ID A0A168HNF8_MUCCL Unreviewed; 1128 AA.
AC A0A168HNF8;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MUCCIDRAFT_148649 {ECO:0000313|EMBL:OAC98997.1};
OS Mucor lusitanicus CBS 277.49.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=747725 {ECO:0000313|EMBL:OAC98997.1, ECO:0000313|Proteomes:UP000077051};
RN [1] {ECO:0000313|EMBL:OAC98997.1, ECO:0000313|Proteomes:UP000077051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 277.49 {ECO:0000313|EMBL:OAC98997.1,
RC ECO:0000313|Proteomes:UP000077051};
RG DOE Joint Genome Institute;
RA Corrochano L.M., Kuo A., Marcet-Houben M., Polaino S., Salamov A.,
RA Villalobos J.M., Alvarez M.I., Avalos J., Benito E.P., Benoit I.,
RA Burger G., Camino L.P., Canovas D., Cerda-Olmedo E., Cheng J.-F.,
RA Dominguez A., Elias M., Eslava A.P., Glaser F., Grimwood J., Gutierrez G.,
RA Heitman J., Henrissat B., Iturriaga E.A., Lang B.F., Lavin J.L., Lee S.,
RA Li W., Lindquist E., Lopez-Garcia S., Luque E.M., Marcos A.T., Martin J.,
RA Mccluskey K., Medina H.R., Miralles-Duran A., Miyazaki A., Munoz-Torres E.,
RA Oguiza J.A., Ohm R., Olmedo M., Orejas M., Ortiz-Castellanos L.,
RA Pisabarro A.G., Rodriguez-Romero J., Ruiz-Herrera J., Ruiz-Vazquez R.,
RA Sanz C., Schackwitz W., Schmutz J., Shahriari M., Shelest E.,
RA Silva-Franco F., Soanes D., Syed K., Tagua V.G., Talbot N.J., Thon M.,
RA De Vries R.P., Wiebenga A., Yadav J.S., Braun E.L., Baker S., Garre V.,
RA Horwitz B., Torres-Martinez S., Idnurm A., Herrera-Estrella A.,
RA Gabaldon T., Grigoriev I.V.;
RT "Expansion of signal transduction pathways in fungi by whole-genome
RT duplication.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAC98997.1}.
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DR EMBL; AMYB01000008; OAC98997.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168HNF8; -.
DR STRING; 747725.A0A168HNF8; -.
DR VEuPathDB; FungiDB:QYA_148649; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000077051; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09392; LIM2_Lrg1p_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000077051};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 24..84
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 85..145
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 382..443
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 731..933
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 568..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 126756 MW; 4EBF359B390EEA33 CRC64;
MSQQQDTAPP TPTTPIADNA KHALVCSKCN LPLGDQLVRA LDGAFHPECF TCWDCNTPVA
SRYLPHPTEL GQPLCERDYF RRLGLVCAQC NEALRGTYII ALDRKYHTNH FTCNDCSTVF
GPDDSYYEHD QKVYCHFHYS TRFAVSCAGC DMSILKQYVE IERNDVVDHW HPECYMIQKF
WSVKIAHPTQ KENDPIPQSP LELLKTQKEM EEKVISIWSV LSAFEESSAV CISEMLLHVS
NGAYIESICL SERFLVHVEA LFAGIDKIQS VYQEYKQPEF KYTREAKMLC KKIINFFSLL
SRTGDMEMKK LGITQELLSL VTGLAHYLKI LIRLALTSAL RLEITVGKPV VVSRLLAKLM
EIPGKERHSR DCQRLIKAKN TDFCYACRNT IEDQCMRSGD YRWHMACFKC RQCARQLNHD
DAVLNSASCT IHCVQCVGVT KREATPFEYI TKLTQYSFLL RVALSRLCNL LQITDTQLSS
VDYSSKIKPN AAGSNNPLIK DAAVQLSPSA EKQLTIMTDD KFYPTEITDA KNTVSSSTTH
LDRKVSRSFK SANKRSTILG NADLAASLKT QPQSSLNNAT TMPPPPARMD SLQRTRADQH
KDLPQLPAAR TPTRHKPTRS VGLDDLPQLA AAAVASKKHM MTHLPHNIHI TTGPSGKPRI
YFSELSALQY MIIRYVAVVQ IEQYVKSSFS SSELLNLIEF KKSSIWGKFF IPFKAKKNHG
PKAKEEGTFG VPLDILTERT GVESNLGSGH SPLKLASFID DAITAMRQMD MTVEGVFRKN
GNIRRLKELA DALDRNANDV DLTQENAIQV AALLKKFLRD LPDPLLTHRL HPLFMCAERI
ENPAERRRAL HLACCMLPRC NRATMEVLFV FFRWVASFSH VTGDVGSRMD IPNLARVIAP
NILTANSKDP LKDDSFASIR VVEVLLESHE EFCLVPDDLE AFLQDPNLSD VDISPKEFLK
RVEQTVKHKH PSSSGAGAAA GASSKSSMHS TSSAPNNAEG VKLFDGTVTD GRQHPPTSIY
AQQQYLPYTN NHPNSDFVPQ QLNMRYHQPG SPVPAPPRRM DSHESFASTT SYYPNNHIDH
HLPSPQHRFV PQHNNHQQQH HHHHQQSPLN TVPTSTSSPV ANAIPTPL
//
