ID   A0A158Q782_9BILA        Unreviewed;      1266 AA.
AC   A0A158Q782;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0000313|WBParaSite:EEL_0000380701-mRNA-1};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000380701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000380701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A158Q782; -.
DR   STRING; 1147741.A0A158Q782; -.
DR   WBParaSite; EEL_0000380701-mRNA-1; EEL_0000380701-mRNA-1; EEL_0000380701.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd20821; C1_MgcRacGAP; 1.
DR   Gene3D; 3.30.60.20; -; 2.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 2.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46199:SF3; FI24033P1-RELATED; 1.
DR   PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 2.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00324; RhoGAP; 2.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 2.
DR   PROSITE; PS50238; RHOGAP; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          322..372
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          387..582
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          914..964
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          979..1166
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1193..1234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          52..98
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          634..710
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1193..1224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1266 AA;  143871 MW;  36EC5C772364B70B CRC64;
     MDKIVCSDRS REILKEYNEN NRFAMTLIEM QDKMDILKVL DLLEQMRRNW NYEKMRAEAM
     EEELDQRNKE KDGMRKEIRI YREQLRDART QIATLMSDRK SMEYDIAEWE RKFELVNDLL
     KEQSHLSMED RQRLFGNGST LNKKSATIRG TRSTRLNFSH DSSDEGNIDY DKTADTYDIS
     SNEMDESRLR SGKFRSRSMV SLTAKRTSAV ASKRAKKSML IDTVEEEVET PSKRAKGETE
     THNTVMAAVN AGRNELSTAK VSTRNSMNRS LSAANIFDKS EGTLTLTANM LTPRCGTSSI
     DLRTPLSGVK TWTHGASIST RPHVYTNHSS ILGDHCGVCN GWIGIVGKQA YKCCDCGLHI
     HKACINNAPV PCVPRTPTSR TPAKQRPRLK DLCPSIQPMI PRTIIHCILA LEKDRLFSEG
     IYRIPGLSCV CPSRITSRDD SQVQKLLNEF QTGRSIPKLE YHDTETITSC VKQFLIKLRD
     PVIPSTSWEE FVNAAETNDI EALNHSIIDL PYPNRDTLAF LCAHFQKICE NSIQNKMPPN
     VLARCVAAMI VGPAPPHVVK DDEEKKQVMV MLALLKMPSD YWPKFYNFDN GVPLINSPKS
     RIILNEYAGT ISIAKFLAEG QNTHTEFIHL LDIMENIRQN WNAEKSRADA LQEQMNTREY
     DYDGLRQENR MYKEQLRDAR AQIALLMSDK QNLERDMVEL ERKFALVNEL LKNDQSLLKA
     EDRQKLSFLD RKPPFRAPVT TEGQTHHVRI SRTLSRGEDI DYDKTGDSMD ISYDDSEESH
     LRNGKVYRRS RSLANLPSTQ NSVATMKRSK EPKRMNIVTP CKRSKDGTET IITTTTITVD
     SEGRKPPRAS VSLRRSNRSM SESNILNQNE ETTTESTTKF SAITPRCGAS ALDLHTPCTA
     IKTWTNGSSI ESRPHTFVNF TSILGDRCEV CNRWIGLTGK AAYKCADCGI RLHKLCTSNA
     PIPCVPRTAT PRTPGKQRPR LKDFCPSTQP MIPSLIIHCV LALDKDRLST EGIYRIPGQE
     SLVVKLLNEF KNSRSLPKLE YHDTETITGC IKRFLREIRD PVIPMSSWDE FISAAERDDF
     EALNRSVMDL PFPNRDTLAF LCSHFQRVCD NRSRNKMSPE VLARCIAPTM IGHPPSRVTS
     IAQNAEHIGK QIMVMLALLK MPQNYWSKFF AFDQERPLLK TPASGPTAAI YSRESKTPVQ
     SSFKISSNNG RKDPNKSMLG PVQTPPSGNH PKEFEPLCNK RGKFYLRRFE YSRLNCGSVV
     FETCLL
//