ID A0A166TPM5_9EURY Unreviewed; 369 AA.
AC A0A166TPM5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha {ECO:0000313|EMBL:KZN25890.1};
GN ORFNames=A4G99_00485 {ECO:0000313|EMBL:KZN25890.1};
OS Haladaptatus sp. R4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haladaptataceae; Haladaptatus.
OX NCBI_TaxID=1679489 {ECO:0000313|EMBL:KZN25890.1, ECO:0000313|Proteomes:UP000076599};
RN [1] {ECO:0000313|EMBL:KZN25890.1, ECO:0000313|Proteomes:UP000076599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R4 {ECO:0000313|EMBL:KZN25890.1,
RC ECO:0000313|Proteomes:UP000076599};
RA Mukhopadhyay S.K.;
RT "Genome sequence of halophilic archaea.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZN25890.1}.
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DR EMBL; LWHG01000011; KZN25890.1; -; Genomic_DNA.
DR RefSeq; WP_066142295.1; NZ_LWHG01000011.1.
DR AlphaFoldDB; A0A166TPM5; -.
DR STRING; 1679489.A4G99_00485; -.
DR OrthoDB; 25266at2157; -.
DR Proteomes; UP000076599; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:KZN25890.1}.
FT DOMAIN 39..330
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 369 AA; 41412 MW; 74642B0E21C9A2B6 CRC64;
MSIVHQDPQD RVQILDEDGT VLDGMEVPDL SDEELVEMYR QMRLARHFDE RAVSLNRQGR
MGTYPPLSGQ EGAQIASVSA LSDDDWMFPS YREHGAALVR GLSLKQTMLY WMGHEAGNHI
PDDANIFTVA VPIATQIPHA TGAAWASKLK GEDKAFLCYF GDGATSEGDF HEGLNFAGVF
DTPSVFFCNN NQWAISVPRE RQTASATIAQ KAQAYGFEGV QVDGMDPLAV YKVTKEAVEK
AKNPDEGERR PTLIEAVQYR FGAHTTADDP TVYRDDDKVA EWKKKDPIPR MEKFLLNTGR
LDESDVEEID EGVKQDVADA IDAAEAVERP DAVEIFNNVY AEMPRRLREQ MESFEHLREQ
YGDETLLEE
//
