ID A0A171DIL0_9ACTN Unreviewed; 11486 AA.
AC A0A171DIL0;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=PS9374_04402 {ECO:0000313|EMBL:GAT68737.1};
OS Planomonospora sphaerica.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Planomonospora.
OX NCBI_TaxID=161355 {ECO:0000313|EMBL:GAT68737.1, ECO:0000313|Proteomes:UP000077701};
RN [1] {ECO:0000313|EMBL:GAT68737.1, ECO:0000313|Proteomes:UP000077701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9374 {ECO:0000313|EMBL:GAT68737.1,
RC ECO:0000313|Proteomes:UP000077701};
RA Dohra H., Suzuki T., Inoue Y., Kodani S.;
RT "Draft Genome Sequence of Planomonospora sphaerica JCM9374, a Rare
RT Actinomycete.";
RL Genome Announc. 4:e00779-16(2016).
RN [2] {ECO:0000313|Proteomes:UP000077701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9374 {ECO:0000313|Proteomes:UP000077701};
RA Suzuki T., Dohra H., Kodani S.;
RT "Planomonospora sphaerica JCM9374 whole genome shotgun sequence.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAT68737.1}.
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DR EMBL; BDCX01000011; GAT68737.1; -; Genomic_DNA.
DR STRING; 161355.PS9374_04402; -.
DR OrthoDB; 9814088at2; -.
DR Proteomes; UP000077701; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:GAT68737.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000077701}.
FT DOMAIN 5469..5734
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 431..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2619..2677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3053..3075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3094..3187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3730..3790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3828..3848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4048..4177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4917..4937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5057..5077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5323..5373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5970..6054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6864..6886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6935..6963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6991..7063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8756..8801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9545..9564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10109..10136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10711..10741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10782..10857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11109..11138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11462..11486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..518
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..682
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1266
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1379
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3131..3151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3758..3785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4161..4177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9549..9563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10711..10737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 5490..5497
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 11486 AA; 1238868 MW; 45D5637BCE3E2B95 CRC64;
MAISVLRAAR RHPLVRRVQR AVAIGRRRGE YLAGMRGQRA RTAQAHGDAA LATYARQMQA
QLAAAQPSMR QVYDPAWWVQ ASPERLGAAW QLIVSWAALA EPGAQAALAH LSAQTEARYG
VRVDNVRMQA RDVVGLLARA WPPSARAPRP GGQAPADEPV YSYVIRDLWQ QTIVAQQIGC
RPGAGIAPAL FGAEQLLAFD AGLGAATGTT GPARSLRFAI EVYPGEDVTA TPVADVSGLH
AAAVRQQALE RREKVLAGAP ADAQELHDAL LVEQRRLHDL IAVHRSPDTE EITAPVHIPA
AESALQEQLA YVQVRLEATE ATLRGENGEH VYQRAALLHW LDDAWWRSAS AQEIAEVWAQ
VTGWGEGAAK RQTLDVLAAE LHAHRDVTVS LQTTAAQLLD ELTVVIVDEP PAAPDPSRPA
APVADQKVWP ATGVDAAPPT GDAVRAPVTG DHASAAPRQG VPAARPDIGT QQPVTDPDPD
TTPPAPAAAA TPVTGPPAPP RAAPAPSSAP PVQPVEPDRS TAPPRSAPDV RDSAPSAAQP
AAPSPPGSLG DEHVADSTGI PDASAAPARE AASAAAPSDA PAADRQDSAP AAPGAAAPQR
DTVTPGAAAA TPPPRSHDLP PAASAPAPPA RPEPPAPARA PLPAPAASTA PPRPGTAAGS
DPRVGTAPPE PERTPSPPLP EPSGRRDRFA SAEELNAARA VLQRLYQAWT ATPTATLLHK
EEEELRAELG TAGTNEGAFI DLAWRKLSPA SDAPGPAAAG YAGLLEACTT GERLLAARQA
FVTADDRHIL QLLAAHASEL TVRLRATAAS GPPARTAPAG VRAPDRRTRL GDTPGSPAVP
RDRAPAAPPP SAGREQPTRA DTPASAPVPA LTPPQPHPAA RPTGARFASL AELRAFYRQQ
GSALADEATL GLGRDGFLAY HRPADRVAWQ LLHAATATPI RRTDFPGGSD VLPEWGSERA
IRRLLATIEH LRDAQGQPVD WDTDDPAILR QRIDAFRTGD GESWWDALLR VTAEHDIAGG
HPTTSAARGW LAIRTDPDRP ALPEGHSYGD QLRPGMTLTV REDDHAVPTS ARITAVTPGH
RTGQFQVHFD NGTDITVLRN ERFLLGEAAI VRDRSGAVRE ELVLTADLSA GQRVRWTTTA
GAVDLELLER GFRPGETVTI TGMFLGRDEQ DPSLILLGTV EVRSQQRERV VLVPDVHEVD
APARVMLLHP PAQERTEPPA DTPSTDLAPA AVPGPERSPA PAGDEPVASP DPPPAPAPPA
GPRPFGDAPA SAPSHVPAAP APADPPPVRP GSAGRAGDGA PESLGEVDGD QMMLVIGEPT
PLSRRATAPS GTAGEPSAPA ISAAVPGPQA TPPATSAIEQ PTASPPPSTS APAAPAAPAA
PAAPAAGGAA APVSGPATDA DTARALGQLP SSLLATLLRG RDDPRHLRFL HVALDHLRSS
GQPDADSAPQ LEITAAGLRI SADGHRESSL TWQEVIQWLE PAAELPQCDI LRRADLLHAR
YASGEESLRL VGQAQLGALV REELRDYQAQ AATSILQAAQ AAHERSPGGR PAARVRPKTR
RDAPDDNALL SIGEVAPDDD PEERAAAILK RLERLEALAP PRAGAGTPVR VRQLKAGMVI
TDPQQSRWPL RLTGAATSTG TGLQLSGALL QPGQPQPDTA WSYPADAGAD EPTVWALRSP
PSLRELDGTF PANVTGKAGL APSSAARERD DAAAAERAWP GFATLSELLA YLESFPPEMR
PERQRRATPF GPADTDDTYA AKIKKQKDLA GHIRRCRELA LSPGGHLLIY TDRDGRRQIA
LARTLLHLPA VFLEGRSSQQ AVALAGWIEQ QVRDADGAVF PWSSPQARQE IRQWHSADGR
SIRQEIQRQI AAYDRAHGIA SLAVREDDEQ QAADQQRQRP AAGSITPQEI TLGERIRVIS
RGGVWVQGHV QAITDHPSRP VVKVVRLRES DGTEATQEID PAEHSVIRLP DLQAAPTGPR
VGAPASRIDA DSPSDRLSAP AGEPTRLHDA DDPQPPAAAE RTEAFPDAPV LPEPSASAAA
SPAPELRAPA RSWPDERDAR LLDAAEALTP DVFTAADTAR IQTALTGLAE AVASPREVEV
YQAWMVAEHV LATTPPPADG AGAAAERERQ RLLQVVRAAV RARENRFATP SKISIESLIL
HGSFGLQDGY DAEQMAAAAR TVLAAALADL PLRAAAAATD KDDFTERVFS LWLVRLVRSG
EAALPPEFRS LYFSHVQHDL HQRLAAAVQG VVALEGVAPG HPDTAIIPAQ PRDEVERAQD
RILTALREAG VAFYVIHRDG GHTSIQMSYD GKQQESAHLP LDVAAARFAP QLGIAPQPLY
DSDIIDALAQ RSPGWWASFI NSIDEAALHL GGYGSVLTLR TAVEVTADNL SIEVRDVDGT
RRGTVPWRQI IDRWIRPVLT DQHRLIMRTW LDVSAQYTRC LQRGVFDATG TVEHARAAQR
ALDEAAAAVR DEIAAFATRT PLSPTNASAA GAAPPQAENL VSVVTEPDPA VVAAHQDRLE
RIRELAAEVP AQWQSTKALS ALRAGDALGP SSPDGYLFTE GHLFVLTDDL RDNGDEVVVT
GRVLHHGTYA EPSTRTIAKN GGDPVQQVIL LPRFAPPPPE LITAAAPPGA TEPGQAVLPA
PAARAEQHPP AAPATAPARP ADDTPIEELD DPPSTSTWFS DLFSRSLPKQ DRQQALEALD
ALAEEALAHP GLRRAAAELG FHDFRIRIFP FWLTEQIRTS PAVPEAFRRE YLTATGMQTM
LYGRLASYVH GRWQRMPAPA SPVSAPIPIS DAYTDRIMQG LRDEYAYGHD PVFHDDGRVH
VYVSLQGDTL PLDVAAERHA PKLGIRSRPL TDADLATVVG HLGYRWLARA LRAAEDPGLT
GELFPWGSRR KRGPDETDPG ALEDIHADKG GLEIQIETPA GTRRGRRGWS KLLPWLRERV
PGGQRRILLA ADAALDGYRT HREHFALTGQ EALRDQAITE LTGLADAVRA AVRQAATAPA
VPARSRPQMA TLFDDDSSHH DDVDVEAVLA RITALSAVLP GARTTSARLS QLRPGDVVHR
SENSSAPLLV TQEPAEADGR WSVTGVVLTA GVRGETLSWP PPGRSPEPDP DVIVLHLPGS
LDGIVTPPPA AGPAHAEPPA TASPSPTAPP SAAPRSSRAT DPASPHQPAA PADSSISESG
PGPDAPWQER RAYAETLVEQ LRTLTLPEEL FTPADTTRIR QAALALAQAI GHRQTWECYR
HWIALQHVLA GVDLSAESGS SPRRLQERDR LLTLAREVVP AQDRAYGNED ISPRASFPAD
RPGSDVVVAT LENVIQQACA DLPLRAAAAA THEDDFAERI VPLWLNRLVR TAEQPLPAEF
RVAYFSNRQQ RIHRWIAVAV HAIVAVDGIS PTGHAEPVVP FGPSTEAERF QDRVMAGLRD
AQIRYEIHYW DSGLTAVWVQ SPDTRRQGGR LSLEVAAARF APHLGITPEP LLHSDIVEAL
EVYGTGWWAR FIAAMDDPAQ LGAVLARPSG RGGIMTTRQG LEIEVHTLQG TRYGVVPWQQ
ISDRWIRPAL SPVQRQILIE ADAAISHLQD DQLAIDDLGV RDQATAFRNE LTAVSREVLA
AFVDFAGRTP LGAASASRTA APQAALFDDP ALVAASFDKP STPQEEATLQ RVRELAAQLP
PQWHDSKPLS ALATGDALVR DEGGGVFVLT APPRDAETHV ELTGRVLERG IYADPSTLVI
SKDGGDTEQH VIGLPGFVPP PPEITGATAD ASDPSAPAGP PTSASETNTR SAPAARTTTA
APSSPAEDSA PAELTDIDIF YAFKLYGPRF MSIVLRSKDD PQVLRDEIST QRGTSGRRSG
GPEHGVSESI DVRRNGLEIE VGRGTRRGLV SWRRLRQWLT SNLDPLTQET FLAAEQLATG
YRTASTGFAA IGERHLHRQA VQEINDVLEM LTTDILERAL QADPPSRPPG RRAATAAAPD
GLFDLGAEAV TPTTDHPYAA HLARLRQLRA LWPAHWGEHI PLSQIQPGSV IHRPHSAELL
RVTEPVTDRG DDLELVGELV DSGARATATW PKHPFGSPVP NPDPTVEVIG LPQSLAPLFA
SGPQSAPASV PAETQSLRSA GHPAPAAEHP RDQQERPAFS PGSSRAMVPP SAAEAGPGAP
TPALPVVVPR PGTAPDAPAT ADADHTRDTP EERKARLSSA VDDLWAITLP KATFTPADAA
RIQQAIADLA ETLPGPRPVE IYRCWAVLQH VLATAEVPAE APAAARFHDA CEHLLDVART
ALSARANYYY DGTMIIVESL LKADHPPLEA ITTAVHAVTA LALADMPLRA SAATLEFDDF
TERVFSAWLA RLMHAGQVEL PPEFRAFYFS DRQSDLHQLL AAAVRGIVAV DGIDPTGAAA
PVEPAQPATE TERVQDEILT ALRATGVVYR MTYWPDGRTS IKMTHNGNES EHADLPLDIA
AARFAPQLGI TPKPLRDDDV VTGLSRYNTS WWAHFVSVMD DPAGLQELTS RINGQGNAHT
TAQGLHMEVH AVDGTRRGVA PWRQIIDRWI RPGLTHQQRR ILIEAMAAHH HSMQGHEVFA
ITGTDEHASA LRRELNTYAT MIRDEAMAFA ARTPLGPIGS PASARTSAPQ AEDLFSAAAS
DDDQTLSAAR QEVLDRISEL MAELPERWET TTALSHLRAG DALGRLRQDM RLFVLTEDPR
DTGDEVVLTG RVLRRGVYAD PTILTIAKDG GDPAQQTVRL PRFAPLPPEL TSDQGSVTED
LAHEQPAMTV AAPDSASAED AGDTRALTDV DIFYAVRRQS HWFLAALIRS IDDRKALDHA
ISGQGGSIGT RVGGPEPGLH QRIDLLRKGM EITVRAPDGT RYGVVSWGRL RQWIAPGLSP
GVGEAFLTAD RLETRYRAAG NGFAALGEHD LHRRAAREIE KILDELAATI VERALHAHQT
GSSTPAPDPR RPVASADSAS TLFGLDEAAS SATAAGDVYA AFLQRLHQLE SVLPPRWHVP
TPLSQLQPGS LLEHPGYSFD VFRTTGPAVD HGEYVEVAGE LIASGEPVTE RWYKHGSPDP
AVKVLALPRS LSPLFPSAPD SAPTVVASGA PAASPADRLT ASPALAAVPA DTALEGRSDD
LAASSPVVDV PASAPADPAG QPAVPDLIAE QAEAAEPVLP PADATGFSRE NLEIDDFIEV
DGVWHRVRRL NALSVTADNQ AGASPRHKYD HIGRVRRSHP DATSPTGPRW MRQAFALPID
AVRHARRHSD DQHLVYRVYR RDNVFVADTE PTDRPHYAID QGVWARVVNG TAEPVSGPPD
WKALTELADS AAAAPVPPAP ADPAADQDAA VLTSAAAAEG TAADRAASSG ADDLAVPEQV
RSAEGTAESA SSPAPPEAVS PAADLDDVPA QPGPLARRLV IGDTATPPTV SGTDFKRDPP
ALRQALKDNH FWWRKERRAW VYEGSSGDSD RHLAELRAAI AKLDRQHARN VEAAKAKAEA
AKTKPSYPPT AQQQAIIDAC VQGLNAVVPA LAGTGKTSTL RLVAHAMAEA NPTKKIVYFA
FNRSIADEAQ GVFPDNVTAN TAHSFARAGL IDGIYKKKIK NVGKGVRLPA EQAALLGIPA
ISIADGQEVT GEEAARLTMA TVRRYRESGD EQLSARHLPP DLPPTSQLAA AVLEYAHAAW
ADITNPAGKL LFDHDDYFKL WALGQPLLPY DMIFFDEAQD INGVLMKVIK AQPVQTIVVG
DSNQSIYGFR GAIDALEGWP ADVTLPLTQS WRFGPAVAAA GNRFLTLLGS PFLLEGNPAL
DTRIGEVPEP DAVLCRTNAG AIAIVVESLE AGKRVAMVGG GEALKDIARA ARDLKRGRRT
KHPELAGFPT WDAVREHVRN DDDNQSLKVF VNLVERYGAE SLIRTLDRLV DENVADEELA
AQLVVSTAHK AKGREWDHVK IANDFRVPNF SQDNGPIVMP SAEELRLAYV TVTRARHSVD
LGSLGWILND ELVAEVRAML PAGRSVERPM PAVAQAAQQQ APAADEPAQV HGAPPVTADS
PQHRARVAPA EAPVAADRSE PSRPGLDEHA GVSAAPLMSS PAPRADHTGS TAPQPADAEV
VLAPAGPLTL EQLRAYWREH QAAIMAGVSA DTRDSATAEL QRLADDPTLT VSASGNLYWF
KEGRSWQIGA VGSALSLLRS DMTVRAKEVA HLAVQLEKQL KDTGGQPVPW RAVNLRAIAA
TWRSGDGLNL RDALTVIRAD FDRSRGRTAT AAIKAHDRAI AAQQARAEHA QRQAALREHA
AATGRLLATV TELITGDEVE FTTVLDNGDV KRLGGDDRPG RANQVTITGT LRRQPDLKAK
VVEFVAGTGR WQHADGRHGP LVESRRGERW AYPSAEVLVR RAAHLQQLTV GPQAAHACVQ
QAEALEVSPA GVAAVRAYLT GLEQEPVLWS SRAARDTAAE HMSRSDADLD AVTTAIRAWF
DVAEAHDRLG DPAQEGGTLG YLALQLLAVH AERTRRGLEL APTQHHRDGW RTVTAWIGTQ
RWPDDLQGLA PQEYAGARDY THGRIHALGN FLNRTAAMDA ELQQWHDLGG VFTAVDRANE
QERARQQHRQ QADEQARALP ARIAALADPT GDQRAAGRRM TELLVSIAAE DVGEVPDSWA
VVSDYLSDAD RRGVDGADAL LDEVAALLEA EGYEAPSPYL RQQRAAWAAM SDAELLQAYA
AVPLDQADVY EGIERVLHER GWDADRGLPH RGTAHLLAEA QHPSEALVGR RVAYNDHDIQ
VLGLLTREAD GDFTITDSSG RHSLIHLDND EFVGVVAPDD PRLADLEPQE LLTPELEARL
VGVERHLRHL WDGHRRLDDP EFITAYQQQR YLAAIWQERP DHAAVDAAVP GHALPVEELP
GLAAEISSIS GLPALALPES EAFGQGEFSH ASPQTPPTAP TADERGIDAS VTGRERPAGE
PVSDELLAEL ASESDPSDLP VSAVAAETAA APAAATTVTD AEARTVPASA VPPSREPHIG
DNEDHQFIGA VTGLEGATQD EAAQSLRAES PGALPAIPAG GLSPLEGSGG VLQRPGPADR
AGDRPGMAEP DGRSAQQPDR LSGPAGLAEH DPERSRAGGL GPDAAAADRY LADPQLTPFR
WVPGQPLSPS DPAARLAANM AAVEVWHLLS RQERRATPSE QQILARFSGW GSLSKVFDDE
HQPMAAERAR LQQLLTAEEY AAARASTLTA YYTDPAYAAI AWQALADLGF DGGVVLEPGC
GPGVFLLSAP EGAHKVGVEI DPFTARVAAE LNPDATIHAA SLAKLHFDEE TFDLVIGNLP
FDKVKLPDPR YNARLSLSIH EHFAVKSVAE TRPGGLVAVF VSRFLMDGQN PQARRELAAM
ADLAAAIRLP SGAHAKVAGT NAVTDFLIFR RREHSRPPAG IPFERTRVFA EQNGERFRVN
EAFYDDPARV LGQMRLGHGA RGRLALTVDG NPDAAEALHA EVNRQVDQAR QDGLTMSERP
AHLRGASLLP QPTLASAPQM EQGTITAHPD GTFTRLVGTQ QVVYAPKAGH ADELRQLLAL
RDLQLELAAE ETATRDDTPR VHHLRGELNR LYDQYVSSYG AITRFTWART GRVNPETGEP
IMRRNRPDLG GFRKDPHAAQ VLALELDYDP PTRRAIKSDI FTQRTRYVLP PRLGADTAAD
ALQICLHDHG EIRLGEIARL LGVEHDIEAR EALGTLVFDD PETGRLVIAS EYLSGDVRRK
LEQAQRACEK DPRLQVNVDA LAKVQPRDLG PAEIIAQMGA DWIPASVIQD FLRDILDDPA
IVVANPYPGV WSVENGNRTS VLATSRWGTA QANALTLTKH ILVGTHLAFT VGDSEQTTAA
RNKAREIEEH FGRWVWQDPD RADELCRRYN HTHNARVPRS FDDYVIEPVG MSPALRLRDS
QHAGIARLLY QPDVGIIHDT GAGKTLTAVV ALEERKRLGM SAKPCMVVQK TKLDDFRAEY
LRAYPDARLL VADTEDLKTA EKRQEFLARC QTTTNVTVIL SREAFQAIPV SPQRQEQFLR
ASMREWHHAV ESARKAGCSK DTIKELERAR TSAENRIARK LEGIKHDITL DWEKTGIDFI
VYDEAQALRL GQIISRIPGL AQEGSDRAVD ARLKVQVNRE RFGSGRIGLF SATPFANGAG
EIWSYLDLLG ANPGHFDSWL RTHCRVELVY EYSATGDFKQ KARLIEIVNA VELHLALREV
SDIKLGSALQ RELPEIRGGK PQILTVPATP EHLEHATELR RLLAEAESDS SQASAIHLRI
QGEAAKAALD VRLVGKTPSA PQKIDVLAEQ VYQRWLRHRG DVYPAADGTP HPVTGSLQFI
FCGLSTPKRR RKDEGEWNFY REITRILVSK GIPRPQIAFV HDATDPDKMA QLTHRANNGE
VQVLIGSPQK GAEGLNVHRR AIASYHVTPD WNYGTFHQEL SRVVREGNLN NVVDVIVLVH
SPSLDALRHE RQRQKQMTHA PLLTGEIEGR VIRVPQDDVT AAEAVAAASG DPRLLAKMKL
EIRIKGLRAE ANQWDQDKAS LAYRIRRTQT ALEENEGTRA QLEHALQQRR ATRGANFAIT
LNGRHFTKRP EAADHLTALI SRQAASAPRT ETTATPLGEL GGFDLTATYI PITLPAEDGT
WHYADHSISV TLNGLPRHEP VLLRASDLPP GQSILSRLEN AIADLDRRLS TIDQRITFLH
EEISRAQATS DDPFPRQQEL DDLVVELTTL EAELAAEAAE LSERDKALIE AGEELADTDT
ANLSDSAFWQ DTYAKVQGLP DAKSFTDWYT ATYSAMPEER QPLVMQAYQD IWPQHSPEAA
AHTSGRAPGR GDGTGSGGGW AKSTGPASRT LPHPVNDGSA QTSSAAAAAT VTALPAEVLA
GLRARFVAIS LATKRVAQWA HANHEDNFTF VYGKWLTDQA IDYAWDRRES DPLLIDELTR
PALMDQLIAD LAPQIYRAHR AGVHAQPTTP SPPWLVYQIT YRTDGAPIQG LPGAEWFKTL
HEVIAARQGR VRVLDDGRIE LLWLVQGFDG DRDDYVAAPM DPQDAWRWMT HHPDALISFS
NASSSAFEAG RQQHLVDKAC AYAVQHEELR TLAPEALFPA WMTWQASVGY PDVPKDFLDR
RSNDEVFRES FDHLASLQIH QALTHGPMPI PRLTLHASFV AACADATDRA AERDRRHYVW
RVGDDYVTAD FPPAADHVSV AHPDGWAQHL DGVTVALPEA PTAEPANPGK RSGWPSFAGL
SGYLQPYRQT DDIAADQQHL AQAYVLYTAA RNAADWSEHP AAAQRDQLCL TISRHFNALS
PFPSDRDQAA EHLAQLDQAT AQLGDMVEGD LRTAAYLLML AAERYGARLM PRDNSADVPL
EVPRELNLDT AQAALNVEPF ATRTAHQHYR AALLDRIRVW APLREHYPRL QGPRQRLHTA
LFRQKEQDQR EVSFTLTHWR QVVDDALLAA RECQDPKERV ALASIAREAL AYHQRLGAHV
RAAERRATPY TDHTAAQAGV DRLDAAWQAW LATATGSMLH KRRSSSRPPA NLKQAILAQV
MAGKALERTR DDDSDAARSW GFAHAVHDVA LALAAEEFHS PHDLEVLNDL IAVAHTHPAR
LVLSDLSVKP DPPSSSRSAA SASVDLSDPA AALNAAIGAH DRRPYTSAEE ISQAVERLYQ
AFGEGQPQRS EVSSHMERIW EQLDRLRSAD VLHQGITQAS FDWHELAASA KRAHEGASVA
EKASLTQLAA DATQHADRLG AHLHWTSHYS HPYTSAEEIL EEDRRLWLTY RAWSTSATVR
GGNHGLVELF SRQRHRALIG RVDDRKGTAA VWKRIVALAD ASFALTLQLP ARAYADEGDQ
QLLQRLTAHA YHHAGRLDKL LEQPDHLSAS LTAAIAAIPD YPNLLERDEL AAEADREHHE
AKALPWHTLS AVLAESVYRI YTPGKAHAKK DPEHAARVFD RLYDAVIDGG ITLVTLAENG
DINITSAASY LTRPISPLPS ADARQWLATH PSPAPQELRH PGMVALCKQV VEHAYNDVRL
RHYIQENAHL PLTELNPLRR WLNDQSLLDH RDVPEPFRAR LTADEQFHRV ICQLAGVHIY
LACTATQELD PSDRIEHDRA QVQLSETIAG AVAESDTLPL AIDDDSASVE TAANAERHQR
ATTVDSALTE FDAAQQAPAD LGTVVEAETP AHDENRAAVE DNNAKGEGTS THVDGRVVPG
VRWGHAWEDN GRRSKVNFPT PEEAQAALER FRAYAADPPA RGTARLDNSA NGDGPLRARD
VIDLPSWDIY GGRVEAIRDG GITNPRAKQP TSMTEIEVRR ADGTRVHARV PTGATVLRYL
PDDARAHRDA LLEPILQRER AEMEATRAAI RAEQQARQEL KAWDGTSEIT EGNLRYGAAR
IGLPPAMADE AVAGNERVPG RVYTNAATFN QHLESEGPES FQQGVMAAHA LVDTAPLHQE
GAIGWSLATV LAALGRASAD RDLDAEYLAG RDLARRLMDN DEQALNGAST RTREGAADYL
THHGRALTNV QGPEGEAART RVEQARHRLE AHTPEPTAGA ENELAPVPGV FSPEAGQRIA
DAAAAYRQAL AGDDEMAMLD AWVAFRDLID EEGRGHGLDS PQALERDRLH EAGVDLRDAW
DRAHAEQIRA TRRRLQQRVD TSAEAVKLAD AGDLDGALAL IDQAEAEIGG EGWESLRTQA
REAWIDPTPL PSTDDGTPPS PPGMSAAQRA RLVEAIEEHA AGYAWTSDPG RYIAETHGEH
RSNGEAGQVE KDWIDAYIAA HPEVRAFSNT ERVRRKRQRE ARQETQRQAD RQRSRELSSQ
SYEAFHAGDY DRALALIDEA EQISPASERW AAIREQINAA RPAAPGPVGA ENSLDVEPDA
QGAQSQHRGD VAHADASALE SANAPTEPAP EIPPAEALSG SSPHATPSRG GAEQAPSVEA
LAQELSDYES IHLLDARPGD VLRILDRYGK WGAPIVYART AHRKNGIQLI GTHPSTGASR
TLTLRVARDA RNLQRRLDAH RLQELIDQAA AEGAIPATGA TVQPGDLITY RMRVEAHFRD
FLHGDDPPLE GSTITVRGTV ADVREESDHW VVDLHPGTAT WEGEDGGRGT TSVFDATTLT
QQNIVYRIPP PAAAAPSADQ LTTAQHIVDA DHRDIGHLGS VDADMTQAEQ ERHQTTAGMR
QPAAITRPAA AAHLSGPTNE PPPSAFTSGT EHEADPTTHH HEVQLLASLF LDPAQIAEVR
QVLDGPEDFT DPELGRLYAA VLRLHDRGEP IDARRIDIEA GTARSSVTHN VDQLKTAMHA
ITSGQQPVAA LPHALRLAEL AAARLSAEYA AALAAPTRVY QWEGPVPVAL AHAADRARDN
GRPYYVYGDE GHTDARVSDT PPADTGYWMV TASGLWVSLS GTTIATISIA DSDFDASRGR
PAVVVTDVHA DLEHKLAAEK PFLLAACISP VAAMVMATRT AENQQRPCLV YMRQNMFVVT
DAVPPDVHAY FSVTADGSWL QHRGGEQQPA EAPKTAAAFT ALTTLAPAPP CAAAAANPAA
PAATSGTAYQ PPTADPPAAP GIGMGL
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