ID A0A164WKK5_9CRUS Unreviewed; 846 AA.
AC A0A164WKK5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Putative MLH2, MutL protein 2 {ECO:0000313|EMBL:KZS13350.1};
GN ORFNames=APZ42_021543 {ECO:0000313|EMBL:KZS13350.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:KZS13350.1, ECO:0000313|Proteomes:UP000076858};
RN [1] {ECO:0000313|EMBL:KZS13350.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS13350.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS13350.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZS13350.1}.
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DR EMBL; LRGB01001200; KZS13350.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A164WKK5; -.
DR STRING; 35525.A0A164WKK5; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00084; HMG-box_SF; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858}.
FT DOMAIN 534..602
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 534..602
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
SQ SEQUENCE 846 AA; 95449 MW; 16369C49FAD15211 CRC64;
MVEKKVISEL PYSTVKLITA TQIATSVCNI VKELVENALD AGSTVIRVKL ENSGLSKIEV
IDNGSGVSKE NVFKMALPHY TSKISQHQDL EALATYGFRG EALAAICAVA KLSVTTKTAE
DPVATTFVMD NNGEVINQKP SHLSQGTLVA MTSLFWNIPV RKQYYQTPKR KKEELIKVEE
LLLSYGLIHP ELHLSFHHDH SLIWQKNRAI DFKSNVQQTL GHEICSHMEF LSEDDLIQVF
LMAPKRSAPL DICFRNRADL CFVFINKRPV VSKEIEKLMK ELYAFNRDDN QKSTLFPIFI
VSLHFPGDEV DVNVEPNKSK VLMKRQGDVL ELIRNRVENF LGASVMENST KISLPSEMYK
DSSLLVNSNE VPDVSVVEET IMEDQNESPF QTPLSTQFEI TQNSQLGINQ FESTRIDSSV
NDFPEDDCLF HGFNEPFQIE VEEANVEKST SSNQSEIIAI GSDQWSRGLA RDSEGRTVHA
IQVLRGQPHL DKRQPDPSIT GNVAKKPKLI ETLEASRIVG LSPTLLETVN GSVRKIPPDP
FGEYCKEMRN ELLSQDPLMS FTELSQHLSH GWKNLDKSSR EKYEKKAETN KQRYNANKLK
TTKASTMSNT SLDRFLVGQT SVARVDTTPT RHVVETAPPA KRTSISVDFS LNVLSRSLKS
LQQKPKCQWF CMEKFENCGW LCSNGHMVMA VNFTRLYEMI LIFGDLEGWR KLLSLPNEWE
SATTRTITDV RLVANGVGIR LSAESEDANL MVYQVPSNVK RFELNDVKSL LRQVVKNGST
VESCRPEQTL VNLKFEAARL AAERCTEPDE GEVRELLEQW LSTESENVCL HGEPIIWNYP
LNAQAV
//
