ID A0A162PYE1_PHYB8 Unreviewed; 961 AA.
AC A0A162PYE1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PHYBLDRAFT_109402 {ECO:0000313|EMBL:OAD77137.1};
OS Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC
OS 33097 / NRRL 1555).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Phycomycetaceae; Phycomyces.
OX NCBI_TaxID=763407 {ECO:0000313|EMBL:OAD77137.1, ECO:0000313|Proteomes:UP000077315};
RN [1] {ECO:0000313|Proteomes:UP000077315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1555(-) {ECO:0000313|Proteomes:UP000077315};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA McCluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV440975; OAD77137.1; -; Genomic_DNA.
DR RefSeq; XP_018295177.1; XM_018428112.1.
DR AlphaFoldDB; A0A162PYE1; -.
DR STRING; 763407.A0A162PYE1; -.
DR GeneID; 28989018; -.
DR VEuPathDB; FungiDB:PHYBL_109402; -.
DR InParanoid; A0A162PYE1; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000077315; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09392; LIM2_Lrg1p_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15670; RHO GTPASE ACTIVATING PROTEIN 11A; 1.
DR PANTHER; PTHR15670:SF4; RHO GTPASE-ACTIVATING PROTEIN 11A; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000077315};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 12..75
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 76..135
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 374..437
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 727..929
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 514..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 961
FT /evidence="ECO:0000313|EMBL:OAD77137.1"
SQ SEQUENCE 961 AA; 108166 MW; ECC6F1FA29CF70AF CRC64;
MEPNPDAIQS QITCAKCHDL VGSRFMKALG KEYHPECFTC LDCGVPVASK FYTFTLDSNQ
TLHLCERDYF ARLDLICDNC QDFLKESYII AANKKYHTDH FTCSACPVVF GPEDSYYEHN
GQVFCHFHYS IQFAVMCAGC EMAILKQYVE IDRKDDVEHW HPECYMIHKY WNVRIAQPSI
EDAVDRSPQT PSQLLEKHQE TEEKVFRIWQ VLSAFEESSA LCISEMLLHV SNGSYINGIC
ISERFLVHVE ALFSGIDELL MIYHEHKQQE FKYTREAKML CKKIINFFSL MWKTQEVEMR
KLGISQELLS LITGLAHYLK ILIRVALSAA LRLDLIVGKP VAVSRLLAKL MEVAGKERHS
RDSQRLVKSK EATDCCCCCK LSIEDQCMKS GQFRWHIRCF VCHQCKRSLA DHTHLAVFNA
SSHTLMCTRC SGSRDSTTNS FEYVTKLVQY AFLLRVALSR LCSLLHITGT KSLSLSLLIS
RSFKTAKRST IIGNANTSII DDVEQGTSAT TANINKIDNN TGTNTDNSND NTNTAANRPA
PARSDSLVRL SDQNKELPPL PTHALANKTR HRPQKSIGLD DLPQFAALTV AEHPPYSLGR
ATATPTTLPS TQLSPHHPPT QPQTHNQTHP YTHPVATTAM AGRMFAPHAG TRSRIYLSEL
SALQYMIIRH VAVVHIEPYV REHFTLGELL NMIELKKASI WGKFFTSFRT GGGRKAQKCK
EEGTFGVPID VLTEKTGVES NLGAGPSPIK IAGFLDDAIT AMRQKDMSVE GVFRKNGNIR
RLKELTEQLD KHPHDVDLTS ENVIQIAALL KRFLRELPDP LLTFKLHGLF TCAQKITNPS
TRRHVLHLAC CMLPRCNRDT LEVLVLFLRW VASFSHVTTD VGSRMDIPNL ARVIAPNILT
TDSKDPVKDD SFSAIGVVEV LLESCEELCL VPEELEPFLQ DPSLADASAM MDISSKEFLK
K
//
