ID A0A161LYG9_9ACTN Unreviewed; 1050 AA.
AC A0A161LYG9;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:GAT70869.1};
GN ORFNames=PS9374_06557 {ECO:0000313|EMBL:GAT70869.1};
OS Planomonospora sphaerica.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Planomonospora.
OX NCBI_TaxID=161355 {ECO:0000313|EMBL:GAT70869.1, ECO:0000313|Proteomes:UP000077701};
RN [1] {ECO:0000313|EMBL:GAT70869.1, ECO:0000313|Proteomes:UP000077701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9374 {ECO:0000313|EMBL:GAT70869.1,
RC ECO:0000313|Proteomes:UP000077701};
RA Dohra H., Suzuki T., Inoue Y., Kodani S.;
RT "Draft Genome Sequence of Planomonospora sphaerica JCM9374, a Rare
RT Actinomycete.";
RL Genome Announc. 4:e00779-16(2016).
RN [2] {ECO:0000313|Proteomes:UP000077701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9374 {ECO:0000313|Proteomes:UP000077701};
RA Suzuki T., Dohra H., Kodani S.;
RT "Planomonospora sphaerica JCM9374 whole genome shotgun sequence.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT70869.1}.
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DR EMBL; BDCX01000020; GAT70869.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A161LYG9; -.
DR STRING; 161355.PS9374_06557; -.
DR Proteomes; UP000077701; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000077701}.
FT DOMAIN 951..1026
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1050 AA; 110995 MW; 66C3DB11379A61F0 CRC64;
MTGVTAKEWE APASFGQERI WLADQMDPGS PVFNLQCPVE VPHALEADEV IAALQAVTER
HEALRTSLRI VDGALRQVVH AEVEPDVRVH DLRALPEDER RTRSYGHALA VTEAAFRTDR
APLWRAALIR TGDARWVVYL VVHHAVFDAA SSVILSEEIT ELCAAAAAGR PAELPELPVQ
YADYAAWQRD RLTGPALAEQ TDHWRARLAG LPAVHALPTD RPRPARLGYA GDEVRFTVPE
GLQEQVAAAG RRAAATPFMV YLTAYAALLS RLSRDDDVVV GVTMSGRDLP EVAGLVGMFV
NQMAVRTDTS GEPSFAGLLG RVRATLLDAM EHGQVPFQAV VEAVTPQRDP GVQPLYQIGF
NYIPDSGIEP IPYVTSKDDL AFDLTTGVSR LLYRTDLFDR GTAEKFVERY LRLLAAAVAD
PETRIGDLPL MDEAERASLL EAGTQEPPYE HATALRMVEA QAARTPDATA VIAGDRRLTY
AELDEAAGRV ADRLRRSGVG PESLVAVYAE PCLELLPALL GVWKAGAGYV PVDPAYPAGR
VAYMLADSAA AVVLTRRHLA GALPAGGATV LAVDDAAEWA AERAGGPEAG SAQAAGPGNV
AYVIYTSGST GTPKGVVVEQ GSVAAYLAWA GTAYPGLAGQ ALLHSPISFD LTVTGLFGPL
TVGGAVRLAA LDESAATGDR PTFLKATPSH LALLAALPDR VAPAADLVLG GEALPADAVT
AWRERHPDVT VVNEYGPTEA TVGCVMAAVA PGEELPVDRA GAVGIGRPAP GSAAYVLDDG
LRPVPADVVG ELYIAGPQVT RGYLNRPGAT AAAYLPCPYG PPGRRMYRTG DLARRRADGS
LEFAGRADDQ IKLHGHRIEP GEIETALRAL PGVRDAAVGV REDASEGRRL VAYLVGEADA
AAVDGALAAT LPAHMVPSGY VVLDALPLTA NGKLDHAALP APAAPERRYI APRTAAEELV
AEVFADLLGV EKVGAEDDFF ELGGNSLLAI RAIARIRGRI EVDIPVRGLF SHTTVADLAA
EVERRLTEDL DGLSDEAVER LLAAEGDGRT
//
