ID A0A165U3Q0_9GAMM Unreviewed; 579 AA.
AC A0A165U3Q0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:KZX58868.1};
GN ORFNames=A3709_17955 {ECO:0000313|EMBL:KZX58868.1};
OS Halioglobus sp. HI00S01.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Halioglobus.
OX NCBI_TaxID=1822214 {ECO:0000313|EMBL:KZX58868.1, ECO:0000313|Proteomes:UP000077184};
RN [1] {ECO:0000313|EMBL:KZX58868.1, ECO:0000313|Proteomes:UP000077184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HI00S01 {ECO:0000313|EMBL:KZX58868.1,
RC ECO:0000313|Proteomes:UP000077184};
RA Sosa O.A.;
RT "Microbial cycling of marine high molecular weight dissolved organic
RT matter.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZX58868.1}.
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DR EMBL; LWEE01000030; KZX58868.1; -; Genomic_DNA.
DR RefSeq; WP_066052509.1; NZ_LWEE01000030.1.
DR AlphaFoldDB; A0A165U3Q0; -.
DR OrthoDB; 9765655at2; -.
DR Proteomes; UP000077184; Unassembled WGS sequence.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 2.
DR InterPro; IPR004790; Isocitrate_DH_NADP.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 2.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000077184}.
FT DOMAIN 4..573
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 579 AA; 64062 MW; 1BEF65633F217607 CRC64;
MTNKIQVAKP MVILHGDEMA QIAFERILEQ FVTSRLDIDL VEIDLSAEQR LTSNGQVVLD
AIDSLKEHGV GIKNAGMTVN RSQLDDLLAK YPDISEAALD KLATKSPNGA IRKGIGGNIT
REDIEFRNLK SVRPDWVGRE IEVDTMDSGG LDFSYSELSD ATGVAKVYFV GSSGDPVELH
RRTLRKGDPW MLASNDLDEV KAWAHRFFQR ALDEKRDIYL GLKDTVVAGY DGVMRAAIEE
VYNSDYKDKV AAAGLEYHYE LIDAQAARIV SNPPERALWG VPDNVSGMKL YKLVQQLKRY
GLPERKAHVS ISRMSAGGGD QYGSYNTPAP EDGIIKVVMD GVEKHARDVK AGDPLLFMSN
DRAAIKDWVK QVFRDAALNK KEVYFGLKRE FVNYDEVYSS IILEIRKELA ALDTPPPSFM
IMRPSRQLSK MICDPPRWGL YPAQNLDGDI FSDISAALGG SLATASSVIE SKDGTMLYEA
PHGTAHDLYL RYLETDGKEA NFNSSALIFA VANALEELAR REDNAALAEY SSRLKSALIE
TVAQGTITGD LKGKTLNPDD EKVVDMYGFL DAIEANLES
//
