ID A0A158QX18_NIPBR Unreviewed; 486 AA.
AC A0A158QX18;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Alkylated DNA repair protein alkB homolog 8 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0000611601-mRNA-1};
GN ORFNames=NBR_LOCUS6117 {ECO:0000313|EMBL:VDL69706.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000611601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000611601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL69706.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UYSL01019778; VDL69706.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158QX18; -.
DR STRING; 27835.A0A158QX18; -.
DR WBParaSite; NBR_0000611601-mRNA-1; NBR_0000611601-mRNA-1; NBR_0000611601.
DR OMA; ICECIYP; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0008175; F:tRNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13069:SF21; ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8; 1.
DR PANTHER; PTHR13069; UNCHARACTERIZED; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 116..221
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 486 AA; 55035 MW; B383B32F3386929A CRC64;
MMYFNPAKER PVGCRLDGGK LARKTHKSWA QLKRHDPDVV ISEEPTEHLF VSNSSVLCGV
TLEELEEVFL PFDSNAIFTV FPNKSINAAF KPTSPMPAIV EQLIDRLTGE KVIAFRPDQV
TVNIYEAGQG IPPHFDTHSA FEDPIVSLSM CSDVVMEFKD AANSALICPV LLKRRSLCLI
GGESRYRWKH GIVNRKYDIN PLTNRLMRRE LRVSLTLRKI RHEPCQCPFK EFCDWDRGGE
MAVPSDESAA QRIEKLYVNG VYDNIASHFD ETRFSSWSGV KRFLDSLPDY SLVYDIGCGN
GKYLLLKNSL CKIGCDMSRM LCEIADGKGC MVVHADGLAI PFREVADAVL SIAVLHHMAL
LSRRQQLIKE ILRVSIVTVY NIVNIRDITN LGVKKYAKMR ENKDISTDAA QLDRLLIHDG
KDFVQQDMLV PWRIDEKGET FLRYYHVFAE GEMEELLRSV GGCTIDSIEK EQGNYIATIT
KTCNIS
//
