIKDD INKQQHVLSQ RKRKISMMEQ SITNNQRFDF SDIDAICGDI
NDLLSDEMLL GPIKTDINEL RSQQESLRQF REKKLRSVGE RVQSITDNCE NLMKSAEPQV
NVGSLEVIKN KLMDLWNDLN GRLDEREKQV CSAIQKVGDY TDTYNSLIIW LQDTEESMAN
QRQPSIEHKV VKEQAHANDI FLKHIEEKKQ SIDGFKAMID SLGKISTNDS QQKVMKDKSD
EIVGRYGKLV EDAYKRRNRL HEALDLTKQW SEVVTPLKVW LEFAEKSLQQ LGKVPTEEKQ
LKEQMDAQKE LLNEIERKRP EFDLIIDLYP QLAQFTSVDE AAELEIIAKS FAARFLDLST
RTNECGDLLH QVAEEIYKFL DHTNTLNDWL DNVEDDMDKL ESISIYPEEL IEQSSFLTEL
ALAVTQQEAL VSKVVEDGRE LCRQTTGDQA IALQSRIEIL RSRYTELASI TDTKIAVLSE
ALPLSERFHD GCEIVQQWMD AVEQDLQDID QVPLEVQSTL ISQIEDDLGK WRLDVDEIGG
ISKQLQRLCD APRADELEAQ TDDLSRRFSQ LADRVTRKAE KLLSAEKQSR QVLDELDYLN
EWFADARERL MNASAPAIDP EYVKKQLKNQ RQMNEDIAIM KARLRDAAAD ARKISRALGD
EVTGQDSLLA TKIESGRNLS ADAARMGEDR LADLEQALAL CQEVDQSFGE LHSWLEKIEN
EIDNCPTVST GNQREQLLKQ QTHNAELQLL VQSQKPLMDR FQKTVNALKE LCDVDDGSQL
EKIAEGIEER YEAIKEAIKQ RAEALETAIE HTSRFSDRLD VILSNLGGTA AQIRNADSIS
ADPDRIRSQI SDNISLMEEL KHKEGVLLSV KEQAREIMEK AKLNDTAVDD ISAKIEALDH
LWLELNGSLS NRGSLLEETL IKAEQFWTEL QKCQKAVDDL RCAIEAIQPA TGQPSIIEQQ
KNTLMVIEGE IREHEPLMMQ NLRVAGQDLC EVVDAEERSY VEQQIDVAQN NWASITDLFV
RKNTDLIDAM EKAMDFHGLL NEILNYLSNM EGKAANLAPV SGINLNEIRD ELNKVNELRA
LLDEKALQKE QLNQLCAGLC VGAQVNHSSA IRMPINDLNS RWNRLYSSLN ERQQQMERAL
LEMGQFSQAY DQLMKWIEKT ETVLDEIDPR PRNLKQAEIE ICKHKVVQND ILAHEGSVDT
LNLAAKRILT ADPNSASITQ PKIDALNARW HTLVDKLEDI WEQLNESRKA AENLGGEIDK
WFLWLQDKDA DLSHAKACGG LPETALAQLD DFLVLKAEIE QNRAELNAHI ENAEKYLLEN
FENGDTWVAQ REVQLKKKWV QVQEKMIDRE QKLRIALADA EELHSSMAVM NEWLSSAETR
LGRLQPVSRI PGTLEKQIAE QSSFQSEISV HREFMTDIHS KGTKMQYYCE KKDAIPIKNL
LVSMKHRFDK IISRCTDRTK QLNSALQESQ IFFSACTDLI EWIDRSTIWL NEQTVQVTSG
DRVREALSKH KEFQQELNDK QPIYDSICKK GKSLSEHAPR DEQNSLNEII ENLRKKWSQI
CSSALQSGEF DEALSSLTEC LAKELPILRE NEKINVHGDL ETVNQLFDAH KSLCEQIESR
QSSMESVRRR AEQIFQCKDD TESLKGLQEK LEKLDVDWTE FNTLAKQRSA RLEEALNEAK
SFDCEVHWIL EFLPCIEARV RAKSNIVEDE NEILEQMDEI AQIRKQMDDE QSRMDSVLTA
GHNIQSKCHP DAEQNMRCWI RILQTRWDEV SQMIDGKRDD LEKHLNELRN QECLIADLLK
FISVKDAELK ILDTGPLPED SDVIKRLIDD HENFEMVLRE HQPQIDDATK SRKRVETEIK
ARNSNVFPRR ERSIRHPKSE QLSDRWKKLW IDSMDYGRRL REMKEYLDEV KRLESFSFEE
WRQRYLEWTD SGKSRISDLF RRIDKSGTGR VPRIAFIDGI IASKFNTTRL EMQKVADVFD
KGDGMIDAKE FMSKLRYDYR KKMPSKQKTD GEKISEEVLR QSEQCNCYNP YKIQKVGEGH
YRFGDTQIKR MVRILRSTVM VRVGGGWVAL DEFLHKHDPC RAKGRTNIDL QRCFYDDVRP
EGAYDTMEVF TKTSRLTPNR DTPLLNFSDS LMSTRYNITP GPITKIREKT ERSMPMYNPR
RASNFSHNSP LITPHSSRRQ SDVTHGSQSD IFNISRSDSR CSDISENFER PTRIPSLRGK
KGIGYGYSSR TNSQSH
//
