ID A0A163DLZ1_9NEIS Unreviewed; 791 AA.
AC A0A163DLZ1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KZE34957.1};
GN ORFNames=AVW16_05610 {ECO:0000313|EMBL:KZE34957.1};
OS Crenobacter luteus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Crenobacter.
OX NCBI_TaxID=1452487 {ECO:0000313|EMBL:KZE34957.1, ECO:0000313|Proteomes:UP000076625};
RN [1] {ECO:0000313|Proteomes:UP000076625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CN10 {ECO:0000313|Proteomes:UP000076625};
RA Hong K.W.;
RT "Draft genome of Chromobacterium sp. F49.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZE34957.1}.
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DR EMBL; LQQU01000004; KZE34957.1; -; Genomic_DNA.
DR RefSeq; WP_066609817.1; NZ_LQQU01000004.1.
DR AlphaFoldDB; A0A163DLZ1; -.
DR STRING; 1452487.AVW16_05610; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000076625; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000076625}.
FT DOMAIN 10..193
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..295
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 791 AA; 86011 MW; E4694199E2710CF5 CRC64;
MSESKFIVRK VAVLGAGVMG AQIAAHLVNA KVPTILFDLP AREGDKNGIV KKAIDGLKKQ
KPSPLAGKGL EQYIQPANYE EHLHLLKDCD LVIEAIAERI DWKADLYHKV APHLGERTIF
ATNTSGLSIN TLAEACPEGV RPRFCGVHFF NPPRYMHLVE IIPCASSDAA MLDHLERFLV
STLGKGVIRA KDTPNFVANR IGVFSMLATI ANAEKFGIRF DVVDDLTGPR LGRPKSATFR
TADVVGLDTF AHVVKTMQDT LPDDPWHGLF KSPEWLQKLI AAGALGAKTK AGIYKKDGKQ
MFVVDPAKGD YVGAGEKGDD AVKDILKIAD PAEKFRKLRE SEHPQAQFLW ACFRDVFHYI
GYHLADIANS ARDVDFAIRW GFGWSVGPFE TWQAAGWQQV ARWVDEDVKA GKALASANLP
AWVLEADRVG VHFADGSFDA ASGKRVGRST LDVYARQLAP ARVLGEASAP LGETVFENDG
VRAFSTGDEV LVVSFKSKAH AIGPDVLDGL NTALDIAEAR FKGLVIWQTE EPFSVGADLA
SMMPAFMMGD WDAIDATVRR FQQTSMRLRY SQVPTVAATQ GYAFGGGCEF AMHCDKVVAA
LESYVGLVEV GVGLLPGGGG CKEFALRAAQ EARGDILPAL KDYFMAVATA KVATSAVEAQ
EIGYFRKTDT VVFNAYELLY VAKQQALAMA EAGYRPPLKV KGFPVAGRAG AASIKGQLLN
MLEGRFISEY DFTIASLIAD VMTGGDVEAG TEVDEQWILD LERKGFMQLL KNGKTQDRIA
NMLTTGKPLR N
//